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Journal of Neuroscience, Vol 16, 115-122, Copyright © 1996 by Society for Neuroscience
Calcium-dependent inactivation of calcium current in synaptic terminals of retinal bipolar neurons
H von Gersdorff and G Matthews
Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794-5230, USA.
Giant synaptic terminals (approximately 10 micrometer diameter) of bipolar
neurons from goldfish retina were used to directly investigate
calcium-dependent inactivation of presynaptic calcium current. During
sustained depolarization, calcium current was initially constant for a
period lasting up to several hundred milliseconds and then it declined
exponentially. The duration of the initial delay was shorter and the rate
of inactivation was faster with larger calcium current. The fastest time
constant of inactivation (in the range of 2-5 sec) was observed under weak
calcium buffering conditions. Inactivation was attenuated when external
Ca2+ was replaced with Ba2+ and when terminals were dialyzed with high
concentrations of internal BAPTA. Elevation of intracellular calcium
concentration ([Ca2+]i) by application of the calcium ionophore ionomycin
or by dialysis with pipette solutions containing buffered elevated [Ca2+]
produced inactivation of calcium current. The rate of recovery from
inactivation was not determined by the recovery of [Ca2+]i to baseline
after a stimulus. The results demonstrate that the presynaptic calcium
current in bipolar neurons is inactivated by elevated [Ca2+]i, but the
inactivation is approximately 100-fold slower than previously described
calcium-dependent inactivation in other types of cells.
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