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Journal of Neuroscience, Vol 15, 1998-2012, Copyright © 1995 by Society for Neuroscience
Central neuronal circuit innervating the rat heart defined by transneuronal transport of pseudorabies virus
A Standish, LW Enquist, JA Escardo and JS Schwaber
Neural Computation Group, E. I. DuPont de Nemours and Company, Wilmington, Delaware 19880-0328.
We defined the central circuit innervating various regions of the rat heart
using a neurotropic herpesvirus as a transneuronal tracer. Location of
viral antigens in the brain after cardiac injection of three strains of
pseudorabies virus (PRV) provided insight into vagal preganglionic neurons
and their connected interneurons. At short survival times, labeled vagal
preganglionic neurons were localized in both the nucleus ambiguus (NA) and
the dorsal motor nucleus of the vagus (DMV), and in an arc-like band
through the reticular formation between the NA and the DMV. The amount of
DMV labeling was dependent on viral strain. Similar distributions of
labeled neurons were observed following either ganglionic, sinoatrial node,
or ventricular injections. At intermediate survival times postcardiac
injection, the virus replicated in vagal preganglionic neurons and was
trans- synaptically transported to interneurons observed primarily in the
NA regions and in an arc-like band through the reticular formation. Labeled
neurons were also observed in ventral regions of the nucleus of the
solitary tract (NTS). At longer survival times, labeled neurons were found
in various regions of the NTS with the most abundant label dorsal and
dorsomedial to the solitary tract. Abundant neuronal labeling was also
found in the intermediolateral cell column, the raphe nuclei, the caudal
and rostral ventral lateral medulla, the A5 region, the locus coeruleus,
and the lateral and paraventricular hypothalamic nuclei. These data define
the central circuits including the interneuronal connections that innervate
various cardiac targets.
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