Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

HOME | SEARCH | ARCHIVE | SUBSCRIBE | CONTACT | HELP

This Article

Full Text (PDF)

Submit an eLetter

Alert me when this article is cited

Alert me when eLetters are posted

Alert me if a correction is posted

Citation Map

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Collo, G.

Articles by Buell, G.

Search for Related Content

PubMed

PubMed Citation

Articles by Collo, G.

Articles by Buell, G.

Previous Article | Next Article

Journal of Neuroscience, Vol 16, 2495-2507, Copyright © 1996 by Society for Neuroscience

ARTICLE

Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels

G Collo, RA North, E Kawashima, E Merlo-Pich, S Neidhart, A Surprenant and G Buell
Glaxo Institute for Molecular Biology, Geneva, Switzerland.
Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six proteins are 36-48 percent identical and seem to have two transmembrane segments with a large extracellular loop. Functionally, P2X5 and P2X6 receptors most resemble P2X2 and P2X4; they desensitize only slowly and do not respond to alpha beta methylene-ATP. P2X6 receptors, like P2X4, receptors, are not blocked by the antagonists suramin and pyridoxal-5-phosphate-6-azophenyl-2',4'-disulfonic acid. P2X6 and P2X5 receptors express at lower levels than P2X1-P2X4 receptors do, perhaps indicating that they do not normally form homomultimeric channels. P2X6 and P2X4 are the receptors expressed most heavily in brain, where their RNAs have a widespread and extensively overlapping distribution. The spinal cord expresses all receptors except P2X3. P2X2, P2X4, and P2X6, are the most abundant in the dorsal horn. Sensory neurons of the trigeminal, dorsal root, and nodose ganglia express all six RNAs; P2X3 is found only there. The functional properties and tissue distribution of these six P2X receptors indicate new roles for ATP-gated ion channels.

This article has been cited by other articles:

U. Gergs, P. Boknik, W. Schmitz, A. Simm, R.-E. Silber, and J. Neumann
A positive inotropic effect of ATP in the human cardiac atrium
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1716 - H1723.
[Abstract] [Full Text] [PDF]

H.-Y. Zhou, H.-M. Zhang, S.-R. Chen, and H.-L. Pan
Increased C-Fiber Nociceptive Input Potentiates Inhibitory Glycinergic Transmission in the Spinal Dorsal Horn
J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 1000 - 1010.
[Abstract] [Full Text] [PDF]

C. Kibaly, L. Meyer, C. Patte-Mensah, and A. G. Mensah-Nyagan
Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord
FASEB J, January 1, 2008; 22(1): 93 - 104.
[Abstract] [Full Text] [PDF]

A. Tashiro, K. Okamoto, S. B. Milam, and D. A. Bereiter
Differential Effects of Estradiol on Encoding Properties of TMJ Units in Laminae I and V at the Spinomedullary Junction in Female Rats
J Neurophysiol, December 1, 2007; 98(6): 3242 - 3253.
[Abstract] [Full Text] [PDF]

Z. G. Huang, K. J. S. Griffioen, X. Wang, O. Dergacheva, H. Kamendi, C. Gorini, and D. Mendelowitz
Nicotinic Receptor Activation Occludes Purinergic Control of Central Cardiorespiratory Network Responses to Hypoxia/Hypercapnia
J Neurophysiol, October 1, 2007; 98(4): 2429 - 2438.
[Abstract] [Full Text] [PDF]

N. P. Barrera, R. M. Henderson, R. D. Murrell-Lagnado, and J. M. Edwardson
The Stoichiometry of P2X2/6 Receptor Heteromers Depends on Relative Subunit Expression Levels
Biophys. J., July 15, 2007; 93(2): 505 - 512.
[Abstract] [Full Text] [PDF]

E. Coppi, A. M. Pugliese, S. Urbani, A. Melani, E. Cerbai, B. Mazzanti, A. Bosi, R. Saccardi, and F. Pedata
ATP Modulates Cell Proliferation and Elicits Two Different Electrophysiological Responses in Human Mesenchymal Stem Cells
Stem Cells, July 1, 2007; 25(7): 1840 - 1849.
[Abstract] [Full Text] [PDF]

K. J. Griffioen, C. Gorini, H. Jameson, and D. Mendelowitz
Purinergic P2X Receptors Mediate Excitatory Transmission to Cardiac Vagal Neurons in the Nucleus Ambiguus After Hypoxia
Hypertension, July 1, 2007; 50(1): 75 - 81.
[Abstract] [Full Text] [PDF]

G. Burnstock
Physiology and Pathophysiology of Purinergic Neurotransmission
Physiol Rev, April 1, 2007; 87(2): 659 - 797.
[Abstract] [Full Text] [PDF]

