 |
Next Article 
Journal of Neuroscience, Vol 15, 5859-5869, Copyright © 1995 by Society for Neuroscience
Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area
SA Oakman, PL Faris, PE Kerr, C Cozzari and BK Hartman
Graduate Program in Neuroscience, University of Minnesota, Minneapolis 55455, USA.
Locations of pontomesencephalic cholinergic projection neurons from the
laterodorsal tegmental (LDTg) and pedunculopontine tegmental (PPTg) nuclei
to midbrain dopaminergic nuclei were mapped. Stereotaxic microinjections of
Fluoro-Gold- or rhodamine-labeled microspheres were made either to
substantia nigra (SN) or ventral tegmental area (VTA) in rat. Choline
acetyltransferase was visualized immunohistochemically. Labeled cells were
digitally mapped at multiple levels of the nuclei using an interactive
computer/microscope system. SN-projecting neurons were distributed
predominantly ipsilaterally in distinct regions of the PPTg: either at its
rostral pole or caudally in an area ventromedial to the superior cerebellar
peduncle. Few SN-projecting neurons were found in LDTg. VTA-projecting
neurons were distributed bilaterally throughout the cholinergic group,
primarily in the densest regions of the LDTg and caudal PPTg. Neurons were
not strictly segregated into these patterns. Scattered cells belonging to
either projection could be found throughout the cholinergic group on either
side. Hierarchical log- linear analysis showed these differences in
topographic distribution to be statistically significant. Subtraction of
cell density images demonstrated well delineated regions of the cholinergic
group where the projections were predominately either to SN or VTA. These
data indicate a high degree of internal organization within the
pontomesencephalic cholinergic group based on the location of efferent
projections to SN or VTA. These findings support the concept that this
cholinergic group is functionally organized in a manner which selectively
innervates motor (SN) and limbic (VTA) dopaminergic nuclei.
This article has been cited by other articles:
|
|
|
|
 
Z.-B. You, B. Wang, D. Zitzman, and R. A. Wise
Acetylcholine Release in the Mesocorticolimbic Dopamine System during Cocaine Seeking: Conditioned and Unconditioned Contributions to Reward and Motivation
J. Neurosci.,
September 3, 2008;
28(36):
9021 - 9029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Nelson, M. Mattingly, S. A. Lee, and F. A. Schmitt
Does the arousal system contribute to near death experience?
Neurology,
April 11, 2006;
66(7):
1003 - 1009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Lodge and A. A. Grace
The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons
PNAS,
March 28, 2006;
103(13):
5167 - 5172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto, M. Qin, and Z.-H. Liu
Primary Reinforcing Effects of Nicotine Are Triggered from Multiple Regions Both Inside and Outside the Ventral Tegmental Area
J. Neurosci.,
January 18, 2006;
26(3):
723 - 730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Thomsen, D. P. D. Woldbye, G. Wortwein, A. Fink-Jensen, J. Wess, and S. B. Caine
Reduced Cocaine Self-Administration in Muscarinic M5 Acetylcholine Receptor-Deficient Mice
J. Neurosci.,
September 7, 2005;
25(36):
8141 - 8149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. LARSSON, L. EDSTROM, L. SVENSSON, B. SODERPALM, and J. A. ENGEL
VOLUNTARY ETHANOL INTAKE INCREASES EXTRACELLULAR ACETYLCHOLINE LEVELS IN THE VENTRAL TEGMENTAL AREA IN THE RAT
Alcohol Alcohol.,
September 1, 2005;
40(5):
349 - 358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. W. Jones and S. Wonnacott
Precise Localization of {alpha}7 Nicotinic Acetylcholine Receptors on Glutamatergic Axon Terminals in the Rat Ventral Tegmental Area
J. Neurosci.,
December 15, 2004;
24(50):
11244 - 11252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto and R. A. Wise
Rewarding Effects of the Cholinergic Agents Carbachol and Neostigmine in the Posterior Ventral Tegmental Area
J. Neurosci.,
November 15, 2002;
22(22):
9895 - 9904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Laviolette, T. O. Alexson, and D. van der Kooy
Lesions of the Tegmental Pedunculopontine Nucleus Block the Rewarding Effects and Reveal the Aversive Effects of Nicotine in the Ventral Tegmental Area
J. Neurosci.,
October 1, 2002;
22(19):
8653 - 8660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Basile, I. Fedorova, A. Zapata, X. Liu, T. Shippenberg, A. Duttaroy, M. Yamada, and J. Wess
Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia
PNAS,
August 20, 2002;
99(17):
11452 - 11457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Picciotto and W. A. Corrigall
Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics
J. Neurosci.,
May 1, 2002;
22(9):
3338 - 3341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Burlet, C. J. Tyler, and C. S. Leonard
Direct and Indirect Excitation of Laterodorsal Tegmental Neurons by Hypocretin/Orexin Peptides: Implications for Wakefulness and Narcolepsy
J. Neurosci.,
April 1, 2002;
22(7):
2862 - 2872.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Henderson, K. Carpenter, H. Cartwright, and G. M. Halliday
Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications
Brain,
July 1, 2000;
123(7):
1410 - 1421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. B. Carr and S. R. Sesack
Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons
J. Neurosci.,
May 15, 2000;
20(10):
3864 - 3873.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Olmstead, E. M. Munn, K. B. J. Franklin, and R. A. Wise
Effects of Pedunculopontine Tegmental Nucleus Lesions on Responding for Intravenous Heroin under Different Schedules of Reinforcement
J. Neurosci.,
July 1, 1998;
18(13):
5035 - 5044.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. A. Pedersen, Q. Guo, B. K. Hartman, and M. P. Mattson
Nerve Growth Factor-independent Reduction in Choline Acetyltransferase Activity in PC12 Cells Expressing Mutant Presenilin-1
J. Biol. Chem.,
September 5, 1997;
272(36):
22397 - 22400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. L. Forster, J. S. Yeomans, J. Takeuchi, and C. D. Blaha
M5 Muscarinic Receptors Are Required for Prolonged Accumbal Dopamine Release after Electrical Stimulation of the Pons in Mice
J. Neurosci.,
January 1, 2002;
22(1):
RC190 - RC190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
