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Volume 16, Number 15, Issue of August 1, 1996 pp. 4749-4756
Copyright ©1996 Society for NeuroscienceCompartmental Localization of a Metabotropic Glutamate Receptor (mGluR7): Two Different Active Sites at a Retinal Synapse
Received March 25, 1996; revised May 2, 1996; accepted May 7, 1996.
Johann Helmut Brandstätter1, Peter Koulen1, Rainer Kuhn2, Herman van der Putten2, and Heinz Wässle1 1 Max-Planck-Institut für Hirnforschung, Abteilung für Neuroanatomie, D-60528 Frankfurt am Main, Germany, and 2 Central Nervous System Research, CIBA, CH-4002 Basel, Switzerland
The distribution of the metabotropic glutamate receptor 7 (mGluR7) was studied in the rat retina using a specific antiserum. Punctate immunofluorescence that corresponded to synaptic localization was present exclusively in the inner plexiform layer. Double-labeling experiments suggested that mGluR7 is expressed at the synaptic terminals of certain cone bipolar cells. Electron microscopy showed that mGluR7 was present both presynaptically, as an autoreceptor in cone bipolar cell ribbon synapses, and postsynaptically in amacrine cells. There are usually two postsynaptic processes at a bipolar cell ribbon synapse; however, the presynaptic aggregation of mGluR7 was restricted to one half of the active zone and therefore was opposed to only one of the postsynaptic processes. This selective localization of mGluR7 could differentially regulate the glutamate release from the ribbon synapse, thus leading to a differential activation of the postsynaptic neurons.
Key words: cone bipolar cells; ribbon synapse; mGluR7; autoreceptor; presynaptic; postsynaptic; rat retina; retinal development
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