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Volume 16, Number 12, Issue of June 15, 1996 pp. 3887-3894
Copyright ©1996 Society for NeuroscienceBrain-Derived Neurotrophic Factor and Neurotrophin-4/5 Stimulate Growth of Axonal Branches from Regenerating Retinal Ganglion Cells
Received Jan. 1, 1996; revised March 18, 1996; accepted March 26, 1996.
Hajime Sawai, David B. Clarke, Paula Kittlerova, Garth M. Bray, and Albert J. Aguayo Centre for Research in Neuroscience, Montréal General Hospital Research Institute and McGill University, Montréal, Québec, Canada H3G 1A4
To investigate the influences of growth factors on axonal regeneration in the mammalian CNS, we used intracellular tracers to quantitate the effects of brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-4/5, or NT-3 on individual retinal ganglion cell (RGC) axons in the retinas of adult rats after optic nerve transection. A single injection of BDNF or the prolonged administration of NT-4/5 by mini-pump increased axon branch median lengths by eightfold but had no effect on the number of branches formed by the RGC axons. NT-3 did not significantly influence axonal regrowth. These specific in vivo effects of BDNF and NT-4/5 on axonal regeneration from injured RGCs may be used to promote growth and expand the abnormally small terminal arbors observed when RGCs regrow into their CNS targets.
Key words: axon branching; BDNF; NT-4/5; neurotrophins; axon regeneration; retina
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