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Journal of Neuroscience, Vol 16, 2208-2219, Copyright © 1996 by Society for Neuroscience
Context-dependent synaptic action of glycinergic and GABAergic inputs in the dorsal cochlear nucleus
NL Golding and D Oertel
Department of Neurophysiology, University of Wisconsin, Madison 53706, USA.
Cartwheel cells are prominent interneurons in the dorsal cochlear nucleus
(DCN) that bear considerable homology to cerebellar Purkinje cells. They
contact other cartwheel cells as well as fusiform cells, the principal
cells of the DCN. In fusiform cells, the inhibition from cartwheel cells
interacts with excitation mediated by granule cells and auditory nerve
fibers, and shapes the output of the DCN in its ascent to the inferior
colliculi. With intracellular recordings from anatomically identified cells
in slices, synaptic inputs to fusiform and cartwheel cells were analyzed
pharmacologically. Shocks to the auditory nerve and granule cell domains
evoked glutamatergic, glycinergic, and GABA(A)ergic postsynaptic potentials
(PSPs) in both cartwheel and fusiform cells. The temporal patterns of
spontaneous and evoked glycinergic PSPs in fusiform and cartwheel cells
were similar and mirrored the pattern of firing of cartwheel cells,
probably reflecting the anatomical connections between these cell types and
supporting the conclusion that cartwheel cells are glycinergic. In fusiform
cells, glycinergic and GABA(A)ergic IPSPs evoked with shocks reversed at
-68 mV on average. In marked contrast, glycinergic and GABA(A)ergic PSPs in
cartwheel cells, as well as responses to exogenous application of 50-100 mM
glycine or 100 microns muscimol, were depolarizing. Reversal potentials of
PSPs and responses to glycine and muscimol were similar and averaged -52
mV. Glycinergic and GABA(A)ergic PSPs could elicit firing from cartwheel
cells at their resting potentials, but could also reduce rapid firing
during strong depolarizations. Thus, the action of glycinergic and
GABA(A)ergic inputs on cartwheel cells depends on the electrophysiological
context in which they occur.
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