WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (87)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sutula, T.
Right arrow Articles by McNamara, J. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sutula, T.
Right arrow Articles by McNamara, J. O.

 Previous Article

Volume 16, Number 22, Issue of November 15, 1996 pp. 7398-7406
Copyright ©1996 Society for Neuroscience

NMDA Receptor Dependence of Kindling and Mossy Fiber Sprouting: Evidence that the NMDA Receptor Regulates Patterning of Hippocampal Circuits in the Adult Brain

Received May 14, 1996; revised Aug. 30, 1996; accepted Sept. 4, 1996.

T. Sutula1, 2, J. Koch1, G. Golarai1, 2, Y. Watanabe3, 4, 5, and J. O. McNamara3, 4, 5

1 Departments of Neurology and Anatomy, and the 2 Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53292, and Departments of 3 Medicine (Neurology) and 4 Neurobiology and Pharmacology, and 5 the Epilepsy Research Laboratory, Veterans Affairs Medical Center, Duke University, Durham, North Carolina 27705

The NMDA receptor plays an important role in patterning neural connectivity in the developing brain. In the adult brain, repeated kindling stimulation of limbic pathways increases the NMDA-dependent component of synaptic transmission in granule cells of the dentate gyrus (DG) and also induces sprouting of the mossy fiber axons of granule cells that reorganizes synaptic connections in the DG. Because the NMDA antagonist MK801 impedes the progression of kindling, it was of interest to determine whether MK801 also modified mossy fiber sprouting. Low doses of MK801, which had no antiseizure effect, impaired the progression of kindling and development of mossy fiber sprouting during the initial and also more advanced stages of kindling. These observations demonstrate that the NMDA receptor is a component of a molecular pathway that influences the progression of kindling and mossy fiber sprouting and suggest that NMDA-dependent gene expression may play a role in the development of long-term structural and functional alterations induced by seizures in hippocampal circuitry. The NMDA receptor appears to play a continuing role in modifying the organization and patterns of connectivity in hippocampal circuits of the adult brain.

Key words: NMDA; kindling; sprouting; hippocampus; plasticity; receptors; MK801; dentate gyrus; seizures epilepsy




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. N. Rakhade, C. Zhou, P. K. Aujla, R. Fishman, N. J. Sucher, and F. E. Jensen
Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures
J. Neurosci., August 6, 2008; 28(32): 7979 - 7990.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q. Chen, S. He, X.-L. Hu, J. Yu, Y. Zhou, J. Zheng, S. Zhang, C. Zhang, W.-H. Duan, and Z.-Q. Xiong
Differential Roles of NR2A- and NR2B-Containing NMDA Receptors in Activity-Dependent Brain-Derived Neurotrophic Factor Gene Regulation and Limbic Epileptogenesis
J. Neurosci., January 17, 2007; 27(3): 542 - 552.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
J. O. McNamara, Y. Z. Huang, and A. S. Leonard
Molecular Signaling Mechanisms Underlying Epileptogenesis
Sci. Signal., October 10, 2006; 2006(356): re12 - re12.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. B. Bausch, S. He, Y. Petrova, X.-M. Wang, and J. O. McNamara
Plasticity of Both Excitatory and Inhibitory Synapses Is Associated With Seizures Induced by Removal of Chronic Blockade of Activity in Cultured Hippocampus
J Neurophysiol, October 1, 2006; 96(4): 2151 - 2167.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. S. Mangan and J. Kapur
Factors Underlying Bursting Behavior in a Network of Cultured Hippocampal Neurons Exposed to Zero Magnesium
J Neurophysiol, February 1, 2004; 91(2): 946 - 957.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
G. L. Holmes
Seizure-induced neuronal injury: Animal data
Neurology, November 12, 2002; 59(90095): S3 - 6.
[Abstract] [Full Text]

Home page
 NeurologyHome page
A. Pitkanen
Drug-mediated neuroprotection and antiepileptogenesis: Animal data
Neurology, November 12, 2002; 59(90095): S27 - 33.
[Abstract] [Full Text]

Home page
 Am. J. Neuroradiol.Home page
L. P. Mark, R. W. Prost, J. L. Ulmer, M. M. Smith, D. L. Daniels, J. M. Strottmann, W. D. Brown, and L. Hacein-Bey
Pictorial Review of Glutamate Excitotoxicity: Fundamental Concepts for Neuroimaging
AJNR Am. J. Neuroradiol., November 1, 2001; 22(10): 1813 - 1824.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Golarai, A. C. Greenwood, D. M. Feeney, and J. A. Connor
Physiological and Structural Evidence for Hippocampal Involvement in Persistent Seizure Susceptibility after Traumatic Brain Injury
J. Neurosci., November 1, 2001; 21(21): 8523 - 8537.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Behr, U. Heinemann, and I. Mody
Kindling Induces Transient NMDA Receptor-Mediated Facilitation of High-Frequency Input in the Rat Dentate Gyrus
J Neurophysiol, May 1, 2001; 85(5): 2195 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. R G Sanabria, H. Su, and Y. Yaari
Initiation of network bursts by Ca2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy
J. Physiol., April 1, 2001; 532(1): 205 - 216.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Lynch, U. Sayin, G. Golarai, and T. Sutula
NMDA Receptor-Dependent Plasticity of Granule Cell Spiking in the Dentate Gyrus of Normal and Epileptic Rats
J Neurophysiol, December 1, 2000; 84(6): 2868 - 2879.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. A. McKinney, A. Luthi, C. E. Bandtlow, B. H. Gahwiler, and S. M. Thompson
Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures
PNAS, September 28, 1999; 96(20): 11631 - 11636.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
U. Sayin, P. Rutecki, and T. Sutula
NMDA-Dependent Currents in Granule Cells of the Dentate Gyrus Contribute to Induction but Not Permanence of Kindling
J Neurophysiol, February 1, 1999; 81(2): 564 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Shoji, E. Tanaka, S. Yamamoto, H. Maeda, and H. Higashi
Mechanisms Underlying the Enhancement of Excitatory Synaptic Transmission in Basolateral Amygdala Neurons of the Kindling Rat
J Neurophysiol, August 1, 1998; 80(2): 638 - 646.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Behr, K. J. Lyson, and I. Mody
Enhanced Propagation of Epileptiform Activity Through the Kindled Dentate Gyrus
J Neurophysiol, April 1, 1998; 79(4): 1726 - 1732.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. M. Magarinos, J. M. G. Verdugo, and B. S. McEwen
Chronic stress alters synaptic terminal structure in hippocampus
PNAS, December 9, 1997; 94(25): 14002 - 14008.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-