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Journal of Neuroscience, Vol 13, 3827-3838, Copyright © 1993 by Society for Neuroscience
A role for postsynaptic neurons in determining presynaptic release properties in the cricket CNS: evidence for retrograde control of facilitation
GW Davis and RK Murphey
Neuroscience and Behavior Program, University of Massachusetts, Amherst 01003.
Intracellular recording sin the cricket cercal system show that the
synaptic terminals of a single sensory neuron can facilitate at one target,
the medial giant interneuron (MGI), and simultaneously depress at another
target, interneuron 10-3. A quantal analysis of transmission at these
synapses demonstrates that facilitation and depression are properties of
the presynaptic cell. For facilitating synapses contacting MGI, the mean
quantal content (m), determined from the probability of the failures,
increases for the second EPSP, while the quantal size (q) remains constant.
Similarly, an analysis of depression for those synapses contacting 10-3
supports a presynaptic mechanism for depression. Since facilitation and
depression are presynaptic and their expression at the synapses of a
single, identified sensory neuron are correlated with the target
interneuron, we conclude that these properties are regulated locally, at
the synapse, possibly by an interaction with the postsynaptic cell.
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