 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 16, Number 20, Issue of October 15, 1996 pp. 6579-6591
Copyright ©1996 Society for NeuroscienceCoordinated Expression of Dopamine Receptors in Neostriatal Medium Spiny Neurons
Received May 24, 1996; revised July 24, 1996; accepted July 26, 1996.
D. James Surmeier, Wen-Jie Song, and Zhen Yan Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis, Tennessee 38163
In recent years, the distribution of dopamine receptor subtypes among the principal neurons of the neostriatum has been the subject of debate. Conventional anatomical and physiological approaches have yielded starkly different estimates of the extent to which D1 and D2 class dopamine receptors are colocalized. One plausible explanation for the discrepancy is that some dopamine receptors are present in physiologically significant numbers, but the mRNA for these receptors is not detectable with conventional techniques. To test this hypothesis, we examined the expression of DA receptors in individual neostriatal neurons by patch-clamp and RT-PCR techniques. Because of the strong correlation between peptide expression and projection site, medium spiny neurons were divided into three groups on the basis of expression of mRNA for enkephalin (ENK) and substance P (SP). Neurons expressing detectable levels of SP but not ENK had abundant mRNA for the D1a receptor. A subset of these cells (~50%) coexpressed D3 or D4 receptor mRNA. Neurons expressing detectable levels of ENK but not SP had abundant mRNA for D2 receptor isoforms (short and long). A subset (10-25%) of these neurons coexpressed D1a or D1b mRNAs. Neurons coexpressing ENK and SP mRNAs consistently coexpressed D1a and D2 mRNAs in relatively high abundance. Functional analysis of neurons expressing lower abundance mRNAs revealed clear physiological consequences that could be attributed to these receptors. These results suggest that, although colocalization of D1a and D2 receptors is limited, functional D1 and D2 class receptors are colocalized in nearly one-half of all medium spiny projection neurons.
Key words: medium spiny neurons; single-cell PCR; voltage clamp; RT-PCR; mRNA; Ca2+ channels; neuromodulation
This article has been cited by other articles:
F.-W. Zhou, Y. Jin, S. G. Matta, M. Xu, and F.-M. Zhou
An Ultra-Short Dopamine Pathway Regulates Basal Ganglia Output
J. Neurosci., August 19, 2009; 29(33): 10424 - 10435.
[Abstract] [Full Text] [PDF]
A. V. Cruz, N. Mallet, P. J. Magill, P. Brown, and B. B. Averbeck
Effects of Dopamine Depletion on Network Entropy in the External Globus Pallidus
J Neurophysiol, August 1, 2009; 102(2): 1092 - 1102.
[Abstract] [Full Text] [PDF]
F. Tecuapetla, T. Koos, J. M. Tepper, N. Kabbani, and M. F. Yeckel
Differential Dopaminergic Modulation of Neostriatal Synaptic Connections of Striatopallidal Axon Collaterals
J. Neurosci., July 15, 2009; 29(28): 8977 - 8990.
[Abstract] [Full Text] [PDF]
C. A. Deister, C. S. Chan, D. J. Surmeier, and C. J. Wilson
Calcium-Activated SK Channels Influence Voltage-Gated Ion Channels to Determine the Precision of Firing in Globus Pallidus Neurons
J. Neurosci., July 1, 2009; 29(26): 8452 - 8461.
[Abstract] [Full Text] [PDF]
B. H. Meurers, G. Dziewczapolski, T. Shi, A. Bittner, F. Kamme, and C. W. Shults
Dopamine Depletion Induces Distinct Compensatory Gene Expression Changes in DARPP-32 Signal Transduction Cascades of Striatonigral and Striatopallidal Neurons
J. Neurosci., May 27, 2009; 29(21): 6828 - 6839.
[Abstract] [Full Text] [PDF]
I. Boileau, M. Guttman, P. Rusjan, J. R. Adams, S. Houle, J. Tong, O. Hornykiewicz, Y. Furukawa, A. A. Wilson, S. Kapur, et al.
Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease
Brain, May 1, 2009; 132(5): 1366 - 1375.
[Abstract] [Full Text] [PDF]
S. Chung, F. W. Hopf, H. Nagasaki, C.-Y. Li, J. D. Belluzzi, A. Bonci, and O. Civelli
The melanin-concentrating hormone system modulates cocaine reward
PNAS, April 21, 2009; 106(16): 6772 - 6777.
