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Journal of Neuroscience, Vol 14, 4756-4768, Copyright © 1994 by Society for Neuroscience
Tenascin demarcates the boundary between the myelinated and nonmyelinated part of retinal ganglion cell axons in the developing and adult mouse
U Bartsch, A Faissner, J Trotter, U Dorries, S Bartsch, H Mohajeri and M Schachner
Department of Neurobiology, Swiss Federal Institute of Technology, Zurich.
The molecular determinants controlling the topographically restricted
distribution of neural cells in the mammalian CNS are largely unknown. In
the mouse, myelin-forming oligodendrocytes are differentially distributed
along retinal ganglion cell axons. These axons are myelin free
intraretinally and in the most proximal (i.e., retinal) part of the optic
nerve, but become myelinated in the distal (i.e., chiasmal) part of the
optic nerve. Tenascin protein and mRNA are detectable in increased amounts
at the retinal end of the developing optic nerve before the arrival of
oligodendrocyte progenitor cells and are restricted to this region in the
adult optic nerve. Tenascin is a nonadhesive substrate for oligodendrocytes
and their progenitor cells in vitro when offered as a substrate in choice
with polyornithine. These observations suggest that tenascin is critical
for the establishment and maintenance of the restricted distribution of
myelin- forming oligodendrocytes along retinal ganglion cell axons of the
mouse.
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