 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 4408-4416, Copyright © 1995 by Society for Neuroscience
Androgen alters the dendritic arbors of SNB motoneurons by acting upon their target muscles
MN Rand and SM Breedlove
Department of Psychology, University of California, Berkeley 94720- 1650, USA.
In adult male rats, motoneurons of the spinal nucleus of the
bulbocavernosus (SNB) have been shown to retract and reextend their
dendritic branches in response to systemic androgen deprivation and
readministration. Furthermore, other studies have suggested that the
dendritic complexity of neurons can be regulated by their targets. To
assess whether androgens might act upon the target muscles to mediate
changes in SNB dendrites, adult male rats were castrated and implanted with
a small capsule filled with testosterone (T) next to the bulbocavernosus
and levator ani muscle complex (BC/LA) on one side, while the muscles on
the contralateral side were implanted with another capsule containing
hydroxyflutamide (hFl), an anti-androgen. We have previously shown that
after 30 d of this focused, lateralized androgen treatment the BC/LA
complex is significantly larger on the T-treated side. We now report that
the total dendritic lengths of SNB motoneurons innervating muscles given
androgen blockade are reduced by 44% compared to SNB motoneurons
innervating muscles given androgen stimulation. Dendrite lengths within
three regions of the spinal cord were altered in a nonuniform manner: large
changes occurred in the dorsal and contralateral dendritic fields while
there was no difference in the ipsilateral dendritic field. These results
suggest that BC/LA muscles, in response to androgen stimulation, produce a
trophic substance which regulates the dendritic organization of SNB
motoneurons in adulthood.
This article has been cited by other articles:
|
|
|
|
 
E. N. Ottem, L. A. Beck, C. L. Jordan, and S. M. Breedlove
Androgen-Dependent Regulation of Brain-Derived Neurotrophic Factor and Tyrosine Kinase B in the Sexually Dimorphic Spinal Nucleus of the Bulbocavernosus
Endocrinology,
August 1, 2007;
148(8):
3655 - 3665.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Rose
Morphological and functional maturation of a skeletal muscle regulated by juvenile hormone
J. Exp. Biol.,
February 1, 2004;
207(3):
483 - 495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Y. Yang, T. Verhovshek, and D. R. Sengelaub
Brain-Derived Neurotrophic Factor and Androgen Interact in the Maintenance of Dendritic Morphology in a Sexually Dimorphic Rat Spinal Nucleus
Endocrinology,
January 1, 2004;
145(1):
161 - 168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Burnett
Neurophysiology of Erectile Function: Androgenic Effects
J Androl,
November 1, 2003;
24(6_suppl):
S2 - S5.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Jordan, S. E. Christensen, R. J. Handa, J. L. Anderson, W. A. Pouliot, and S. M. Breedlove
Evidence That Androgen Acts Through NMDA Receptors to Affect Motoneurons in the Rat Spinal Nucleus of the Bulbocavernosus
J. Neurosci.,
November 1, 2002;
22(21):
9567 - 9572.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Rose, M. Ferber, and R. Hustert
Maturation of muscle properties and its hormonal control in an adult insect
J. Exp. Biol.,
March 12, 2002;
204(20):
3531 - 3545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. V. Watson, L. M. Freeman, and S. M. Breedlove
Neuronal Size in the Spinal Nucleus of the Bulbocavernosus: Direct Modulation by Androgen in Rats with Mosaic Androgen Insensitivity
J. Neurosci.,
February 1, 2001;
21(3):
1062 - 1066.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Schultz and B. A. Schlinger
Widespread accumulation of [3H]testosterone in the spinal cord of a wild bird with an elaborate courtship display
PNAS,
August 31, 1999;
96(18):
10428 - 10432.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Ostby, W. R. Kelce, C. Lambright, C. J. Wolf, P. Mann, and L. E. Gray Jr.
The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
Toxicology and Industrial Health,
February 1, 1999;
15(1-2):
80 - 93.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. G. Forger, C. K. Wagner, M. Contois, L. Bengston, and A. J. MacLennan
Ciliary Neurotrophic Factor Receptor alpha in Spinal Motoneurons is Regulated by Gonadal Hormones
J. Neurosci.,
November 1, 1998;
18(21):
8720 - 8729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
