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Next Article 
Journal of Neuroscience, Vol 14, 459-471, Copyright © 1994 by Society for Neuroscience
Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons
F Sohrabji, RC Miranda and CD Toran-Allerand
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032.
We have previously shown that neurons in the basal forebrain colocalize the
neurotrophin receptor p75NGFR and estrogen receptors. The present study was
designed to examine (1) if neural neurotrophin targets respond to estrogen
as a general phenotypic feature and (2) if NGF receptor mRNAs are regulated
by estrogen, using a prototypical target of NGF, the dorsal root ganglion
(DRG) (sensory) neuron. We demonstrate, for the first time, the presence of
estrogen receptor mRNA and protein (binding sites) in adult female rat DRG.
Moreover, estrogen receptor mRNA expression, while present in DRG neurons
from both the ovariectomized (OVX; estrogen deficient) and intact female
rat, was downregulated, as in the adult CNS, during proestrus (high
estrogen levels) and in OVX animals replaced with proestrus levels of
estrogen, as compared to OVX controls. In contrast, although the mRNAs for
the NGF receptors p75NGFR and trkA were also expressed in DRG neurons from
OVX and intact animals, expression of both NGF receptor mRNAs was
upregulated in sensory neurons during proestrus, as compared to the OVX
condition. Estrogen replacement, on the other hand, resulted in a transient
downregulation of p75NGFR mRNA and a time-dependent upregulation of trkA
mRNA. Estrogen regulation of NGF receptor mRNA in adult peripheral neural
targets of the neurotrophins supports the hypothesis that estrogen may
regulate neuronal sensitivity to neurotrophins such as NGF and may be an
important mediator of neurotrophin actions in normal neural function and
following neural trauma.
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