[Abstract] [Full Text] [PDF]
J. Zhang, T.-X. Xu, P. J. Hallett, M. Watanabe, S. G. N. Grant, O. Isacson, and W.-D. Yao
PSD-95 Uncouples Dopamine-Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex
J. Neurosci., March 4, 2009; 29(9): 2948 - 2960.
[Abstract] [Full Text] [PDF]
T. S. Gertler, C. S. Chan, and D. J. Surmeier
Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons
J. Neurosci., October 22, 2008; 28(43): 10814 - 10824.
[Abstract] [Full Text] [PDF]
D. Marcellino, S. Ferre, V. Casado, A. Cortes, B. Le Foll, C. Mazzola, F. Drago, O. Saur, H. Stark, A. Soriano, et al.
Identification of Dopamine D1-D3 Receptor Heteromers: INDICATIONS FOR A ROLE OF SYNERGISTIC D1-D3 RECEPTOR INTERACTIONS IN THE STRIATUM
J. Biol. Chem., September 19, 2008; 283(38): 26016 - 26025.
[Abstract] [Full Text] [PDF]
L. Liang, M. R. DeLong, and S. M. Papa
Inversion of Dopamine Responses in Striatal Medium Spiny Neurons and Involuntary Movements
J. Neurosci., July 23, 2008; 28(30): 7537 - 7547.
[Abstract] [Full Text] [PDF]
C. Fiorentini, C. Busi, E. Gorruso, C. Gotti, P. Spano, and C. Missale
Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization
Mol. Pharmacol., July 1, 2008; 74(1): 59 - 69.
[Abstract] [Full Text] [PDF]
J. Ding, J. D. Peterson, and D. J. Surmeier
Corticostriatal and Thalamostriatal Synapses Have Distinctive Properties
J. Neurosci., June 18, 2008; 28(25): 6483 - 6492.
[Abstract] [Full Text] [PDF]
J. Bertran-Gonzalez, C. Bosch, M. Maroteaux, M. Matamales, D. Herve, E. Valjent, and J.-A. Girault
Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol
J. Neurosci., May 28, 2008; 28(22): 5671 - 5685.
[Abstract] [Full Text] [PDF]
S. Ramanathan, T. Tkatch, J. F. Atherton, C. J. Wilson, and M. D. Bevan
D2-Like Dopamine Receptors Modulate SKCa Channel Function in Subthalamic Nucleus Neurons Through Inhibition of Cav2.2 Channels
J Neurophysiol, February 1, 2008; 99(2): 442 - 459.
[Abstract] [Full Text] [PDF]
F.-W. Zhou, S. G. Matta, and F.-M. Zhou
Constitutively Active TRPC3 Channels Regulate Basal Ganglia Output Neurons
J. Neurosci., January 9, 2008; 28(2): 473 - 482.
[Abstract] [Full Text] [PDF]
J. T. Moyer, J. A. Wolf, and L. H. Finkel
Effects of Dopaminergic Modulation on the Integrative Properties of the Ventral Striatal Medium Spiny Neuron
J Neurophysiol, December 1, 2007; 98(6): 3731 - 3748.
[Abstract] [Full Text] [PDF]
T.-S. Tang, X. Chen, J. Liu, and I. Bezprozvanny
Dopaminergic Signaling and Striatal Neurodegeneration in Huntington's Disease
J. Neurosci., July 25, 2007; 27(30): 7899 - 7910.
[Abstract] [Full Text] [PDF]
F. Tecuapetla, L. Carrillo-Reid, J. Bargas, and E. Galarraga
Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses
PNAS, June 12, 2007; 104(24): 10258 - 10263.
[Abstract] [Full Text] [PDF]
J. E. Crandall, D. M. McCarthy, K. Y. Araki, J. R. Sims, J.-Q. Ren, and P. G. Bhide
Dopamine Receptor Activation Modulates GABA Neuron Migration from the Basal Forebrain to the Cerebral Cortex
J. Neurosci., April 4, 2007; 27(14): 3813 - 3822.
[Abstract] [Full Text] [PDF]
A. Bogush, S. Pedrini, J. Pelta-Heller, T. Chan, Q. Yang, Z. Mao, E. Sluzas, T. Gieringer, and M. E. Ehrlich
AKT and CDK5/p35 Mediate Brain-derived Neurotrophic Factor Induction of DARPP-32 in Medium Size Spiny Neurons in Vitro
J. Biol. Chem., March 9, 2007; 282(10): 7352 - 7359.
[Abstract] [Full Text] [PDF]
I. Gantois, K. Fang, L. Jiang, D. Babovic, A. J. Lawrence, V. Ferreri, Y. Teper, B. Jupp, J. Ziebell, C. M. Morganti-Kossmann, et al.
Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior
PNAS, March 6, 2007; 104(10): 4182 - 4187.
[Abstract] [Full Text] [PDF]
M. D. Humphries, R. D. Stewart, and K. N. Gurney
A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia
J. Neurosci., December 13, 2006; 26(50): 12921 - 12942.
[Abstract] [Full Text] [PDF]
A. Nadjar, J. M. Brotchie, C. Guigoni, Q. Li, S.-B. Zhou, G.-J. Wang, P. Ravenscroft, F. Georges, A. R. Crossman, and E. Bezard
Phenotype of Striatofugal Medium Spiny Neurons in Parkinsonian and Dyskinetic Nonhuman Primates: A Call for a Reappraisal of the Functional Organization of the Basal Ganglia.
J. Neurosci., August 23, 2006; 26(34): 8653 - 8661.
[Abstract] [Full Text] [PDF]
K. Nakamura and O. Hikosaka
Role of dopamine in the primate caudate nucleus in reward modulation of saccades.
J. Neurosci., May 17, 2006; 26(20): 5360 - 5369.
[Abstract] [Full Text] [PDF]
K.-W. Lee, Y. Kim, A. M. Kim, K. Helmin, A. C. Nairn, and P. Greengard
Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens
PNAS, February 28, 2006; 103(9): 3399 - 3404.
[Abstract] [Full Text] [PDF]
O. Hikosaka, K. Nakamura, and H. Nakahara
Basal Ganglia Orient Eyes to Reward
J Neurophysiol, February 1, 2006; 95(2): 567 - 584.
[Abstract] [Full Text] [PDF]
H. Salgado, F. Tecuapetla, T. Perez-Rosello, A. Perez-Burgos, E. Perez-Garci, E. Galarraga, and J. Bargas
A Reconfiguration of CaV2 Ca2+ Channel Current and Its Dopaminergic D2 Modulation in Developing Neostriatal Neurons
J Neurophysiol, December 1, 2005; 94(6): 3771 - 3787.
[Abstract] [Full Text] [PDF]
M. Levesque and A. Parent
The striatofugal fiber system in primates: A reevaluation of its organization based on single-axon tracing studies
PNAS, August 16, 2005; 102(33): 11888 - 11893.
[Abstract] [Full Text] [PDF]
W. Shen, S. E. Hamilton, N. M. Nathanson, and D. J. Surmeier
Cholinergic Suppression of KCNQ Channel Currents Enhances Excitability of Striatal Medium Spiny Neurons
J. Neurosci., August 10, 2005; 25(32): 7449 - 7458.
[Abstract] [Full Text] [PDF]
A. Wagatsuma, H. Sadamoto, T. Kitahashi, K. Lukowiak, A. Urano, and E. Ito
Determination of the exact copy numbers of particular mRNAs in a single cell by quantitative real-time RT-PCR
J. Exp. Biol., June 15, 2005; 208(12): 2389 - 2398.
[Abstract] [Full Text] [PDF]
A. Kovoor, P. Seyffarth, J. Ebert, S. Barghshoon, C.-K. Chen, S. Schwarz, J. D. Axelrod, B. N. R. Cheyette, M. I. Simon, H. A. Lester, et al.
D2 Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways
J. Neurosci., February 23, 2005; 25(8): 2157 - 2165.
[Abstract] [Full Text] [PDF]
P. A. Olson, T. Tkatch, S. Hernandez-Lopez, S. Ulrich, E. Ilijic, E. Mugnaini, H. Zhang, I. Bezprozvanny, and D. J. Surmeier
G-Protein-Coupled Receptor Modulation of Striatal CaV1.3 L-Type Ca2+ Channels Is Dependent on a Shank-Binding Domain
J. Neurosci., February 2, 2005; 25(5): 1050 - 1062.
[Abstract] [Full Text] [PDF]
B. Zucker, R. Luthi-Carter, J. A. Kama, A. W. Dunah, E. A. Stern, J. H. Fox, D. G. Standaert, A. B. Young, and S. J. Augood
Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1
Hum. Mol. Genet., January 15, 2005; 14(2): 179 - 189.
