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Journal of Neuroscience, Vol 14, 472-485, Copyright © 1994 by Society for Neuroscience
Regulation of the POU domain gene SCIP during cerebral cortical development
GD Frantz, AP Bohner, RM Akers and SK McConnell
Department of Biological Sciences, Stanford University, California 94305.
The mammalian cerebral cortex is patterned into layers of neurons that
share characteristic morphologies, physiological properties, and axonal
connections. Neurons in the various layers are thought to acquire their
lamina-specific identities shortly before the time of their final mitosis
in the cortical ventricular zone. In order to investigate the molecular
basis of laminar patterning in the CNS, we have performed in situ
hybridization studies of the POU homeodomain gene SCIP (also known as Tst-1
or Oct-6), which is expressed in proliferating Schwann cells in the PNS and
O2A progenitor cells in the developing CNS. In the CNS of adult rats, SCIP
is expressed at high levels in the cerebral cortex, specifically in layer 5
pyramidal neurons that form subcortical axonal connections. SCIP is both
temporally and spatially regulated during cortical development. Its initial
expression in the intermediate zone and cortical plate is correlated with
the early migration and differentiation of layer 5 neurons. SCIP
hybridization was not, however, observed within the ventricular zone during
the period of neurogenesis. SCIP is also expressed at high levels in the
neurons of cortical layer 2/3, during their migration and differentiation
within the cortical plate. This expression in the upper layers is
apparently downregulated during postnatal periods, with the adult pattern
apparent by postnatal day 30 (P30). POU domain genes are thought to play a
role in cell lineage and cell fate decisions in several systems; thus, SCIP
may serve a function in generating discrete laminar phenotypes in the
developing cerebral cortex. In addition, since SCIP is a putative repressor
of myelin gene expression, our results suggest that SCIP plays a role in
regulating transcription in differentiated CNS neurons as well as in
proliferating glial precursors.
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