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Journal of Neuroscience, Vol 14, 442-450, Copyright © 1994 by Society for Neuroscience
Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study
PA Garris and RM Wightman
Department of Chemistry, University of North Carolina at Chapel Hill 27599-3290.
The regulation of extracellular dopamine (DA) concentrations was examined
and compared in vivo in four projection fields of mesotelencephalic
dopaminergic neurons with fast-scan cyclic voltammetry at carbon-fiber
microelectrodes. Transient electrical stimulation of ascending DA fibers in
a near physiological range of frequencies (10-20 Hz) elicited similar
levels of extracellular DA in the medial prefrontal cortex (MPFC), basal
lateral amygdaloid nucleus (BAN), caudate-putamen (CP), and nucleus
accumbens (NAc) despite the documented 90-fold disparity in DA tissue
levels and terminal density. However, marked differences were observed in
the dynamics and overall frequency dependence of the evoked synaptic
overflow of DA. These differences are due to the significantly different
rates of release and uptake found in each of the four regions. For example,
rate constants for the release of the four regions. For example, rate
constants for the release and uptake of DA were similar in the MPFC and BAN
but approximately 8 and 50 times less, respectively, than that in the CP
and NAc. When the parameters were normalized to endogenous DA tissue
content, a unique picture emerged: compared to all other regions, relative
release was 10-fold greater in the MPFC while relative uptake was at least
10 times less in the BAN. The results further differentiate the functional
characteristics of mesotelencephalic dopaminergic systems and demonstrate
the regiospecific nature of DA neural transmission in the brain. In
addition, the regulation of extracellular DA levels in the MPFC and BAN is
suitable for the "long- range" transfer of chemical information in the
brain and is consistent with a hypothesis of extrasynaptic
neurotransmission.
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