[Abstract] [Full Text] [PDF]
M. Toledo-Rodriguez, B. Blumenfeld, C. Wu, J. Luo, B. Attali, P. Goodman, and H. Markram
Correlation Maps Allow Neuronal Electrical Properties to be Predicted from Single-cell Gene Expression Profiles in Rat Neocortex
Cereb Cortex, December 1, 2004; 14(12): 1310 - 1327.
[Abstract] [Full Text] [PDF]
C. S. Chan, R. Shigemoto, J. N. Mercer, and D. J. Surmeier
HCN2 and HCN1 Channels Govern the Regularity of Autonomous Pacemaking and Synaptic Resetting in Globus Pallidus Neurons
J. Neurosci., November 3, 2004; 24(44): 9921 - 9932.
[Abstract] [Full Text] [PDF]
S. V. Rakhilin, P. A. Olson, A. Nishi, N. N. Starkova, A. A. Fienberg, A. C. Nairn, D. J. Surmeier, and P. Greengard
A Network of Control Mediated by Regulator of Calcium/Calmodulin-Dependent Signaling
Science, October 22, 2004; 306(5696): 698 - 701.
[Abstract] [Full Text] [PDF]
A. Pollack
Coactivation of D1 and D2 Dopamine Receptors: In Marriage, a Case of His, Hers, and Theirs
Sci. Signal., October 19, 2004; 2004(255): pe50 - pe50.
[Abstract] [Full Text] [PDF]
T.-S. Tang and I. Bezprozvanny
Dopamine Receptor-mediated Ca2+ Signaling in Striatal Medium Spiny Neurons
J. Biol. Chem., October 1, 2004; 279(40): 42082 - 42094.
[Abstract] [Full Text] [PDF]
W. Lei, Y. Jiao, N. Del Mar, and A. Reiner
Evidence for Differential Cortical Input to Direct Pathway versus Indirect Pathway Striatal Projection Neurons in Rats
J. Neurosci., September 22, 2004; 24(38): 8289 - 8299.
[Abstract] [Full Text] [PDF]
S. P. Lee, C. H. So, A. J. Rashid, G. Varghese, R. Cheng, A. J. Lanca, B. F. O'Dowd, and S. R. George
Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal
J. Biol. Chem., August 20, 2004; 279(34): 35671 - 35678.
[Abstract] [Full Text] [PDF]
L. Zhang, D. Lou, H. Jiao, D. Zhang, X. Wang, Y. Xia, J. Zhang, and M. Xu
Cocaine-Induced Intracellular Signaling and Gene Expression Are Oppositely Regulated by the Dopamine D1 and D3 Receptors
J. Neurosci., March 31, 2004; 24(13): 3344 - 3354.
[Abstract] [Full Text] [PDF]
W. Shen, S. Hernandez-Lopez, T. Tkatch, J. E. Held, and D. J. Surmeier
Kv1.2-Containing K+ Channels Regulate Subthreshold Excitability of Striatal Medium Spiny Neurons
J Neurophysiol, March 1, 2004; 91(3): 1337 - 1349.
[Abstract] [Full Text] [PDF]
R.-M. Shin, M. Masuda, M. Miura, H. Sano, T. Shirasawa, W.-J. Song, K. Kobayashi, and T. Aosaki
Dopamine D4 Receptor-Induced Postsynaptic Inhibition of GABAergic Currents in Mouse Globus Pallidus Neurons
J. Neurosci., December 17, 2003; 23(37): 11662 - 11672.
[Abstract] [Full Text] [PDF]
H. Sano, Y. Yasoshima, N. Matsushita, T. Kaneko, K. Kohno, I. Pastan, and K. Kobayashi
Conditional Ablation of Striatal Neuronal Types Containing Dopamine D2 Receptor Disturbs Coordination of Basal Ganglia Function
J. Neurosci., October 8, 2003; 23(27): 9078 - 9088.
[Abstract] [Full Text] [PDF]
D. Centonze, C. Grande, E. Saulle, A. B. Martin, P. Gubellini, N. Pavon, A. Pisani, G. Bernardi, R. Moratalla, and P. Calabresi
Distinct Roles of D1 and D5 Dopamine Receptors in Motor Activity and Striatal Synaptic Plasticity
J. Neurosci., September 17, 2003; 23(24): 8506 - 8512.
[Abstract] [Full Text] [PDF]
A. J. Gruber, S. A. Solla, D. J. Surmeier, and J. C. Houk
Modulation of Striatal Single Units by Expected Reward: A Spiny Neuron Model Displaying Dopamine-Induced Bistability
J Neurophysiol, August 1, 2003; 90(2): 1095 - 1114.
