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Journal of Neuroscience, Vol 14, 14-28, Copyright © 1994 by Society for Neuroscience
Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system
F Lamballe, RJ Smeyne and M Barbacid
Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543.
The mammalian trkC gene encodes a tyrosine protein kinase that serves as a
functional receptor for neurotrophin-3 (NT-3). Here, we report that trkC is
widely expressed in the developing and adult nervous system. Using in situ
hybridization, we first detect trkC transcripts in the telencephalon and
spinal cord of embryonic day 9.5 mouse embryos. In later embryonic
development, trkC is expressed in various structures of the CNS including
the caudatoputamen, septal nuclei, cerebellum, and brainstem. In the PNS,
trkC hybridization appears to correlate, both temporally and spatially,
with the outgrowth of axons toward their peripheral targets. trkC
transcripts were also identified in the autonomous enteric nervous system
as well as in some non-neural tissues such as the wall of the aorta and the
acini of the submaxillary and sublingual glands. In the adult mouse, trkC
gene expression is heterogeneously distributed throughout the brain, with
highest levels in limbic and diencephalic structures. These results
indicate that the trkC gene is widely expressed in the three identified
branches of the mammalian nervous system and appears to correlate with the
expression of NT-3, its cognate ligand. The apparent colocalization of trkC
transcripts with NT-3 raises the possibility this neurotrophin exerts its
trophic effects by a paracrine and/or autocrine mechanism.
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