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Journal of Neuroscience, Vol 15, 5919-5928, Copyright © 1995 by Society for Neuroscience
Activity of the beta 3 nicotinic receptor promoter is a marker of neuron fate determination during retina development
JM Matter, L Matter-Sadzinski and M Ballivet
Department of Biochemistry, University of Geneva, Switzerland.
We have previously shown that transcription of the beta 3 nicotinic
receptor gene within the chick CNS is regulated by a promoter 143 base
pairs (bp) in length. Here, we demonstrate that in the developing visual
system this promoter is active in a subset of retinal cells, the majority
of which are ganglion cells. Because the beta 3 promoter is activated very
early during retina development, it can provide a marker of ganglion cell
induction and differentiation. Transfection of neuroretina explants enabled
us to detect activity of the beta 3 promoter in premigratory cells
localized on the ventricular side of the retina. Double-labeling
experiments showed that activation of the beta 3 promoter takes place
before the last S-phase, suggesting that this particular phenotypic trait
is determined when precursor cells are still proliferating. The beta 3
phenotype is induced in about one-tenth of the total pool of retinal
progenitor cells and is stable upon changing the cellular environment. Our
study suggests that at the very early stages of retina neurogenesis, some
lineage restrictions have already occurred in the population of retinal
progenitor cells.
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