[Abstract] [Full Text] [PDF]
D. Centonze, C. Grande, A. Usiello, P. Gubellini, E. Erbs, A. B. Martin, A. Pisani, N. Tognazzi, G. Bernardi, R. Moratalla, et al.
Receptor Subtypes Involved in the Presynaptic and Postsynaptic Actions of Dopamine on Striatal Interneurons
J. Neurosci., July 16, 2003; 23(15): 6245 - 6254.
[Abstract] [Full Text] [PDF]
S. Hattori, F. Murakami, and W.-J. Song
Quantitative Relationship Between Kv4.2 mRNA and A-Type K+ Current in Rat Striatal Cholinergic Interneurons During Development
J Neurophysiol, July 1, 2003; 90(1): 175 - 183.
[Abstract] [Full Text] [PDF]
S. Di, R. Malcher-Lopes, K. Cs. Halmos, and J. G. Tasker
Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism
J. Neurosci., June 15, 2003; 23(12): 4850 - 4857.
[Abstract] [Full Text] [PDF]
M. van den Top, M. F Nolan, K. Lee, P. J Richardson, R. M Buijs, C. H Davies, and D. Spanswick
Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones
J. Physiol., June 15, 2003; 549(3): 809 - 821.
[Abstract] [Full Text] [PDF]
J. H. Jhamandas, K. H. Harris, C. Cho, W. Fu, and D. MacTavish
Human Amylin Actions on Rat Cholinergic Basal Forebrain Neurons: Antagonism of Beta-Amyloid Effects
J Neurophysiol, June 1, 2003; 89(6): 2923 - 2930.
[Abstract] [Full Text] [PDF]
C. Fiorentini, F. Gardoni, P. Spano, M. Di Luca, and C. Missale
Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors
J. Biol. Chem., May 23, 2003; 278(22): 20196 - 20202.
[Abstract] [Full Text] [PDF]
A. Nishi, F. Liu, S. Matsuyama, M. Hamada, H. Higashi, A. C. Nairn, and P. Greengard
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling
PNAS, February 4, 2003; 100(3): 1322 - 1327.
[Abstract] [Full Text] [PDF]
T.-S. Tang, H. Tu, Z. Wang, and I. Bezprozvanny
Modulation of Type 1 Inositol (1,4,5)-Trisphosphate Receptor Function by Protein Kinase A and Protein Phosphatase 1alpha
J. Neurosci., January 15, 2003; 23(2): 403 - 415.
[Abstract] [Full Text] [PDF]
J. Flores-Hernandez, C. Cepeda, E. Hernandez-Echeagaray, C. R. Calvert, E. S. Jokel, A. A. Fienberg, P. Greengard, and M. S. Levine
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
J Neurophysiol, December 1, 2002; 88(6): 3010 - 3020.
[Abstract] [Full Text] [PDF]
J. H. Chin, K. Harris, D. MacTavish, and J. H. Jhamandas
Nociceptin/Orphanin FQ Modulation of Ionic Conductances in Rat Basal Forebrain Neurons
J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 188 - 195.
[Abstract] [Full Text] [PDF]
K.-W. Lee, J.-H. Hong, I. Y. Choi, Y. Che, J.-K. Lee, S.-D. Yang, C.-W. Song, H. S. Kang, J.-H. Lee, J. S. Noh, et al.
Impaired D2 Dopamine Receptor Function in Mice Lacking Type 5 Adenylyl Cyclase
J. Neurosci., September 15, 2002; 22(18): 7931 - 7940.
[Abstract] [Full Text] [PDF]
L. Ding and D. J. Perkel
Dopamine Modulates Excitability of Spiny Neurons in the Avian Basal Ganglia
J. Neurosci., June 15, 2002; 22(12): 5210 - 5218.
[Abstract] [Full Text] [PDF]
M. Sato and O. Hikosaka
Role of Primate Substantia Nigra Pars Reticulata in Reward-Oriented Saccadic Eye Movement
J. Neurosci., March 15, 2002; 22(6): 2363 - 2373.
[Abstract] [Full Text] [PDF]
S. Yasumoto, E. Tanaka, G. Hattori, H. Maeda, and H. Higashi
Direct and Indirect Actions of Dopamine on the Membrane Potential in Medium Spiny Neurons of the Mouse Neostriatum
J Neurophysiol, March 1, 2002; 87(3): 1234 - 1243.
