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Journal of Neuroscience, Vol 15, 1755-1767, Copyright © 1995 by Society for Neuroscience
Central projections of sensory neurons in the Drosophila embryo correlate with sensory modality, soma position, and proneural gene function
DJ Merritt and PM Whitington
Department of Zoology, University of New England, Amidale, New South Wales, Australia.
The peripheral nervous system (PNS) of the Drosophila embryo is especially
suited for investigating the specification of neuronal identity: the PNS
consists of a relatively simple but diverse set of individually identified
sensory neurons; mutants, including embryonic lethals, can be readily
generated and analyzed; and axon growth can potentially be followed from
the earliest stages. We have developed a staining method to reveal the
central projections of the full set of sensory neurons in the preterminal
abdominal segments of the embryo. The sensory neurons exhibit
modality-specific axonal projections in the CNS. The axons of external
sense (es) organ neurons, primarily tactile in function, are restricted to
a particular region within each neuromere and exhibit a somatotopic mapping
within the CNS. The axons of stretch-receptive chordotonal (ch) organs
project into a discrete longitudinal fascicle. Sensory neurons with
multiple-branched dendrites (md neurons) project into a separate fascicle.
A small number of md neurons have distinctive dorsal-projecting axonal
processes in the CNS. A classification of sensory neurons based on their
axon morphology correlates closely with the identity of the proneural gene
responsible for their generation, suggesting that proneural genes play a
central role in determining neuronal identity in the PNS of the embryo.
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