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Journal of Neuroscience, Vol 14, 3655-3671, Copyright © 1994 by Society for Neuroscience
Central sprouting and functional plasticity of regenerated primary afferents
HR Koerber, K Mirnics, PB Brown and LM Mendell
Department of Neurobiology, University of Pittsburgh, Pennsylvania 15261.
A combination of neuroanatomical and electrophysiological techniques was
used to study the effects of peripheral axotomy and regeneration of primary
afferents on their central projections in the spinal cord. Individual
regenerated afferent fibers were impaled with HRP-filled electrodes in the
dorsal columns of alpha-chloralose-anesthetized cats and activated by
current pulses delivered via the intracellular electrode. The resulting
cord dorsum potentials (CDPs) were recorded at four rostrocaudal locations
and HRP was iontophoretically injected into the fiber. Central
distributions of boutons and CDPs were compared with peripheral receptor
type to determine the accuracy of peripheral regeneration and the effects
of central-peripheral mismatches. Reconstruction of the central projections
of 13 individual afferents for which the adequate stimulus and CDPs had
been recorded revealed many abnormalities. For example, unlike controls,
four group I and II afferents with central projections typical of
proprioceptors (concentrated in laminae V, VI, and VII) innervating either
cutaneous or noncutaneous targets evoked measurable CDPs. Three other group
II or A beta afferents innervating low-threshold mechanoreceptors with
central terminations confined to the dorsal horn exhibited extensive
collateralization in laminae I and II in addition to large numbers of
terminals in laminae III-IV. These fibers activated central networks whose
adaptation behavior was identical to those evoked by high- threshold
mechanoreceptive afferents in controls. These results suggest that primary
afferents and their central connections are capable of significant
modifications following axotomy and regeneration. In addition, the
anatomical studies indicate some reorganization in the laminar distribution
of boutons as well as in bouton size.
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