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Journal of Neuroscience, Vol 15, 1912-1939, Copyright © 1995 by Society for Neuroscience
Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems
M Zoli, N Le Novere, JA Hill Jr and JP Changeux
URA CNRS D1284, Institut Pasteur, Paris, France.
In the present study we have investigated the anatomical distribution
pattern of nAChR alpha 3, alpha 4, beta 2, and beta 4 subunit mRNAs during
prenatal and perinatal development of the rat CNS and PNS. Three main
developmental patterns have been recognized. (1) In the majority of cases
studied (caudal brain, spinal cord, dorsal root ganglia, trigeminal and
geniculate ganglia) all four subunit mRNAs are initially (E11-13) detected
but, during subsequent prenatal development, the level of some of these
subunit mRNAs (alpha 3 and beta 4 in the brain and spinal cord, alpha 4 and
beta 4 in the dorsal root ganglia, alpha 4 in the visceral sensory ganglia,
and alpha 3, alpha 4, and beta 4 in the somatic sensory ganglia) become
undetectable. (2) In the case of the cerebral cortex a pair of subunit
mRNAs (alpha 3-beta 2) is initially (E12-13) expressed followed by a
repression of the alpha 3 subunit (E15) and the subsequent (E17-19)
induction of the alpha 4 subunit. (3) Only some subunit mRNAs are initially
(E13-15) expressed in the retina (alpha 3-alpha 4-beta 2-beta 4),
parasympathetic or sympathetic motor ganglia (alpha 3-beta 2-beta 4), and
vestibulo- cochlear ganglia (alpha 4-beta 2) and their level remains stable
throughout prenatal and early postnatal development. Overall, in most
central and peripheral structures the appearance of nAChR subunit mRNAs is
precocious and temporally related to the timing of neuronal
differentiation. In addition, in several structures the expression of
certain subunits (alpha 3, alpha 4 or beta 4) is transient, although not
beta 2. Finally, the comparison of the different regional distribution
patterns suggests that a limited number of structure- specific receptor
isoforms are functional during development of CNS and PNS.
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