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Next Article 
Volume 16, Number 23,
Issue of December 1, 1996
pp. 7407-7415
Copyright ©1996 Society for Neuroscience
Cloning and Characterization of Postsynaptic Density 93, a Nitric
Oxide Synthase Interacting Protein
Received July 8, 1996; revised Sept. 4, 1996; accepted Sept. 9, 1996.
Jay E. Brenman,
Karen S. Christopherson,
Sarah E. Craven,
Aaron W. McGee, and
David S. Bredt
Department of Physiology and Programs in Biomedical Sciences and
Neuroscience, University of California at San Francisco School of
Medicine, San Francisco, California 94143-0444
Nitric oxide (NO) formation in brain is regulated by the
calcium/calmodulin dependence of neuronal NO synthase (nNOS). Calcium influx through NMDA-type glutamate receptors is efficiently coupled to
nNOS activity, whereas many other intracellular calcium pathways are
poorly coupled. To elucidate possible mechanisms responsible for this
coupling, we performed yeast two-hybrid screening to identify proteins
that interact with nNOS. Two nNOS interacting proteins were identified:
the postsynaptic density proteins PSD-93 and PSD-95. Here, we report
the cloning and characterization of PSD-93. PSD-93 is expressed in
discrete neuronal populations as well as in specific non-neuronal
cells, and it exhibits complex molecular diversity attributable to
tissue-specific alternative splicing. PSD-93, like PSD-95, binds to
nNOS and to the NMDA receptor 2B. PSD-93, however, is unique among
PSD-95/SAP-90 family members in its expression in Purkinje neuron cell
bodies and dendrites. We also demonstrate that the PDZ domain at the N
terminus of nNOS is required, but it is not sufficient for interaction
with PSD-93/95. Given that PSD-93 and PSD-95 each contain multiple
potential binding sites for nNOS and the NMDA receptor, complexes
involving oligomers of PSD-93/95 may help account for the functional as
well as the physical coupling of nNOS to NMDA receptors.
Key words:
neuronal nitric oxide synthase;
NMDA receptor;
postsynaptic density;
Purkinje neurons;
glutamate;
calcium
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27(37):
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|
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|
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279(42):
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|
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|
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|
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|
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|
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|
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|
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|
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|
|
|
|
|
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278(38):
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|
|
|
|
|
|
|
Y.-X. Tao, G. Rumbaugh, G.-D. Wang, R. S. Petralia, C. Zhao, F. W. Kauer, F. Tao, M. Zhuo, R. J. Wenthold, S. N. Raja, et al.
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23(17):
6703 - 6712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Clinton, V. Haroutunian, K. L. Davis, and J. H. Meador-Woodruff
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160(6):
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Rumbaugh, G.-M. Sia, C. C. Garner, and R. L. Huganir
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J. Neurosci.,
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23(11):
4567 - 4576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. K. Seabold, A. Burette, I. A. Lim, R. J. Weinberg, and J. W. Hell
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J. Biol. Chem.,
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278(17):
15040 - 15048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Olsen and D. S. Bredt
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J. Biol. Chem.,
February 21, 2003;
278(9):
6873 - 6878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Sekerkova, P. A. Loomis, B. Changyaleket, L. Zheng, R. Eytan, B. Chen, E. Mugnaini, and J. R. Bartles
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J. Neurosci.,
February 15, 2003;
23(4):
1310 - 1319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. I. Nedvetsky, W. C. Sessa, and H. H. H. W. Schmidt
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December 24, 2002;
99(26):
16510 - 16512.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Wu, J. E. Nash, P. Zamorano, and C. C. Garner
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J. Biol. Chem.,
August 16, 2002;
277(34):
30928 - 30934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Chetkovich, R. C. Bunn, S.-H. Kuo, Y. Kawasaki, M. Kohwi, and D. S. Bredt
Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms
J. Neurosci.,
August 1, 2002;
22(15):
6415 - 6425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. A. Lim, D. D. Hall, and J. W. Hell
Selectivity and Promiscuity of the First and Second PDZ Domains of PSD-95 and Synapse-associated Protein 102
J. Biol. Chem.,
June 7, 2002;
277(24):
21697 - 21711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Inanobe, A. Fujita, M. Ito, H. Tomoike, K. Inageda, and Y. Kurachi
Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses
Am J Physiol Cell Physiol,
June 1, 2002;
282(6):
C1396 - C1403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Y. Hung and M. Sheng
PDZ Domains: Structural Modules for Protein Complex Assembly
J. Biol. Chem.,
February 15, 2002;
277(8):
5699 - 5702.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Miyagi, T. Yamashita, M. Fukaya, T. Sonoda, T. Okuno, K. Yamada, M. Watanabe, Y. Nagashima, I. Aoki, K. Okuda, et al.
