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Journal of Neuroscience, Vol 14, 2020-2031, Copyright © 1994 by Society for Neuroscience
Cogeneration of neurons with a unique molecular phenotype in layers V and VI of widespread lateral neocortical areas in the rat
Y Arimatsu, I Nihonmatsu, K Hirata and K Takiguchi-Hayashi
Laboratory of Neuromorphology, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Monoclonal antibody PC3.1 detects a unique subpopulation of neurons located
mainly in layer VI and, to a lesser extent, in layer V within the lateral
neocortical areas in the rat. In an attempt to characterize these neurons,
we determined the time of their generation in selected neocortical areas by
a double-labeling experiment combining quantitative long-survival
3H-thymidine autoradiography and immunohistochemistry for the PC3.1
antigen. We found that the vast majority of PC3.1-positive neurons in both
layers V and VI were generated concurrently at embryonic day 15 in all
areas examined, demonstrating a strict correlation between the molecular
identity of neurons and the time of their generation, irrespective of their
final positions along the radial and tangential axes. In contrast, PC3.1-
negative neurons, which should represent more diverse phenotypic
identities, were generated during a more extended period of cortical
development and tended to exhibit radial (inside-to-outside) and tangential
(ventral-to-dorsal and rostral-to-caudal) neurogenetic gradients. Our
findings indicate that laminar and tangential locations of cortical neurons
are not established solely by a combination of mechanisms for the
inside-out movement of newly generated neurons in each cortical area and
for the broad tangential neurogenetic gradients. The results of this study
suggest a distinct way of cortical development in which neurons with a
common molecular phenotype are generated concurrently and migrate toward
their eventual positions, which are not necessarily located in a single
lamina. In addition, our results suggest some kind of tangential
heterogeneity in the mechanism involved in neocortical histogenesis,
supporting the concept of early regional specification within the
neocortex.
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