 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 3138-3153, Copyright © 1995 by Society for Neuroscience
Recordings from slices indicate that octopus cells of the cochlear nucleus detect coincident firing of auditory nerve fibers with temporal precision
NL Golding, D Robertson and D Oertel
Department of Neurophysiology, University of Wisconsin, Madison 53706, USA.
Acoustic information in auditory nerve discharges is integrated in the
cochlear nuclei, and ascends through several parallel pathways to higher
centers. Octopus cells of the posteroventral cochlear nucleus form a
pathway known to carry information in the timing of action potentials.
Octopus cells have dendrites oriented to receive converging input from many
auditory nerve fibers. In all 34 intracellular recordings from anatomically
identified octopus cells in slices, shocks to the auditory nerve evoked
brief, consistent, graded EPSPs. EPSPs were about 1 msec in duration. At
all but the lowest shock strengths, the delays between shocks and the peaks
of resultant EPSPs had SDs of 0.02 msec. Polysynaptic excitation, perhaps
arising from the axon collaterals of octopus cells, was observed. No
detectable glycinergic or GABAergic inhibition was evoked with shocks. The
input resistances were low, around 10 M omega, voltage changes were rapid,
with time constants of about 1 msec, and action potentials were small. The
low input resistance resulted in part from a Cs(+)-sensitive conductance.
In the presence of 10 or 15 mM extracellular Cs+ the time constants
increased 20-fold in the hyperpolarizing voltage range. As several
subthreshold inputs were required to produce suprathreshold responses,
octopus cells detect the coincident firing of auditory nerve fibers. Under
physiological conditions the low input resistance and resulting short time
constant limit the time over which temporal summation of excitation from
auditory nerve fibers can occur and thus provide temporal precision to
electrical signaling.
This article has been cited by other articles:
|
|
|
|
 
S. Huggenberger, M. Vater, and R. A. Deisz
Interlaminar Differences of Intrinsic Properties of Pyramidal Neurons in the Auditory Cortex of Mice
Cereb Cortex,
May 1, 2009;
19(5):
1008 - 1018.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Rusznak, G. Bakondi, K. Pocsai, A. Por, L. Kosztka, B. Pal, D. Nagy, and G. Szucs
Voltage-gated Potassium Channel (Kv) Subunits Expressed in the Rat Cochlear Nucleus
J. Histochem. Cytochem.,
May 1, 2008;
56(5):
443 - 465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. V. Portfors and P. D. Roberts
Temporal and Frequency Characteristics of Cartwheel Cells in the Dorsal Cochlear Nucleus of the Awake Mouse
J Neurophysiol,
August 1, 2007;
98(2):
744 - 756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-J. Cao, S. Shatadal, and D. Oertel
Voltage-Sensitive Conductances of Bushy Cells of the Mammalian Ventral Cochlear Nucleus
J Neurophysiol,
June 1, 2007;
97(6):
3961 - 3975.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ashida, K. Abe, K. Funabiki, and M. Konishi
Passive Soma Facilitates Submillisecond Coincidence Detection in the Owl's Auditory System
J Neurophysiol,
March 1, 2007;
97(3):
2267 - 2282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. X. Gittelman and B. L Tempel
Kv1.1-Containing Channels Are Critical for Temporal Precision During Spike Initiation
J Neurophysiol,
September 1, 2006;
96(3):
1203 - 1214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. A. Rodrigues and D. Oertel
Hyperpolarization-Activated Currents Regulate Excitability in Stellate Cells of the Mammalian Ventral Cochlear Nucleus
J Neurophysiol,
January 1, 2006;
95(1):
76 - 87.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Hurley and G. D. Pollak
Serotonin Shifts First-Spike Latencies of Inferior Colliculus Neurons
J. Neurosci.,
August 24, 2005;
25(34):
7876 - 7886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. X. Nayagam, J. C. Clarey, and A. G. Paolini
Powerful, Onset Inhibition in the Ventral Nucleus of the Lateral Lemniscus
J Neurophysiol,
August 1, 2005;
94(2):
1651 - 1654.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-J. Cao and D. Oertel
Temperature Affects Voltage-Sensitive Conductances Differentially in Octopus Cells of the Mammalian Cochlear Nucleus
J Neurophysiol,
July 1, 2005;
94(1):
821 - 832.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F.-G. Zeng, Y.-Y. Kong, H. J. Michalewski, and A. Starr
Perceptual Consequences of Disrupted Auditory Nerve Activity
J Neurophysiol,
June 1, 2005;
93(6):
3050 - 3063.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. MacLeod and C. E. Carr
Synaptic Physiology in the Cochlear Nucleus Angularis of the Chick
J Neurophysiol,
May 1, 2005;
93(5):
2520 - 2529.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Koch and B. Grothe
Hyperpolarization-Activated Current (Ih) in the Inferior Colliculus: Distribution and Contribution to Temporal Processing
J Neurophysiol,
December 1, 2003;
90(6):
3679 - 3687.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. P. Bowen, D. Lin, M. K. Taylor, and J. R. Ison