Delphilin: a Novel PDZ and Formin Homology Domain-Containing Protein that Synaptically Colocalizes and Interacts with Glutamate Receptor delta 2 Subunit
J. Neurosci.,
February 1, 2002;
22(3):
803 - 814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Imamura, S. Maeda, T. Doi, and Y. Fujiyoshi
Ligand Binding of the Second PDZ Domain Regulates Clustering of PSD-95 with the Kv1.4 Potassium Channel
J. Biol. Chem.,
January 25, 2002;
277(5):
3640 - 3646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. McGee, J. R. Topinka, K. Hashimoto, R. S. Petralia, S. Kakizawa, F. Kauer, A. Aguilera-Moreno, R. J. Wenthold, M. Kano, and D. S. Bredt
PSD-93 Knock-Out Mice Reveal That Neuronal MAGUKs Are Not Required for Development or Function of Parallel Fiber Synapses in Cerebellum
J. Neurosci.,
May 1, 2001;
21(9):
3085 - 3091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hoshi and S. H Heinemann
Regulation of cell function by methionine oxidation and reduction
J. Physiol.,
February 15, 2001;
531(1):
1 - 11.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E.-D. El-Husseini, E. Schnell, D. M. Chetkovich, R. A. Nicoll, and D. S. Bredt
PSD-95 Involvement in Maturation of Excitatory Synapses
Science,
November 17, 2000;
290(5495):
1364 - 1368.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Maudsley, A. M. Zamah, N. Rahman, J. T. Blitzer, L. M. Luttrell, R. J. Lefkowitz, and R. A. Hall
Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity
Mol. Cell. Biol.,
November 15, 2000;
20(22):
8352 - 8363.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. S. Mandir, M. F. Poitras, A. R. Berliner, W. J. Herring, D. B. Guastella, A. Feldman, G. G. Poirier, Z.-Q. Wang, T. M. Dawson, and V. L. Dawson
NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase
J. Neurosci.,
November 1, 2000;
20(21):
8005 - 8011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Walikonis, O. N. Jensen, M. Mann, D. W. Provance Jr, J. A. Mercer, and M. B. Kennedy
Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry
J. Neurosci.,
June 1, 2000;
20(11):
4069 - 4080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shin, Y.-P. Hsueh, F.-C. Yang, E. Kim, and M. Sheng
An Intramolecular Interaction between Src Homology 3 Domain and Guanylate Kinase-Like Domain Required for Channel Clustering by Postsynaptic Density-95/SAP90
J. Neurosci.,
May 15, 2000;
20(10):
3580 - 3587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sans, R. S. Petralia, Y.-X. Wang, J. Blahos II, J. W. Hell, and R. J. Wenthold
A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses
J. Neurosci.,
February 1, 2000;
20(3):
1260 - 1271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. El-Husseini, S. E. Craven, D. M. Chetkovich, B. L. Firestein, E. Schnell, C. Aoki, and D. S. Bredt
Dual Palmitoylation of Psd-95 Mediates Its Vesiculotubular Sorting, Postsynaptic Targeting, and Ion Channel Clustering
J. Cell Biol.,
January 10, 2000;
148(1):
159 - 172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Claudepierre, C Dalloz, D Mornet, K Matsumura, J Sahel, and A Rendon
Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Muller glial cells
J. Cell Sci.,
January 10, 2000;
113(19):
3409 - 3417.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Sattler, Z. Xiong, W.-Y. Lu, J. F. MacDonald, and M. Tymianski
Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity
J. Neurosci.,
January 1, 2000;
20(1):
22 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Wang
Regulation of the ROMK channel: interaction of the ROMK with associate proteins
Am J Physiol Renal Physiol,
December 1, 1999;
277(6):
F826 - F831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Lim, S. Naisbitt, J. Yoon, J.-I. Hwang, P.-G. Suh, M. Sheng, and E. Kim
Characterization of the Shank Family of Synaptic Proteins. MULTIPLE GENES, ALTERNATIVE SPLICING, AND DIFFERENTIAL EXPRESSION IN BRAIN AND DEVELOPMENT
J. Biol. Chem.,
October 8, 1999;
274(41):
29510 - 29518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Boeckers, M. R. Kreutz, C. Winter, W. Zuschratter, K.-H. Smalla, L. Sanmarti-Vila, H. Wex, K. Langnaese, J. Bockmann, C. C. Garner, et al.
