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Journal of Neuroscience, Vol 15, 7196-7200, Copyright © 1995 by Society for Neuroscience
Cyclic-GMP enhances light-induced excitation and induces membrane currents in Drosophila retinal photoreceptors
J Bacigalupo, DM Bautista, DL Brink, JF Hetzer and PM O'Day
Universidad de Chile, Facultad de Ciencias, Departamento de Biologia, Santiago, Chile.
Phototransduction in the Drosophila retina appears to require the
phosphoinositide signaling cascade following receptor/G-protein activation.
Subsequent opening of membrane cationic channels causes excitation. The
biochemical events underlying channel opening and regulation of sensitivity
remain largely unknown. Evidence is mounting that phototransduction in
Drosophila and other invertebrate species may additionally involve the
second messenger, cyclic-GMP (cGMP). We report that exogenous cGMP
influenced Drosophila retinal phototransduction in two ways. In whole cell
tight-seal voltage-clamp experiments, membrane permeant cGMP analog,
8-bromo-cyclic-GMP (8-Br-cGMP), induced membrane currents and dramatically
enhanced light-induced currents. The currents induced by 8-Br-cGMP
possessed reversal potentials similar to those induced by light. The
magnitudes of cGMP-induced currents exhibited marked dependence on
intensity of background illumination. Potential direct or modulatory roles
of cGMP in Drosophila phototransduction are discussed.
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