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Volume 16, Number 24,
Issue of December 15, 1996
pp. 8027-8040
Copyright ©1996 Society for Neuroscience
Dynamics of Mismatch Correction in the Hippocampal Ensemble Code
for Space: Interaction between Path Integration and Environmental
Cues
Received May 6, 1996; revised Aug. 22, 1996; accepted Sept. 20, 1996.
Katalin M. Gothard,
William E. Skaggs, and
Bruce L. McNaughton
Arizona Research Laboratories Division of Neural Systems, Memory
and Aging, University of Arizona, Tucson, Arizona 85724
Populations of hippocampal neurons were recorded simultaneously in
rats shuttling on a track between a fixed reward site at one end and a
movable reward site, mounted in a sliding box, at the opposite end.
While the rat ran toward the fixed site, the box was moved. The rat
returned to the box in its new position. On the initial part of all
journeys, cells fired at fixed distances from the origin, whereas on
the final part, cells fired at fixed distances from the destination.
Thus, on outward journeys from the box, with the box behind the rat,
the position representation must have been updated by path integration.
Farther along the journey, the place field map became aligned on the
basis of external stimuli. The spatial representation was quantified in
terms of population vectors. During shortened journeys, the vector
shifted from an alignment with the origin to an alignment with the
destination. The dynamics depended on the degree of mismatch with
respect to the full-length journey. For small mismatches, the vector
moved smoothly through intervening coordinates until the mismatch was corrected. For large mismatches, it jumped abruptly to the new coordinate. Thus, when mismatches occur, path integration and external
cues interact competitively to control place-cell firing.
When the same box was used in a different environment, it controlled
the alignment of a different set of place cells. These data suggest
that although map alignment can be controlled by landmarks, hippocampal
neurons do not explicitly represent objects or events.
Key words:
population vector;
cell ensemble;
computation;
path
integration;
place cells;
navigation
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|
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|
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|
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