Proline-Rich Synapse-Associated Protein-1/Cortactin Binding Protein 1 (ProSAP1/CortBP1) Is a PDZ-Domain Protein Highly Enriched in the Postsynaptic Density
J. Neurosci.,
August 1, 1999;
19(15):
6506 - 6518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hayashi, M. Nishio, Y. Naito, H. Yokokura, Y. Nimura, H. Hidaka, and Y. Watanabe
Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases
J. Biol. Chem.,
July 16, 1999;
274(29):
20597 - 20602.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Sattler, Z. Xiong, W. Lu, M. Hafner, J. F. MacDonald, and M. Tymianski
Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein
Science,
June 11, 1999;
284(5421):
1845 - 1848.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. W. Roche, C. D. Ly, R. S. Petralia, Y.-X. Wang, A. W. McGee, D. S. Bredt, and R. J. Wenthold
Postsynaptic Density-93 Interacts with the delta 2 Glutamate Receptor Subunit at Parallel Fiber Synapses
J. Neurosci.,
May 15, 1999;
19(10):
3926 - 3934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Firestein and D. S. Bredt
Interaction of Neuronal Nitric-oxide Synthase and Phosphofructokinase-M
J. Biol. Chem.,
April 9, 1999;
274(15):
10545 - 10550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zhang, L. Vazquez, M. Apperson, and M. B. Kennedy
Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus
J. Neurosci.,
January 1, 1999;
19(1):
96 - 108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Veltkamp, F. Domoki, F. Bari, T. M. Louis, D. W. Busija, and F. M. Faraci
Inhibitors of Protein Synthesis Preserve the N-Methyl-D-Aspartate–Induced Cerebral Arteriolar Dilation After Ischemia in Piglets • Editorial Comment
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January 1, 1999;
30(1):
148 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Inglis, F. Furia, K. E. Zuckerman, S. M. Strittmatter, and R. G. Kalb
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J. Neurosci.,
December 15, 1998;
18(24):
10493 - 10501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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J. Biol. Chem.,
December 11, 1998;
273(50):
33472 - 33481.
[Abstract]
[Full Text]
[PDF]
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P. Koulen, E. L. Fletcher, S. E. Craven, D. S. Bredt, and H. Wassle
Immunocytochemical Localization of the Postsynaptic Density Protein PSD-95 in the Mammalian Retina
J. Neurosci.,
December 1, 1998;
18(23):
10136 - 10149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kimura, S. Uchiyama, H. E. Takahashi, and K. Shibuki
cAMP-Dependent Long-Term Potentiation of Nitric Oxide Release from Cerebellar Parallel Fibers in Rats
J. Neurosci.,
November 1, 1998;
18(21):
8551 - 8558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Brenman, J. R. Topinka, E. C. Cooper, A. W. McGee, J. Rosen, T. Milroy, H. J. Ralston, and D. S. Bredt
Localization of Postsynaptic Density-93 to Dendritic Microtubules and Interaction with Microtubule-Associated Protein 1A
J. Neurosci.,
November 1, 1998;
18(21):
8805 - 8813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bhardwaj, M. Sawada, E. D. London, R. C. Koehler, R. J. Traystman, J. R. Kirsch, and F. M. Faraci
Potent {varsigma}1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine Modulates Basal and N-Methyl-D-Aspartate–Evoked Nitric Oxide Production In Vivo • Editorial Comment
Stroke,
November 1, 1998;
29(11):
2404 - 2411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Gee, S. A. Sekely, C. Lombardo, A. Kurakin, S. C. Froehner, and B. K. Kay
Cyclic Peptides as Non-carboxyl-terminal Ligands of Syntrophin PDZ Domains
J. Biol. Chem.,
August 21, 1998;
273(34):
21980 - 21987.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Leonard, M. A. Davare, M. C. Horne, C. C. Garner, and J. W. Hell
SAP97 Is Associated with the alpha -Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit
J. Biol. Chem.,
July 31, 1998;
273(31):
19518 - 19524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Cohen, D. F. Wood, S. M. Marfatia, Z. Walther, A. H. Chishti, and J. M. Anderson
Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells
J. Cell Biol.,
July 13, 1998;
142(1):
129 - 138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Förstermann, J.-p. Boissel, and H. Kleinert
