 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 15, 6077-6084, Copyright © 1995 by Society for Neuroscience
Identification of mammalian noggin and its expression in the adult nervous system
DM Valenzuela, AN Economides, E Rojas, TM Lamb, L Nunez, P Jones, NY Lp, R Espinosa 3rd, CI Brannan and DJ Gilbert
Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
The multiple roles of noggin during dorsal fate specification in Xenopus
embryos, together with noggin's ability to directly induce neural tissue,
inspired an effort to determine whether a similar molecule exists in
mammals. Here we describe the identification of human and rat noggin and
explore their expression patterns; we also localize the human NOGGIN gene
to chromosome 17q22, and the mouse gene to a syntenic region of chromosome
11. Mammalian noggin is remarkably similar in its sequence to Xenopus
noggin, and is similarly active in induction assays performed on Xenopus
embryo tissues. In the adult mammal, noggin is most notably expressed in
particular regions of the nervous system, such as the tufted cells of the
olfactory bulb, the piriform cortex of the brain, and the Purkinje cells of
the cerebellum, suggesting that one of the earliest acting neural inducers
also has important roles in the adult nervous system.
This article has been cited by other articles:
|
|
|
|
 
D. C. Wan, J. H. Pomerantz, L. J. Brunet, J.-B. Kim, Y.-F. Chou, B. M. Wu, R. Harland, H. M. Blau, and M. T. Longaker
Noggin Suppression Enhances in Vitro Osteogenesis and Accelerates in Vivo Bone Formation
J. Biol. Chem.,
September 7, 2007;
282(36):
26450 - 26459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chmielnicki, A. Benraiss, A. N. Economides, and S. A. Goldman
Adenovirally Expressed Noggin and Brain-Derived Neurotrophic Factor Cooperate to Induce New Medium Spiny Neurons from Resident Progenitor Cells in the Adult Striatal Ventricular Zone
J. Neurosci.,
March 3, 2004;
24(9):
2133 - 2142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Plikus, W. P. Wang, J. Liu, X. Wang, T.-X. Jiang, and C.-M. Chuong
Morpho-Regulation of Ectodermal Organs: Integument Pathology and Phenotypic Variations in K14-Noggin Engineered Mice through Modulation of Bone Morphogenic Protein Pathway
Am. J. Pathol.,
March 1, 2004;
164(3):
1099 - 1114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Hannallah, H. Peng, B. Young, A. Usas, B. Gearhart, and J. Huard
Retroviral Delivery of Noggin Inhibits the Formation of Heterotopic Ossification Induced by BMP-4, Demineralized Bone Matrix, and Trauma in an Animal Model
J. Bone Joint Surg. Am.,
January 1, 2004;
86(1):
80 - 91.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Glaser, A. N. Economides, L. Wang, X. Liu, R. D. Kimble, J. P. Fandl, J. M. Wilson, N. Stahl, F. S. Kaplan, and E. M. Shore
In Vivo Somatic Cell Gene Transfer of an Engineered Noggin Mutein Prevents BMP4-Induced Heterotopic Ossification
J. Bone Joint Surg. Am.,
December 1, 2003;
85(12):
2332 - 2342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Groppe, J. Greenwald, E. Wiater, J. Rodriguez-Leon, A. N. Economides, W. Kwiatkowski, K. Baban, M. Affolter, W. W. Vale, J. C. Belmonte, et al.
Structural Basis of BMP Signaling Inhibition by Noggin, a Novel Twelve-Membered Cystine Knot Protein
J. Bone Joint Surg. Am.,
August 1, 2003;
85(90003):
52 - 58.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Devlin, Z. Du, R. C. Pereira, R. B. Kimble, A. N. Economides, V. Jorgetti, and E. Canalis
Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation
Endocrinology,
May 1, 2003;
144(5):
1972 - 1978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Canalis, A. N. Economides, and E. Gazzerro
Bone Morphogenetic Proteins, Their Antagonists, and the Skeleton
Endocr. Rev.,
April 1, 2003;
24(2):
218 - 235.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Grigaliunas, R. M. Bradley, D. K. MacCallum, and C. M. Mistretta
Distinctive Neurophysiological Properties of Embryonic Trigeminal and Geniculate Neurons in Culture
J Neurophysiol,
October 1, 2002;
88(4):
2058 - 2074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. C. Pereira, A. N. Economides, and E. Canalis
Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts
Endocrinology,
December 1, 2000;
141(12):
4558 - 4563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Manolagas
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis
Endocr. Rev.,
April 1, 2000;
21(2):
115 - 137.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. C. Mabie, M. F. Mehler, and J. A. Kessler
Multiple Roles of Bone Morphogenetic Protein Signaling in the Regulation of Cortical Cell Number and Phenotype
J. Neurosci.,
August 15, 1999;
19(16):
7077 - 7088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Valenzuela, J. A. Griffiths, J. Rojas, T. H. Aldrich, P. F. Jones, H. Zhou, J. McClain, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al.
Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans
PNAS,
March 2, 1999;
96(5):
1904 - 1909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Weaver, J. Yingling, N. Dunn, S Bellusci, and B. Hogan
Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
Development,
January 9, 1999;
126(18):
4005 - 4015.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. A. McMahon, S. Takada, L. B. Zimmerman, C.-M. Fan, R. M. Harland, and A. P. McMahon
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
Genes & Dev.,
May 15, 1998;
12(10):
1438 - 1452.
[Abstract]
[Full Text]
|
|
|
|
