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Journal of Neuroscience, Vol 15, 7769-7777, Copyright © 1995 by Society for Neuroscience
The migration of luteinizing hormone-releasing hormone neurons in the developing rat is associated with a transient, caudal projection of the vomeronasal nerve
K Yoshida, SA Tobet, JE Crandall, TP Jimenez and GA Schwarting
Shriver Center, Waltham, Massachusetts 02154, USA.
Luteinizing hormone-releasing hormone (LHRH) neurons originate in the
olfactory placode and vomeronasal organ and migrate to the brain from
embryonic day 14 (E14) in the rat. We investigated the development of the
vomeronasal nerve and its role as a guide for migrating LHRH neurons. Using
fluorescent, lipophilic dye tracing methods, we observed axons that emerge
from the vomeronasal organ and cross the nasal septum as several large
fascicles. At E14-15, these fascicles converge as they enter the region of
the cribriform plate and subsequently disperse, projecting dorsally and
caudally across the olfactory bulb and rostral forebrain. At E16, the
dorsal branch of the vomeronasal nerve forms a more tightly fasciculated
projection; the caudal fibers remain dispersed, extending along the medial
forebrain. The number of caudally directed axons decreases during
development, leaving four or five present at postnatal day 4 (P4).
Immunohistochemical studies indicate that the vomeronasal nerve can be
divided into four spatially distinct subpopulations of fibers. One subset,
composed of caudal fibers that terminate in the lamina terminalis,
selectively expresses TAG-1, a transient axonal surface glycoprotein and
PSA-N-CAM, a highly polysialated form of neural cell adhesion molecule. The
extension and subsequent retraction of this branch of the vomeronasal nerve
corresponds spatially and temporally with the migration of LHRH neurons
from the nasal cavity to the brain. Our studies show that between E14 and
E18, LHRH neurons migrate in contact with the TAG-1+, PSA-N-CAM+ caudal
branch of the vomeronasal nerve.
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