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Journal of Neuroscience, Vol 16, 1591-1604, Copyright © 1996 by Society for Neuroscience
Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors
SM Nicola, SB Kombian and RC Malenka
Graduate Program in Neuroscience, University of California, San Francisco 94143, USA.
The effects of dopamine (DA) and the psychostimulants cocaine and
amphetamine on excitatory transmission in the nucleus accumbens (NAc) were
examined in rat NAc slices using both extracellular-field and whole-cell
patch-clamp recording. DA, cocaine, and amphetamine reversibly reduced the
excitatory synaptic responses (EPSPs/EPSCs) elicited by stimulation of
prelimbic cortical afferents. DA and amphetamine increased paired-pulse
facilitation, reduced the frequency of spontaneous miniature EPSCs
(mEPSCs), and had no effect on mEPSC amplitude, suggesting a presynaptic
mechanism for the observed reduction in excitatory synaptic transmission.
The effects of DA and amphetamine were attenuated by the D1 receptor
antagonist SCH23390 but not by the D2 receptor antagonist sulpiride. The
broad-spectrum DA receptor agonist 6,7-ADTN mimicked the effects of DA and
the psychostimulants, but neither the D1 receptor agonists SKF38393 and
SKF81297 nor the D2 receptor agonist quinpirole caused a significant
reduction in EPSP magnitude. SKF38393 at a higher concentration (100
microM) was effective in reducing the EPSP, however, and this reduction was
sensitive to SCH23390. There was no difference in the effects of DA in
cells from mutant mice lacking D1a receptors and cells from wild- type
control mice. Unilaterally lesioning the dopaminergic afferents to the NAc
using 6-hydroxydopamine attenuated the amphetamine-induced reduction in
EPSP magnitude in slices from the lesioned hemisphere but not the control
(unlesioned) hemisphere. These results indicate that DA and
psychostimulants (acting indirectly by increasing endogenous extracellular
DA levels) reduce excitatory synaptic transmission in the NAc by activating
presynaptic DA receptors with D1-like properties.
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