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Journal of Neuroscience, Vol 13, 3155-3172, Copyright © 1993 by Society for Neuroscience
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
A Bulfone, L Puelles, MH Porteus, MA Frohman, GR Martin and JL Rubenstein
Department of Psychiatry, University of California, San Francisco 94143- 0984.
The expression patterns of four genes that are potential regulators of
development were examined in the CNS of the embryonic day 12.5 mouse
embryo. Three of the genes, Dlx-1, Dlx-2 (Tes-1), and Gbx-2, encode
homeodomain-containing proteins, and one gene, Wnt-3, encodes a putative
secreted differentiation factor. These genes are expressed in spatially
restricted transverse and longitudinal domains in the embryonic neural
tube, and are also differentially expressed within the wall of the neural
tube. Dlx-1 and Dlx-2 are expressed in two separate regions of the
forebrain in an identical pattern. The Gbx-2 gene is expressed in four
domains, two of which share sharp boundaries with the domains of the Dlx
genes. One boundary is in the basal telecephalon between deep and
superficial strata of the medial ganglionic eminence; the other boundary is
in the diencephalon at the zona limitans intrathalamica. The Wnt-3 gene is
expressed in a dorsal longitudinal zone extending from the hindbrain into
the diencephalon, where its expression terminates at the zona limitans
intrathalamica. Reciprocal patterns of expression are found within the
dorsal thalamus for the Gbx- 2 and Wnt-3 genes. These findings are
consistent with neuromeric theories of forebrain development, and based
upon them we suggest a model for forebrain segmentation.
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A. A. Lavdas, M. Grigoriou, V. Pachnis, and J. G. Parnavelas
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J. L.R. Rubenstein, S. Anderson, L. Shi, E. Miyashita-Lin, A. Bulfone, and R. Hevner
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Y. Hatanaka and E. G. Jones
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Cereb Cortex,
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E. M. Miyashita-Lin, R. Hevner, K. M. Wassarman, S. Martinez, and J. L. Rubenstein
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R. Meech, P. Kallunki, G. M. Edelman, and F. S. Jones
A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins
PNAS,
March 2, 1999;
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S. Retaux, M. Rogard, I. Bach, V. Failli, and M.-J. Besson
Lhx9: A Novel LIM-Homeodomain Gene Expressed in the Developing Forebrain
J. Neurosci.,
January 15, 1999;
19(2):
783 - 793.
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S Garel, F Marin, R Grosschedl, and P Charnay
Ebf1 controls early cell differentiation in the embryonic striatum
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January 12, 1999;
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