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Journal of Neuroscience, Vol 15, 5308-5315, Copyright © 1995 by Society for Neuroscience
Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning
RG Phillips and JE LeDoux
Department of Psychology, New York University, New York 10003, USA.
The effects of entorhinal cortex lesions, combined entorhinal and
perirhinal cortex lesions, and fornix lesions on the conditioning of fear
responses (freezing) to contextual stimuli were examined using a
conditioning procedure known to produce hippocampal-dependent contextual
conditioning. Lesions of the entorhinal and or entorhinal plus perirhinal
cortex did not disrupt contextual conditioning, but lesions of the fornix
did. None of the lesions affected conditioning to an explicit conditioned
stimulus. Given that the entorhinal cortex is the primary linkage between
the neocortex and the hippocampus and that the fornix is the primary
linkage with subcortical structures, subcortical inputs to and outputs of
the hippocampus appear to be sufficient to mediate contextual fear
conditioning. As a result, the presumption that neocortical information is
required for contextual fear conditioning, and perhaps other
hippocampal-dependent functions, should be reevaluated.
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