 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 14, 1106-1113, Copyright © 1994 by Society for Neuroscience
Opioid actions on rat anterior cingulate cortex neurons in vitro
E Tanaka and RA North
Vollum Institute, Oregon Health Sciences University, Portland 97201.
Intracellular recordings were made from layer V pyramidal neurons in slices
of rat anterior cingulate cortex, using electrodes that contained potassium
methylsulfate and biocytin. [Met5]enkephalin (300 nM to 30 microM)
reversibly reduced the amplitude of EPSPs evoked by stimulation of the
subcortical white matter; the half-maximal concentration was about 800 nM.
These EPSPs were blocked by (+/-)-2- amino-5-phosphonovaleric acid and
6-cyano-7-nitroquinoxaline-2,3-dione. [Met5]enkephalin also reduced the
amplitude of bicuculline-sensitive IPSPs evoked by stimulation within layer
V; the half-maximal concentration was about 60 nM. Both these actions of
[Met5]enkephalin were mimicked by the delta-selective agonist DPDPE
(Tyr-D-Pen-Gly-Phe-D- Pen) but not by the mu-selective agonist DAMGO
(Tyr-D-Ala-Gly-MePhe-Gly- ol); they were blocked by the delta-selective
antagonist naltrindole (apparent dissociation constant of about 0.3 nM) but
not by the mu- selective antagonist CTOP
(D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2). [Met5]enkephalin did not change
the amplitudes of depolarizations evoked by direct application of glutamate
or hyperpolarizations evoked by direct application of muscimol (at -55 mV).
Fifty percent (22 of 45) of pyramidal cells were hyperpolarized by
[Met5]enkephalin; this resulted from an increase in potassium conductance,
and it was mimicked by DPDPE and blocked by naltrindole. Five of seven
nonpyramidal cells were hyperpolarized by [Met5]enkephalin; this was
mimicked by DAMGO and blocked by CTOP.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
|
|
 
D. Chao, A. Bazzy-Asaad, G. Balboni, S. Salvadori, and Y. Xia
Activation of DOR Attenuates Anoxic K+ Derangement via Inhibition of Na+ Entry in Mouse Cortex
Cereb Cortex,
September 1, 2008;
18(9):
2217 - 2227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. K. Lambe, R.-J. Liu, and G. K. Aghajanian
Schizophrenia, Hypocretin (Orexin), and the Thalamocortical Activating System
Schizophr Bull,
November 1, 2007;
33(6):
1284 - 1290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. W.F. Shum, L.-J. Wu, M.-G. Zhao, H. Toyoda, H. Xu, M. Ren, R. Pinaud, S. W. Ko, Y.-S. Lee, B.-K. Kaang, et al.
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
Learn. Mem.,
April 10, 2007;
14(4):
304 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-W. Yang, H.-C. Shih, and B.-C. Shyu
Intracortical Circuits in Rat Anterior Cingulate Cortex Are Activated by Nociceptive Inputs Mediated by Medial Thalamus
J Neurophysiol,
December 1, 2006;
96(6):
3409 - 3422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-J. Wu, M.-G. Zhao, H. Toyoda, S. W. Ko, and M. Zhuo
Kainate Receptor-Mediated Synaptic Transmission in the Adult Anterior Cingulate Cortex
J Neurophysiol,
September 1, 2005;
94(3):
1805 - 1813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Liauw, L.-J. Wu, and M. Zhuo
Calcium-Stimulated Adenylyl Cyclases Required for Long-Term Potentiation in the Anterior Cingulate Cortex
J Neurophysiol,
July 1, 2005;
94(1):
878 - 882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhang, G. T. Gibney, P. Zhao, and Y. Xia
Neuroprotective role of delta -opioid receptors in cortical neurons
Am J Physiol Cell Physiol,
June 1, 2002;
282(6):
C1225 - C1234.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Taylor and W. W. Fleming
Unifying Perspectives of the Mechanisms Underlying the Development of Tolerance and Physical Dependence to Opioids
J. Pharmacol. Exp. Ther.,
April 1, 2001;
297(1):
11 - 18.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev,
January 1, 2001;
81(1):
299 - 343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Wei, P. Li, and M. Zhuo
Loss of Synaptic Depression in Mammalian Anterior Cingulate Cortex after Amputation
J. Neurosci.,
November 1, 1999;
19(21):
9346 - 9354.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Svingos, C. L. Clarke, and V. M. Pickel
Cellular Sites for Activation of delta -Opioid Receptors in the Rat Nucleus Accumbens Shell: Relationship with Met5-Enkephalin
J. Neurosci.,
March 1, 1998;
18(5):
1923 - 1933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Martin, Z. Nie, and G. R. Siggins
µ-Opioid Receptors Modulate NMDA Receptor-Mediated Responses in Nucleus Accumbens Neurons
J. Neurosci.,
January 1, 1997;
17(1):
11 - 22.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
