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Journal of Neuroscience, Vol 16, 1072-1082, Copyright © 1996 by Society for Neuroscience
Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons
ET Kavalali and MR Plummer
Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855-1059, USA.
Neuronal voltage-gated calcium channels provide a pathway for calcium
influx that is required for processes ranging from intracellular signaling
to alterations in cellular excitability. In hippocampal neurons, we have
characterized a subtype of dihydropyridine-sensitive L- type calcium
channels (Lp channel) that shows multiple kinds of voltage- dependent
potentiation of its activity. One type of potentiation is elicited by
low-voltage stimuli (-10 mV) and can be seen in dual-pulse protocols in
which a transient hyperpolarization is interposed between conditioning and
test pulses. The second type of potentiation is elicited by much higher
voltages (+60 mV) and is selectively deactivated at hyperpolarized
voltages. We have compared these types of potentiation in the Lp channel,
the "standard" L-type channel, and the cardiac L-type channel. Our results
show that the high-voltage potentiation is common to all three channel
types. The low-voltage form of potentiation, however, is unique to the Lp
channel. Thus, the Lp channel shows two kinds of potentiation that differ
in their voltage dependence and rate of decay. Therefore, calcium channel
plasticity in the hippocampus has a variety of forms distinguished by their
stimulus requirements and duration.
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