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Journal of Neuroscience, Vol 15, 1249-1260, Copyright © 1995 by Society for Neuroscience
Presynaptic enhancement of inhibitory synaptic transmission by protein kinases A and C in the rat hippocampus in vitro
M Capogna, BH Gahwiler and SM Thompson
Brain Research Institute, University of Zurich, Switzerland.
The protein kinase C activator phorbol 12,13-dibutyrate (0.5 microM, PDBu)
and the protein kinase A activator forskolin (20 microM) each increased
evoked monosynaptic inhibitory postsynaptic current (IPSC) amplitude,
without affecting its reversal potential, and increased the frequency of
miniature IPSCs (mIPSCs), without affecting their amplitude or kinetics, as
assessed with whole-cell recording form CA3 pyramidal cells in hippocampal
slice cultures. The effects of forskolin and PDBu on both evoked IPSC
amplitude and mIPSC frequency were additive and were antagonized by
inhibitors of protein kinases A and C, respectively. The kinase
activator-induced increases in mIPSC frequency were quantitatively
comparable to the increases in evoked IPSC amplitude. The increases in
mIPSC frequency were not attenuated by the voltage-dependent calcium
channel blocker Cd2+ (100 microM). We conclude that stimulation of protein
kinases A and C potentiates hippocampal inhibitory synaptic transmission
through independent presynaptic mechanisms of action. Kinase-induced
potentiation of spontaneous release does not require modulation of axon
terminal Ca2+ channels. This mechanism may also contribute substantially to
the potentiation of evoked release.
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