 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 1230-1238, Copyright © 1996 by Society for Neuroscience
Cocaine alters cerebral metabolism within the ventral striatum and limbic cortex of monkeys
D Lyons, DP Friedman, MA Nader and LJ Porrino
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA.
The functional consequences of acute cocaine administration in nonhuman
primates were assessed using the quantitative 2-[14C]deoxyglucose method.
Local rates of cerebral metabolism were determined after an intravenous
infusion of 1.0 mg/kg cocaine or vehicle in six awake cynomolgus monkeys
(Macaca fascicularis) trained to sit calmly in a primate chair. Cocaine
administration decreased glucose utilization in a discrete set of
structures that included both cortical and subcortical portions of the
limbic system. Glucose metabolism in the core and shell of the nucleus
accumbens was decreased markedly, and smaller decrements were observed in
the caudate and anterior putamen. In addition, cocaine administration
produced significant decreases in limbic cortex. Metabolism was decreased
in orbitofrontal cortex (areas 11, 12o, 13, 13a, 13b), portions of the
gyrus rectus including area 25, entorhinal cortex, and parts of the
hippocampal formation. The cortical regions in which functional activity
was altered provide dense projections to the nucleus accumbens, and the
decreased activity in these projections may be responsible in part of the
large alterations in functional activity within the ventral striatum.
Decreased metabolism also was evident in the anterior nuclear group of the
thalamus, raphe nuclei, and locus ceruleus. The acute cerebral metabolic
effects of cocaine in the conscious macaque, therefore, were contained
primarily within a set of interconnected limbic regions, including ventral
prefrontal cortex, medial temporal regions, the ventral striatal complex,
and anterior thalamus. The decreased rates of glucose metabolism reported
here resemble decrements found using positron emission tomography in
humans. In the rat, by contrast, metabolic activity increased and changes
were focused in subcortical regions. The present results represent an
important expansion of the neural circuitry on which cocaine acts in the
monkey as compared with the rat, and this in turn implies that cocaine
affects a broader spectra of behaviors in primates than in rodents.
This article has been cited by other articles:
|
|
|
|
 
M. A Nader, P. W Czoty, R. W Gould, and N. V Riddick
Positron emission tomography imaging studies of dopamine receptors in primate models of addiction
Phil Trans R Soc B,
October 12, 2008;
363(1507):
3223 - 3232.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lu, Z.-X. Xi, L. Gitajn, W. Rea, Y. Yang, and E. A. Stein
Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI)
PNAS,
February 13, 2007;
104(7):
2489 - 2494.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Nader and P. W. Czoty
PET Imaging of Dopamine D2 Receptors in Monkey Models of Cocaine Abuse: Genetic Predisposition Versus Environmental Modulation
Am J Psychiatry,
August 1, 2005;
162(8):
1473 - 1482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Porrino, D. Lyons, H. R. Smith, J. B. Daunais, and M. A. Nader
Cocaine Self-Administration Produces a Progressive Involvement of Limbic, Association, and Sensorimotor Striatal Domains
J. Neurosci.,
April 7, 2004;
24(14):
3554 - 3562.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Porrino, D. Lyons, M. D. Miller, H. R. Smith, D. P. Friedman, J. B. Daunais, and M. A. Nader
Metabolic Mapping of the Effects of Cocaine during the Initial Phases of Self-Administration in the Nonhuman Primate
J. Neurosci.,
September 1, 2002;
22(17):
7687 - 7694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Bradberry
Acute and Chronic Dopamine Dynamics in a Nonhuman Primate Model of Recreational Cocaine Use
J. Neurosci.,
September 15, 2000;
20(18):
7109 - 7115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. W. Bradberry, R. L. Barrett-Larimore, P. Jatlow, and S. R. Rubino
Impact of Self-Administered Cocaine and Cocaine Cues on Extracellular Dopamine in Mesolimbic and Sensorimotor Striatum in Rhesus Monkeys
J. Neurosci.,
May 15, 2000;
20(10):
3874 - 3883.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Porrino and D. Lyons
Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models
Cereb Cortex,
March 1, 2000;
10(3):
326 - 333.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Hemby, C. Co, S. I. Dworkin, and J. E. Smith
Synergistic Elevations in Nucleus Accumbens Extracellular Dopamine Concentrations during Self-Administration of Cocaine/Heroin Combinations (Speedball) in Rats
J. Pharmacol. Exp. Ther.,
January 1, 1999;
288(1):
274 - 280.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. I. Bolla, J.-L. Cadet, and E. D. London
The Neuropsychiatry of Chronic Cocaine Abuse
J Neuropsychiatry Clin Neurosci,
August 1, 1998;
10(3):
280 - 289.
[Abstract]
[Full Text]
|
|
|
|
|
