 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 110-116, Copyright © 1995 by Society for Neuroscience
Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress
S Maccari, PV Piazza, M Kabbaj, A Barbazanges, H Simon and M Le Moal
Psychobiologie des Comportements Adaptatifs, INSERM U. 259, Universite de Bordeaux II, France.
The development of the organism is subjected to critical and complex
influences during the perinatal period. Prenatal and postnatal stresses can
have different long-term behavioral effects, and appropriate postnatal
manipulations can counteract the behavioral effects of prenatal stress. In
the present study, we investigated the involvement of changes in the
activity of the hypothalamo-pituitary-adrenal (HPA) axis in the long-term
effects of prenatal and postnatal events and of interactions between them.
We investigated stress-induced corticosterone secretion and hippocampal
corticosteroid receptors in male adult rats submitted to prenatal and/or
postnatal manipulations. Repeated restraint during the last week of
pregnancy was used as prenatal stressor, and adoption at birth was used to
change the postnatal environment. We found that (1) prenatal stress
prolongs stress-induced corticosterone secretion in adult rats, which was
attributed to the observed decrease in central corticosteroid receptors;
(2) adoption, irrespective of the stress experience of the foster mother,
reverses the effects of prenatal stress; and (3) adoption per se increases
maternal behavior and decreases the stress- induced corticosterone
secretion peak in the adult offspring. In conclusion, certain prenatal and
postnatal manipulations appear to have opposite long-term effects on the
activity of the HPA axis, and adoption, probably by modifying maternal
behavior, can protect against the effects of prenatal stress. Thus, changes
in the activity of the HPA axis may be one of the biological substrates of
the long-term effects of certain perinatal events.
This article has been cited by other articles:
|
|
|
|
 
K. Z LeWinn, L. R Stroud, B. E Molnar, J. H Ware, K. C Koenen, and S. L Buka
Elevated maternal cortisol levels during pregnancy are associated with reduced childhood IQ
Int. J. Epidemiol.,
December 1, 2009;
38(6):
1700 - 1710.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Hu, E. J. Crespi, and R. J. Denver
Programming Neuroendocrine Stress Axis Activity by Exposure to Glucocorticoids during Postembryonic Development of the Frog, Xenopus laevis
Endocrinology,
November 1, 2008;
149(11):
5470 - 5481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Nakamura, T. Kikusui, Y. Takeuchi, and Y. Mori
Influences of Pre- and Postnatal Early Life Environments on the Inhibitory Properties of Familiar Urine Odors in Male Mouse Aggression
Chem Senses,
July 1, 2008;
33(6):
541 - 551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mairesse, J. Lesage, C. Breton, B. Breant, T. Hahn, M. Darnaudery, S. L. Dickson, J. Seckl, B. Blondeau, D. Vieau, et al.
Maternal stress alters endocrine function of the feto-placental unit in rats
Am J Physiol Endocrinol Metab,
June 1, 2007;
292(6):
E1526 - E1533.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S E Chadio, B Kotsampasi, G Papadomichelakis, S Deligeorgis, D Kalogiannis, I Menegatos, and G Zervas
Impact of maternal undernutrition on the hypothalamic-pituitary-adrenal axis responsiveness in sheep at different ages postnatal
J. Endocrinol.,
March 1, 2007;
192(3):
495 - 503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kanitz, W. Otten, and M. Tuchscherer
Changes in endocrine and neurochemical profiles in neonatal pigs prenatally exposed to increased maternal cortisol.
J. Endocrinol.,
October 1, 2006;
191(1):
207 - 220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. N. Richardson, E. P. Zorrilla, C. D. Mandyam, and C. L. Rivier
Exposure to Repetitive Versus Varied Stress during Prenatal Development Generates Two Distinct Anxiogenic and Neuroendocrine Profiles in Adulthood
Endocrinology,
May 1, 2006;
147(5):
2506 - 2517.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Shoener, R. Baig, and K. C. Page
Prenatal exposure to dexamethasone alters hippocampal drive on hypothalamic-pituitary-adrenal axis activity in adult male rats
Am J Physiol Regulatory Integrative Comp Physiol,
May 1, 2006;
290(5):
R1366 - R1373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Holmes, C. T. Abrahamsen, K. L. French, J. M. Paterson, J. J. Mullins, and J. R. Seckl
The mother or the fetus? 11beta-hydroxysteroid dehydrogenase type 2 null mice provide evidence for direct fetal programming of behavior by endogenous glucocorticoids.
J. Neurosci.,
April 5, 2006;
26(14):
3840 - 3844.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kapoor, E. Dunn, A. Kostaki, M. H. Andrews, and S. G. Matthews
Fetal programming of hypothalamo-pituitary-adrenal function: prenatal stress and glucocorticoids
J. Physiol.,
April 1, 2006;
572(1):
31 - 44.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. H. Son, D. Geum, S. Chung, E. J. Kim, J.-H. Jo, C.-M. Kim, K. H. Lee, H. Kim, S. Choi, H. T. Kim, et al.
Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.
J. Neurosci.,
March 22, 2006;
26(12):
3309 - 3318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chung, G. H. Son, S. H. Park, E. Park, K. H. Lee, D. Geum, and K. Kim
Differential Adaptive Responses to Chronic Stress of Maternally Stressed Male Mice Offspring
Endocrinology,
July 1, 2005;
146(7):
3202 - 3210.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K R Poore and A L Fowden
The effect of birth weight on hypothalamo-pituitary-adrenal axis function in juvenile and adult pigs
J. Physiol.,
February 15, 2003;
547(1):
107 - 116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Francis, J. Diorio, P. M. Plotsky, and M. J. Meaney
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
J. Neurosci.,
September 15, 2002;
22(18):
7840 - 7843.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Dugovic, S. Maccari, L. Weibel, F. W. Turek, and a. O. Van Reeth
High Corticosterone Levels in Prenatally Stressed Rats Predict Persistent Paradoxical Sleep Alterations
J. Neurosci.,
October 1, 1999;
19(19):
8656 - 8664.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. R. de Kloet, E. Vreugdenhil, M. S. Oitzl, and M. Joëls
Brain Corticosteroid Receptor Balance in Health and Disease
Endocr. Rev.,
June 1, 1998;
19(3):
269 - 301.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. C. Day, M. Koehl, V. Deroche, M. Le Moal, and S. Maccari
Prenatal Stress Enhances Stress- and Corticotropin-Releasing Factor-Induced Stimulation of Hippocampal Acetylcholine Release in Adult Rats
J. Neurosci.,
March 1, 1998;
18(5):
1886 - 1892.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Muneoka, M. Mikuni, T. Ogawa, K. Kitera, K. Kamei, M. Takigawa, and K. Takahashi
Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring
Am J Physiol Regulatory Integrative Comp Physiol,
November 1, 1997;
273(5):
R1669 - R1675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Barbazanges, M. Vallee, W. Mayo, J. Day, H. Simon, M. Le Moal, and S. Maccari
Early and Later Adoptions Have Different Long-Term Effects on Male Rat Offspring
J. Neurosci.,
December 1, 1996;
16(23):
7783 - 7790.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Barbazanges, P. V. Piazza, M. Le Moal, and S. Maccari
Maternal Glucocorticoid Secretion Mediates Long-Term Effects of Prenatal Stress
J. Neurosci.,
June 15, 1996;
16(12):
3943 - 3949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