[Abstract] [Full Text] [PDF]
B. L. Waszczak, L. P. Martin, H. E. Finlay, N. Zahr, and J. R. Stellar
Effects of Individual and Concurrent Stimulation of Striatal D1 and D2 Dopamine Receptors on Electrophysiological and Behavioral Output from Rat Basal Ganglia
J. Pharmacol. Exp. Ther., March 1, 2002; 300(3): 850 - 861.
[Abstract] [Full Text] [PDF]
J. H. Jhamandas, K. H. Harris, D. MacTavish, and B. S. Jassar
Novel Excitatory Actions of Galanin on Rat Cholinergic Basal Forebrain Neurons: Implications for Its Role in Alzheimer's Disease
J Neurophysiol, February 1, 2002; 87(2): 696 - 704.
[Abstract] [Full Text] [PDF]
Q. Wang, J. P. Jolly, J. D. Surmeier, B. M. Mullah, M. S. Lidow, C. M. Bergson, and J. D. Robishaw
Differential Dependence of the D1 and D5 Dopamine Receptors on the G Protein gamma 7 Subunit for Activation of Adenylylcyclase
J. Biol. Chem., October 12, 2001; 276(42): 39386 - 39393.
[Abstract] [Full Text] [PDF]
J. H. Jhamandas, C. Cho, B. Jassar, K. Harris, D. MacTavish, and J. Easaw
Cellular Mechanisms for Amyloid {beta}-Protein Activation of Rat Cholinergic Basal Forebrain Neurons
J Neurophysiol, September 1, 2001; 86(3): 1312 - 1320.
[Abstract] [Full Text] [PDF]
J. Feng, X. Cai, J. Zhao, and Z. Yan
Serotonin Receptors Modulate GABAA Receptor Channels through Activation of Anchored Protein Kinase C in Prefrontal Cortical Neurons
J. Neurosci., September 1, 2001; 21(17): 6502 - 6511.
[Abstract] [Full Text] [PDF]
P. Calabresi, P. Gubellini, B. Picconi, D. Centonze, A. Pisani, P. Bonsi, P. Greengard, R. A. Hipskind, E. Borrelli, and G. Bernardi
Inhibition of Mitochondrial Complex II Induces a Long-Term Potentiation of NMDA-Mediated Synaptic Excitation in the Striatum Requiring Endogenous Dopamine
J. Neurosci., July 15, 2001; 21(14): 5110 - 5120.
[Abstract] [Full Text] [PDF]
D. Herve, C. Le Moine, J.-C. Corvol, L. Belluscio, C. Ledent, A. A. Fienberg, M. Jaber, J.-M. Studler, and J.-A. Girault
G{alpha}olf Levels Are Regulated by Receptor Usage and Control Dopamine and Adenosine Action in the Striatum
J. Neurosci., June 15, 2001; 21(12): 4390 - 4399.
[Abstract] [Full Text] [PDF]
T. Boraud, E. Bezard, B. Bioulac, and C. E. Gross
Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey
Brain, March 1, 2001; 124(3): 546 - 557.
[Abstract] [Full Text] [PDF]
J. T. Williams, M. J. Christie, and O. Manzoni
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Physiol Rev, January 1, 2001; 81(1): 299 - 343.
[Abstract] [Full Text] [PDF]
S. Hernandez-Lopez, T. Tkatch, E. Perez-Garci, E. Galarraga, J. Bargas, H. Hamm, and D. J. Surmeier
D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLC{beta}1-IP3-Calcineurin-Signaling Cascade
J. Neurosci., December 15, 2000; 20(24): 8987 - 8995.
[Abstract] [Full Text] [PDF]
R. R. Metzger, H. M. Haughey, D. G. Wilkins, J. W. Gibb, G. R. Hanson, and A. E. Fleckenstein
Methamphetamine-Induced Rapid Decrease in Dopamine Transporter Function: Role of Dopamine and Hyperthermia
J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 1077 - 1085.
[Abstract] [Full Text]
P. Calabresi, P. Gubellini, D. Centonze, B. Picconi, G. Bernardi, K. Chergui, P. Svenningsson, A. A. Fienberg, and P. Greengard
Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity
J. Neurosci., November 15, 2000; 20(22): 8443 - 8451.
[Abstract] [Full Text] [PDF]
R. C. Foehring, P. G. Mermelstein, W.-J. Song, S. Ulrich, and D. J. Surmeier
Unique Properties of R-Type Calcium Currents in Neocortical and Neostriatal Neurons
J Neurophysiol, November 1, 2000; 84(5): 2225 - 2236.
