Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

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Journal of Neuroscience, Vol 13, 3155-3172, Copyright © 1993 by Society for Neuroscience

ARTICLE

Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

A Bulfone, L Puelles, MH Porteus, MA Frohman, GR Martin and JL Rubenstein
Department of Psychiatry, University of California, San Francisco 94143- 0984.
The expression patterns of four genes that are potential regulators of development were examined in the CNS of the embryonic day 12.5 mouse embryo. Three of the genes, Dlx-1, Dlx-2 (Tes-1), and Gbx-2, encode homeodomain-containing proteins, and one gene, Wnt-3, encodes a putative secreted differentiation factor. These genes are expressed in spatially restricted transverse and longitudinal domains in the embryonic neural tube, and are also differentially expressed within the wall of the neural tube. Dlx-1 and Dlx-2 are expressed in two separate regions of the forebrain in an identical pattern. The Gbx-2 gene is expressed in four domains, two of which share sharp boundaries with the domains of the Dlx genes. One boundary is in the basal telecephalon between deep and superficial strata of the medial ganglionic eminence; the other boundary is in the diencephalon at the zona limitans intrathalamica. The Wnt-3 gene is expressed in a dorsal longitudinal zone extending from the hindbrain into the diencephalon, where its expression terminates at the zona limitans intrathalamica. Reciprocal patterns of expression are found within the dorsal thalamus for the Gbx- 2 and Wnt-3 genes. These findings are consistent with neuromeric theories of forebrain development, and based upon them we suggest a model for forebrain segmentation.

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K. Wassarman, M Lewandoski, K Campbell, A. Joyner, J. Rubenstein, S Martinez, and G. Martin
Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
Development, January 8, 1997; 124(15): 2923 - 2934.
[Abstract] [PDF]

G. Mastick, N. Davis, G. Andrew, and S. Easter
Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain
Development, January 5, 1997; 124(10): 1985 - 1997.
[Abstract] [PDF]

N Warren and D. Price
Roles of Pax-6 in murine diencephalic development
Development, January 4, 1997; 124(8): 1573 - 1582.
[Abstract] [PDF]

M Yoshida, Y Suda, I Matsuo, N Miyamoto, N Takeda, S Kuratani, and S Aizawa
Emx1 and Emx2 functions in development of dorsal telencephalon
Development, January 1, 1997; 124(1): 101 - 111.
[Abstract] [PDF]

K. Nicholson-Flynn, S. E. Hitchcock-DeGregori, and P. Levitt
Restricted Expression of the Actin-Regulatory Protein, Tropomyosin, Defines Distinct Boundaries, Evaginating Neuroepithelium, and Choroid Plexus Forerunners during Early CNS Development
J. Neurosci., November 1, 1996; 16(21): 6853 - 6863.
[Abstract] [Full Text] [PDF]

J. A. De Carlos, L. Lopez-Mascaraque, and F. Valverde
Dynamics of Cell Migration from the Lateral Ganglionic Eminence in the Rat
J. Neurosci., October 1, 1996; 16(19): 6146 - 6156.
[Abstract] [Full Text] [PDF]

C. Metin and P. Godement
The Ganglionic Eminence May Be an Intermediate Target for Corticofugal and Thalamocortical Axons
J. Neurosci., May 15, 1996; 16(10): 3219 - 3235.
[Abstract] [Full Text] [PDF]

S Millet, E Bloch-Gallego, A Simeone, and R. Alvarado-Mallart
The caudal limit of Otx2 gene expression as a marker of the midbrain/hindbrain boundary: a study using in situ hybridisation and chick/quail homotopic grafts
Development, January 12, 1996; 122(12): 3785 - 3797.
[Abstract] [PDF]

A Stoykova, R Fritsch, C Walther, and P Gruss
Forebrain patterning defects in Small eye mutant mice
Development, January 11, 1996; 122(11): 3453 - 3465.
[Abstract] [PDF]

N. Holland, G Panganiban, E. Henyey, and L. Holland
Sequence and developmental expression of AmphiDll, an amphioxus Distal-less gene transcribed in the ectoderm, epidermis and nervous system: insights into evolution of craniate forebrain and neural crest
Development, January 9, 1996; 122(9): 2911 - 2920.
[Abstract] [PDF]

Y Nakagawa, T Kaneko, T Ogura, T Suzuki, M Torii, K Kaibuchi, K Arai, S Nakamura, and M Nakafuku
Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells
Development, January 8, 1996; 122(8): 2449 - 2464.
[Abstract] [PDF]

R. Hardy and V. Friedrich
Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted foci
Development, January 7, 1996; 122(7): 2059 - 2069.
[Abstract] [PDF]

M D Schonemann, A K Ryan, R J McEvilly, S M O'Connell, C A Arias, K A Kalla, P Li, P E Sawchenko, and M G Rosenfeld
Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.
Genes & Dev., December 15, 1995; 9(24): 3122 - 3135.
[Abstract] [PDF]

M Qiu, A Bulfone, S Martinez, J J Meneses, K Shimamura, R A Pedersen, and J L Rubenstein
Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.
Genes & Dev., October 15, 1995; 9(20): 2523 - 2538.
[Abstract] [PDF]

K Shimamura, D. Hartigan, S Martinez, L Puelles, and J. Rubenstein
Longitudinal organization of the anterior neural plate and neural tube
Development, January 12, 1995; 121(12): 3923 - 3933.
[Abstract] [PDF]

S Tajbakhsh and M. Buckingham
Lineage restriction of the myogenic conversion factor myf-5 in the brain
Development, January 12, 1995; 121(12): 4077 - 4083.
[Abstract] [PDF]

G Fishell
Striatal precursors adopt cortical identities in response to local cues
Development, January 3, 1995; 121(3): 803 - 812.
[Abstract] [PDF]