Expressional control of the `constitutive' isoforms of nitric oxide synthase (NOS I and NOS III)
FASEB J,
July 1, 1998;
12(10):
773 - 790.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Rao, E. Kim, M. Sheng, and A. M. Craig
Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture
J. Neurosci.,
February 15, 1998;
18(4):
1217 - 1229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Yang, C. Iadecola, and F. M. Faraci
Activation of Cerebellar Climbing Fibers Increases Cerebellar Blood Flow : Role of Glutamate Receptors, Nitric Oxide, and cGMP • Editorial Comment: Role of Glutamate Receptors, Nitric Oxide, and cGMP
Stroke,
February 1, 1998;
29(2):
499 - 508.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H Wu, S. Reuver, S Kuhlendahl, W. Chung, and C. Garner
Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane
J. Cell Sci.,
January 8, 1998;
111(16):
2365 - 2376.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. H. Gee, R. Madhavan, S. R. Levinson, J. H. Caldwell, R. Sealock, and S. C. Froehner
Interaction of Muscle and Brain Sodium Channels with Multiple Members of the Syntrophin Family of Dystrophin-Associated Proteins
J. Neurosci.,
January 1, 1998;
18(1):
128 - 137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Staudinger, J. Lu, and E. N. Olson
Specific Interaction of the PDZ Domain Protein PICK1 with the COOH Terminus of Protein Kinase C-alpha
J. Biol. Chem.,
December 19, 1997;
272(51):
32019 - 32024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Dobrosotskaya, R. K. Guy, and G. L. James
MAGI-1, a Membrane-associated Guanylate Kinase with a Unique Arrangement of Protein-Protein Interaction Domains
J. Biol. Chem.,
December 12, 1997;
272(50):
31589 - 31597.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Wu, C. Aoki, A. Elste, A. A. Rogalski-Wilk, and P. Siekevitz
The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxide
PNAS,
November 25, 1997;
94(24):
13273 - 13278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. J. Venema, H. Ju, R. Zou, and R. C. Venema
Interaction of Neuronal Nitric-oxide Synthase with Caveolin-3 in Skeletal Muscle. IDENTIFICATION OF A NOVEL CAVEOLIN SCAFFOLDING/INHIBITORY DOMAIN
J. Biol. Chem.,
November 7, 1997;
272(45):
28187 - 28190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Naisbitt, E. Kim, R. J. Weinberg, A. Rao, F.-C. Yang, A. M. Craig, and M. Sheng
Characterization of Guanylate Kinase-Associated Protein, a Postsynaptic Density Protein at Excitatory Synapses That Interacts Directly with Postsynaptic Density-95/Synapse-Associated Protein 90
J. Neurosci.,
August 1, 1997;
17(15):
5687 - 5696.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Komeima, Y. Hayashi, Y. Naito, and Y. Watanabe
Inhibition of Neuronal Nitric-oxide Synthase by Calcium/ Calmodulin-dependent Protein Kinase IIalpha through Ser847 Phosphorylation in NG108-15 Neuronal Cells
J. Biol. Chem.,
September 1, 2000;
275(36):
28139 - 28143.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. DeMarco and E. E. Strehler
Plasma Membrane Ca2+-ATPase Isoforms 2b and 4b Interact Promiscuously and Selectively with Members of the Membrane-associated Guanylate Kinase Family of PDZ (PSD95/Dlg/ZO-1) Domain-containing Proteins
J. Biol. Chem.,
June 8, 2001;
276(24):
21594 - 21600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Russwurm, N. Wittau, and D. Koesling
Guanylyl Cyclase/PSD-95 Interaction. TARGETING OF THE NITRIC OXIDE-SENSITIVE alpha 2beta 1 GUANYLYL CYCLASE TO SYNAPTIC MEMBRANES
J. Biol. Chem.,
November 21, 2001;
276(48):
44647 - 44652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Breton, T. Wiederhold, V. Marshansky, N. N. Nsumu, V. Ramesh, and D. Brown
The B1 Subunit of the H+ATPase Is a PDZ Domain-binding Protein. COLOCALIZATION WITH NHE-RF IN RENAL B-INTERCALATED CELLS
J. Biol. Chem.,
June 9, 2000;
275(24):
18219 - 18224.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. El-Husseini, J. R. Topinka, J. E. Lehrer-Graiwer, B. L. Firestein, S. E. Craven, C. Aoki, and D. S. Bredt
Ion Channel Clustering by Membrane-associated Guanylate Kinases. DIFFERENTIAL REGULATION BY N-TERMINAL LIPID AND METAL BINDING MOTIFS
J. Biol. Chem.,
July 28, 2000;
275(31):
23904 - 23910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
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