[Abstract] [Full Text] [PDF]
G. J. LaHoste, B. L. Henry, and J. F. Marshall
Dopamine D1 Receptors Synergize with D2, But Not D3 or D4, Receptors in the Striatum without the Involvement of Action Potentials
J. Neurosci., September 1, 2000; 20(17): 6666 - 6671.
[Abstract] [Full Text] [PDF]
K. J. Black, T. Hershey, M. H. Gado, and J. S. Perlmutter
Dopamine D1 Agonist Activates Temporal Lobe Structures in Primates
J Neurophysiol, July 1, 2000; 84(1): 549 - 557.
[Abstract] [Full Text] [PDF]
O. Hikosaka, Y. Takikawa, and R. Kawagoe
Role of the Basal Ganglia in the Control of Purposive Saccadic Eye Movements
Physiol Rev, July 1, 2000; 80(3): 953 - 978.
[Abstract] [Full Text] [PDF]
J. Flores-Hernandez, S. Hernandez, G. L. Snyder, Z. Yan, A. A. Fienberg, S. J. Moss, P. Greengard, and D. J. Surmeier
D1 Dopamine Receptor Activation Reduces GABAA Receptor Currents in Neostriatal Neurons Through a PKA/DARPP-32/PP1 Signaling Cascade
J Neurophysiol, May 1, 2000; 83(5): 2996 - 3004.
[Abstract] [Full Text] [PDF]
T. Tkatch, G. Baranauskas, and D. J. Surmeier
Kv4.2 mRNA Abundance and A-Type K+ Current Amplitude Are Linearly Related in Basal Ganglia and Basal Forebrain Neurons
J. Neurosci., January 15, 2000; 20(2): 579 - 588.
[Abstract] [Full Text] [PDF]
W.-J. Song, T. Tkatch, and D. J. Surmeier
Adenosine Receptor Expression and Modulation of Ca2+ Channels in Rat Striatal Cholinergic Interneurons
J Neurophysiol, January 1, 2000; 83(1): 322 - 332.
[Abstract] [Full Text] [PDF]
M.-Y. Jung and C. Schmauss
Decreased c-fos Responses to Dopamine D1 Receptor Agonist Stimulation in Mice Deficient for D3 Receptors
J. Biol. Chem., October 8, 1999; 274(41): 29406 - 29412.
[Abstract] [Full Text] [PDF]
M. Roudbaraki, A. Lorsignol, L. Langouche, G. Callewaert, H. Vankelecom, and C. Denef
Target Cells of {gamma}3-Melanocyte-Stimulating Hormone Detected through Intracellular Ca2+ Responses in Immature Rat Pituitary Constitute a Fraction of All Main Pituitary Cell Types, but Mostly Express Multiple Hormone Phenotypes at the Messenger Ribonucleic Acid Level. Refractoriness to Melanocortin-3 Receptor Blockade in the Lacto-Somatotroph Lineage
Endocrinology, October 1, 1999; 140(10): 4874 - 4885.
[Abstract] [Full Text]
P. G. Mermelstein, R. C. Foehring, T. Tkatch, W.-J. Song, G. Baranauskas, and D. J. Surmeier
Properties of Q-Type Calcium Channels in Neostriatal and Cortical Neurons are Correlated with beta Subunit Expression
J. Neurosci., September 1, 1999; 19(17): 7268 - 7277.
[Abstract] [Full Text] [PDF]
G. Torres and J. M. Horowitz
Drugs of Abuse and Brain Gene Expression
Psychosom Med, September 1, 1999; 61(5): 630 - 650.
[Abstract] [Full Text] [PDF]
E. V. Gurevich, J. W. Himes, and J. N. Joyce
Developmental Regulation of Expression of the D3 Dopamine Receptor in Rat Nucleus Accumbens and Islands of Calleja
J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 587 - 598.
[Abstract] [Full Text]
N. S. Magoski and A. G. M. Bulloch
Dopamine Activates Two Different Receptors to Produce Variability in Sign at an Identified Synapse
J Neurophysiol, March 1, 1999; 81(3): 1330 - 1340.
[Abstract] [Full Text] [PDF]
R. Grondin, V. D. Doan, L. Gregoire, and P. J. Bedard
D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys
Neurology, March 1, 1999; 52(4): 771 - 771.