Auditory Cortex Lesions in the Rat Impair Both Temporal Acuity and Noise Increment Thresholds, Revealing a Common Neural Substrate
Cereb Cortex,
August 1, 2003;
13(8):
815 - 822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Rothman and P. B. Manis
Differential Expression of Three Distinct Potassium Currents in the Ventral Cochlear Nucleus
J Neurophysiol,
June 1, 2003;
89(6):
3070 - 3082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. M Brew, J. L Hallows, and B. L Tempel
Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1
J. Physiol.,
April 1, 2003;
548(1):
1 - 20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Fujino and D. Oertel
Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus
PNAS,
January 7, 2003;
100(1):
265 - 270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Soares, R. A. Chitwood, R. L. Hyson, and C. E. Carr
Intrinsic Neuronal Properties of the Chick Nucleus Angularis
J Neurophysiol,
July 1, 2002;
88(1):
152 - 162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Behrend, A. Brand, C. Kapfer, and B. Grothe
Auditory Response Properties in the Superior Paraolivary Nucleus of the Gerbil
J Neurophysiol,
June 1, 2002;
87(6):
2915 - 2928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Ferragamo and D. Oertel
Octopus Cells of the Mammalian Ventral Cochlear Nucleus Sense the Rate of Depolarization
J Neurophysiol,
May 1, 2002;
87(5):
2262 - 2270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kuba, K. Koyano, and H. Ohmori
Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chicken
J. Physiol.,
April 15, 2002;
540(2):
529 - 542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Brenowitz and L. O. Trussell
Maturation of Synaptic Transmission at End-Bulb Synapses of the Cochlear Nucleus
J. Neurosci.,
December 1, 2001;
21(23):
9487 - 9498.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Bal and D. Oertel
Potassium Currents in Octopus Cells of the Mammalian Cochlear Nucleus
J Neurophysiol,
November 1, 2001;
86(5):
2299 - 2311.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Fujino and D. Oertel
Cholinergic Modulation of Stellate Cells in the Mammalian Ventral Cochlear Nucleus
J. Neurosci.,
September 15, 2001;
21(18):
7372 - 7383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Gardner, L. O. Trussell, and D. Oertel
Correlation of AMPA Receptor Subunit Composition with Synaptic Input in the Mammalian Cochlear Nuclei
J. Neurosci.,
September 15, 2001;
21(18):
7428 - 7437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Lu and L. O Trussell
Mixed excitatory and inhibitory GABA-mediated transmission in chick cochlear nucleus
J. Physiol.,
August 15, 2001;
535(1):
125 - 131.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Oertel, R. Bal, S. M. Gardner, P. H. Smith, and P. X. Joris
Detection of synchrony in the activity of auditory nerve fibers by octopus cells of the mammalian cochlear nucleus
PNAS,
October 24, 2000;
97(22):
11773 - 11779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Bal and D. Oertel
Hyperpolarization-Activated, Mixed-Cation Current (Ih) in Octopus Cells of the Mammalian Cochlear Nucleus
J Neurophysiol,
August 1, 2000;
84(2):
806 - 817.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Cai, J. McGee, and E. J. Walsh
Contributions of Ion Conductances to the Onset Responses of Octopus Cells in the Ventral Cochlear Nucleus: Simulation Results
J Neurophysiol,
January 1, 2000;
83(1):
301 - 314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Gardner, L. O. Trussell, and D. Oertel
Time Course and Permeation of Synaptic AMPA Receptors in Cochlear Nuclear Neurons Correlate with Input
J. Neurosci.,
October 15, 1999;
19(20):
8721 - 8729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Wu
Physiological Properties of Neurons in the Ventral Nucleus of the Lateral Lemniscus of the Rat: Intrinsic Membrane Properties and Synaptic Responses
J Neurophysiol,
June 1, 1999;
81(6):
2862 - 2874.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. L. Golding, M. J. Ferragamo, and D. Oertel
Role of Intrinsic Conductances Underlying Responses to Transients in Octopus Cells of the Cochlear Nucleus
J. Neurosci.,
April 15, 1999;
19(8):
2897 - 2905.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Ferragamo, N. L. Golding, and D. Oertel
Synaptic Inputs to Stellate Cells in the Ventral Cochlear Nucleus
J Neurophysiol,
January 1, 1998;
79(1):
51 - 63.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Cai, E. J. Walsh, and J. McGee
Mechanisms of Onset Responses in Octopus Cells of the Cochlear Nucleus: Implications of a Model
J Neurophysiol,
August 1, 1997;
78(2):
872 - 883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. L. Golding and D. Oertel
Physiological Identification of the Targets of Cartwheel Cells in the Dorsal Cochlear Nucleus
J Neurophysiol,
July 1, 1997;
78(1):
248 - 260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kuba, K. Koyano, and H. Ohmori
Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chicken
J. Physiol.,
April 15, 2002;
540(2):
529 - 542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
