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Volume 16, Number 11, Issue of June 1, 1996 pp. 3571-3589
Copyright ©1996 Society for Neuroscience

Nucleus-Specific Expression of GABAA Receptor Subunit mRNAs in Monkey Thalamus

Received Jan. 19, 1996; revised March 1, 1996; accepted March 18, 1996.

M. M. Huntsman, M. G. Leggio, and E. G. Jones

Department of Anatomy and Neurobiology, University of California, Irvine, California 92717

Expression of 10 GABAA receptor subunit genes was examined in monkey thalamus by in situ hybridization using cRNA probes specific for alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, beta 1, beta 2, beta 3, gamma 1, and gamma 2 subunit mRNAs. These displayed unique hybridization patterns with significant differences from rodents. alpha 1, beta 2, and gamma 2 transcripts were expressed at high levels in all dorsal thalamic nuclei, but expression was significantly higher in sensory relay nuclei---especially the dorsal lateral geniculate nucleus. Other transcripts showed nucleus-specific differences in levels of expression and in the range expressed. alpha 5 and alpha 4 subunit transcripts were expressed in all nuclei except the intralaminar nuclei. Levels of alpha 2, alpha 3, beta 1, beta 3, and gamma 1 expression were very low, except in intralaminar nuclei. In the reticular nucleus, most subunit transcripts were not expressed, and only gamma 2 transcripts were consistently detected at modest levels. Thalamic GABAA receptors may be assembled from nucleus-specific groupings of subunit polypeptides.

Key words: in situ hybridization; alpha , beta , and gamma  subunits; inhibition; chromosomes; sensory nuclei; intralaminar nuclei




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