[Abstract] [Full Text] [PDF]
F. R. Fusco, Q. Chen, W. J. Lamoreaux, G. Figueredo-Cardenas, Y. Jiao, J. A. Coffman, D. J. Surmeier, M. G. Honig, L. R. Carlock, and A. Reiner
Cellular Localization of Huntingtin in Striatal and Cortical Neurons in Rats: Lack of Correlation with Neuronal Vulnerability in Huntington's Disease
J. Neurosci., February 15, 1999; 19(4): 1189 - 1202.
[Abstract] [Full Text] [PDF]
A. E. Stewart, Z. Yan, D. J. Surmeier, and R. C. Foehring
Muscarine Modulates Ca2+ Channel Currents in Rat Sensorimotor Pyramidal Cells Via Two Distinct Pathways
J Neurophysiol, January 1, 1999; 81(1): 72 - 84.
[Abstract] [Full Text] [PDF]
E. C. Muly III, K. Szigeti, and P. S. Goldman-Rakic
D1 Receptor in Interneurons of Macaque Prefrontal Cortex: Distribution and Subcellular Localization
J. Neurosci., December 15, 1998; 18(24): 10553 - 10565.
[Abstract] [Full Text] [PDF]
J. Drago, P. Padungchaichot, J. Y. F. Wong, A. J. Lawrence, J. F. McManus, S. H. Sumarsono, A. L. Natoli, M. Lakso, N. Wreford, H. Westphal, et al.
Targeted Expression of a Toxin Gene to D1 Dopamine Receptor Neurons by Cre-Mediated Site-Specific Recombination
J. Neurosci., December 1, 1998; 18(23): 9845 - 9857.
[Abstract] [Full Text] [PDF]
B. L. Waszczak, L. P. Martin, G. J. Greif, and J. E. Freedman
Expression of a dopamine D2 receptor-activated K+ channel on identified striatopallidal and striatonigral neurons
PNAS, September 15, 1998; 95(19): 11440 - 11444.
[Abstract] [Full Text] [PDF]
P. G. Mermelstein, W.-J. Song, T. Tkatch, Z. Yan, and D. J. Surmeier
Inwardly Rectifying Potassium (IRK) Currents Are Correlated with IRK Subunit Expression in Rat Nucleus Accumbens Medium Spiny Neurons
J. Neurosci., September 1, 1998; 18(17): 6650 - 6661.
[Abstract] [Full Text] [PDF]
E. N. Pothos, S. Przedborski, V. Davila, Y. Schmitz, and D. Sulzer
D2-Like Dopamine Autoreceptor Activation Reduces Quantal Size in PC12 Cells
J. Neurosci., August 1, 1998; 18(15): 5575 - 5585.
[Abstract] [Full Text] [PDF]
E. P. Brandon, S. F. Logue, M. R. Adams, M. Qi, S. P. Sullivan, A. M. Matsumoto, D. M. Dorsa, J. M. Wehner, G. S. McKnight, and R. L. Idzerda
Defective Motor Behavior and Neural Gene Expression in RIIbeta -Protein Kinase A Mutant Mice
J. Neurosci., May 15, 1998; 18(10): 3639 - 3649.
[Abstract] [Full Text] [PDF]
W.-J. Song, T. Tkatch, G. Baranauskas, N. Ichinohe, S. T. Kitai, and D. J. Surmeier
Somatodendritic Depolarization-Activated Potassium Currents in Rat Neostriatal Cholinergic Interneurons Are Predominantly of the A Type and Attributable to Coexpression of Kv4.2 and Kv4.1 Subunits
J. Neurosci., May 1, 1998; 18(9): 3124 - 3137.
[Abstract] [Full Text] [PDF]
M. A. Kelly, M. Rubinstein, T. J. Phillips, C. N. Lessov, S. Burkhart-Kasch, G. Zhang, J. R. Bunzow, Y. Fang, G. A. Gerhardt, D. K. Grandy, et al.
Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations
J. Neurosci., May 1, 1998; 18(9): 3470 - 3479.
[Abstract] [Full Text] [PDF]
L. A. Gabel and E. S. Nisenbaum
Biophysical Characterization and Functional Consequences of a Slowly Inactivating Potassium Current in Neostriatal Neurons
J Neurophysiol, April 1, 1998; 79(4): 1989 - 2002.
[Abstract] [Full Text] [PDF]
P. J. Blanchet, S. Konitsiotis, and T. N. Chase
Motor Response to a Dopamine D3 Receptor Preferring Agonist Compared to Apomorphine in Levodopa-Primed 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Monkeys
J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 794 - 794.
[Abstract] [Full Text]
|
|
|
|
 |
|