Y. Pankratov, U. Lalo, A. Verkhratsky, and R. A. North
Quantal Release of ATP in Mouse Cortex
J. Gen. Physiol., March 26, 2007; 129(3): 257 - 265.
[Abstract] [Full Text] [PDF]

A. R. Lorier, A. G. Huxtable, D. M. Robinson, J. Lipski, G. D. Housley, and G. D. Funk
P2Y1 Receptor Modulation of the Pre-Botzinger Complex Inspiratory Rhythm Generating Network In Vitro
J. Neurosci., January 31, 2007; 27(5): 993 - 1005.
[Abstract] [Full Text] [PDF]

R. L. da Silva, R. R. Resende, and H. Ulrich
Genomic Physiology: Alternative splicing of P2X6 receptors in developing mouse brain and during in vitro neuronal differentiation
Exp Physiol, January 1, 2007; 92(1): 139 - 145.
[Abstract] [Full Text] [PDF]

C. Lamont, C. Vial, R. J. Evans, and W. G. Wier
P2X1 receptors mediate sympathetic postjunctional Ca2+ transients in mesenteric small arteries
Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H3106 - H3113.
[Abstract] [Full Text] [PDF]

Y. Fujiwara and Y. Kubo
Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides
J. Physiol., October 1, 2006; 576(1): 135 - 149.
[Abstract] [Full Text] [PDF]

J. A. Sim, S. Chaumont, J. Jo, L. Ulmann, M. T. Young, K. Cho, G. Buell, R. A. North, and F. Rassendren
Altered Hippocampal Synaptic Potentiation in P2X4 Knock-Out Mice.
J. Neurosci., August 30, 2006; 26(35): 9006 - 9009.
[Abstract] [Full Text] [PDF]

S. Melnik, M. Wright, J. A. Tanner, T. Tsintsadze, V. Tsintsadze, A. D. Miller, and N. Lozovaya
Diadenosine Polyphosphate Analog Controls Postsynaptic Excitation in CA3-CA1 Synapses via a Nitric Oxide-Dependent Mechanism
J. Pharmacol. Exp. Ther., August 1, 2006; 318(2): 579 - 588.
[Abstract] [Full Text] [PDF]

H. Shiokawa, T. Nakatsuka, H. Furue, M. Tsuda, T. Katafuchi, K. Inoue, and M. Yoshimura
Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors
J. Physiol., June 15, 2006; 573(3): 753 - 763.
[Abstract] [Full Text] [PDF]

R. Hausmann, J. Rettinger, Z. Gerevich, S. Meis, M. U. Kassack, P. Illes, G. Lambrecht, and G. Schmalzing
The Suramin Analog 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic Acid (NF110) Potently Blocks P2X3 Receptors: Subtype Selectivity Is Determined by Location of Sulfonic Acid Groups
Mol. Pharmacol., June 1, 2006; 69(6): 2058 - 2067.
[Abstract] [Full Text] [PDF]

S. J. Ormond, N. P. Barrera, O. S. Qureshi, R. M. Henderson, J. M. Edwardson, and R. D. Murrell-Lagnado
An Uncharged Region within the N Terminus of the P2X6 Receptor Inhibits Its Assembly and Exit from the Endoplasmic Reticulum
Mol. Pharmacol., May 1, 2006; 69(5): 1692 - 1700.
[Abstract] [Full Text] [PDF]

H. Z. Ruan, L. A. Birder, Z. Xiang, B. Chopra, T. Buffington, C. Tai, J. R. Roppolo, W. C. de Groat, and G. Burnstock
Expression of P2X and P2Y receptors in the intramural parasympathetic ganglia of the cat urinary bladder
Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1143 - F1152.
[Abstract] [Full Text] [PDF]

D. Yeung, K. Zablocki, C.-F. Lien, T. Jiang, S. Arkle, W. Brutkowski, J. Brown, H. Lochmuller, J. Simon, E. A. Barnard, et al.
Increased susceptibility to ATP via alteration of P2X receptor function in dystrophic mdx mouse muscle cells
FASEB J, April 1, 2006; 20(6): 610 - 620.
[Abstract] [Full Text] [PDF]

L. A. P. Chaves, E. P. Pontelli, and W. A. Varanda
P2X receptors in mouse Leydig cells
Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1009 - C1017.
[Abstract] [Full Text] [PDF]

G. Burnstock
Pathophysiology and therapeutic potential of purinergic signaling.
Pharmacol. Rev., March 1, 2006; 58(1): 58 - 86.
[Abstract] [Full Text] [PDF]

J. L. Cham, N. C. Owens, Julian. A. Barden, A. J. Lawrence, and E. Badoer
P2X purinoceptor subtypes on paraventricular nucleus neurones projecting to the rostral ventrolateral medulla in the rat
Exp Physiol, March 1, 2006; 91(2): 403 - 411.
[Abstract] [Full Text] [PDF]

