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Journal of Neuroscience, Vol 15, 5789-5799, Copyright © 1995 by Society for Neuroscience
Regional expression and cellular localization of the Na(+)-dependent inorganic phosphate cotransporter of rat brain
B Ni, X Wu, GM Yan, J Wang and SM Paul
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
We have recently isolated and identified a brain specific Na(+)- dependent
inorganic phosphate (Pi) cotransporter cDNA (rBNPI) from a rat brain cDNA
library (Ni, et al., 1994). We now report the regional and developmental
expression, as well as the cellular localization, of rBNPI mRNA in the rat
brain. In situ hybridization histochemistry reveals that rBNPI mRNA is
selectively expressed in neuron-enriched regions of the adult rat brain,
such as the cerebral cortex, hippocampus, and cerebellum. Cellular
localization of rBNPI transcripts reveals expression in both pyramidal and
granule neurons in these regions. By contrast, little to no hybridization
signal was observed in white matter-enriched areas such as the corpus
callosum. The expression of rBNPI mRNA was determined during pre- and
postnatal development of the rat CNS. From embryonic day 17 to early
postnatal day 10 (PND 10), there is a rather widespread but diffuse pattern
of rBNPI expression in brain. During late postnatal development, however,
the expression of rBNPI mRNA becomes confined to discrete populations of
neurons in the cerebral cortex, hippocampus, and cerebellum. Thus, rBNPI
expression is developmentally regulated and abundant levels of mRNA are
found in rather discrete populations of neurons in the adult rat brain. The
latter suggests that rBNPI may serve to selectively regulate intracellular
Pi transport in certain neurons for either metabolic and (or) signaling
events.
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