D. Ferrari, A. la Sala, E. Panther, J. Norgauer, F. Di Virgilio, and M. Idzko
Activation of human eosinophils via P2 receptors: novel findings and future perspectives
J. Leukoc. Biol., January 1, 2006; 79(1): 7 - 15.
[Abstract] [Full Text] [PDF]

H.-Z. Ruan, L. A. Birder, W. C. de Groat, C. Tai, J. Roppolo, C. A. Buffington, and G. Burnstock
Localization of P2X and P2Y Receptors in Dorsal Root Ganglia of the Cat
J. Histochem. Cytochem., October 1, 2005; 53(10): 1273 - 1282.
[Abstract] [Full Text] [PDF]

A. R. Ase, R. Raouf, D. Belanger, E. Hamel, and P. Seguela
Potentiation of P2X1 ATP-Gated Currents by 5-Hydroxytryptamine 2A Receptors Involves Diacylglycerol-Dependent Kinases and Intracellular Calcium
J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 144 - 154.
[Abstract] [Full Text] [PDF]

K. K. Ford, M. Matchett, J. E. Krause, and W. Yu
The P2X3 Antagonist P1, P5-Di[inosine-5'] Pentaphosphate Binds to the Desensitized State of the Receptor in Rat Dorsal Root Ganglion Neurons
J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 405 - 413.
[Abstract] [Full Text] [PDF]

C. Y. Chiang, S. Zhang, Y. F. Xie, J. W. Hu, J. O. Dostrovsky, M. W. Salter, and B. J. Sessle
Endogenous ATP Involvement in Mustard-Oil-Induced Central Sensitization in Trigeminal Subnucleus Caudalis (Medullary Dorsal Horn)
J Neurophysiol, September 1, 2005; 94(3): 1751 - 1760.
[Abstract] [Full Text] [PDF]

C. Kennedy
P2X Receptors: Targets for Novel Analgesics?
Neuroscientist, August 1, 2005; 11(4): 345 - 356.
[Abstract] [PDF]

L. Papp, T. Balazsa, A. Kofalvi, F. Erdelyi, G. Szabo, E. S. Vizi, and B. Sperlagh
P2X Receptor Activation Elicits Transporter-Mediated Noradrenaline Release from Rat Hippocampal Slices
J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 973 - 980.
[Abstract] [Full Text] [PDF]

T. Watano, J. A. Calvert, C. Vial, I. D. Forsythe, and R. J. Evans
P2X receptor subtype-specific modulation of excitatory and inhibitory synaptic inputs in the rat brainstem
J. Physiol., August 1, 2004; 558(3): 745 - 757.
[Abstract] [Full Text] [PDF]

M. F. Jarvis, B. Bianchi, J. T. Uchic, J. Cartmell, C.-H. Lee, M. Williams, and C. Faltynek
[3H]A-317491, a Novel High-Affinity Non-Nucleotide Antagonist That Specifically Labels Human P2X2/3 and P2X3 Receptors
J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 407 - 416.
[Abstract] [Full Text] [PDF]

Y.-H. Jin, T. W. Bailey, B.-y. Li, J. H. Schild, and M. C. Andresen
Purinergic and Vanilloid Receptor Activation Releases Glutamate from Separate Cranial Afferent Terminals in Nucleus Tractus Solitarius
J. Neurosci., May 19, 2004; 24(20): 4709 - 4717.
[Abstract] [Full Text] [PDF]

C. A. Jones, C. Vial, L. A. Sellers, P. P. A. Humphrey, R. J. Evans, and I. P. Chessell
Functional Regulation of P2X6 Receptors by N-Linked Glycosylation: Identification of a Novel {alpha}{beta}-Methylene ATP-Sensitive Phenotype
Mol. Pharmacol., April 1, 2004; 65(4): 979 - 985.
[Abstract] [Full Text]

T. M. Egan and B. S. Khakh
Contribution of Calcium Ions to P2X Channel Responses
J. Neurosci., March 31, 2004; 24(13): 3413 - 3420.
[Abstract] [Full Text] [PDF]

E. Shigetomi and F. Kato
Action Potential-Independent Release of Glutamate by Ca2+ Entry through Presynaptic P2X Receptors Elicits Postsynaptic Firing in the Brainstem Autonomic Network
J. Neurosci., March 24, 2004; 24(12): 3125 - 3135.
[Abstract] [Full Text] [PDF]

R. A. North
P2X3 receptors and peripheral pain mechanisms
J. Physiol., January 15, 2004; 554(2): 301 - 308.
[Abstract] [Full Text] [PDF]

J. A. Calvert and R. J. Evans
Heterogeneity of P2X Receptors in Sympathetic Neurons: Contribution of Neuronal P2X1 Receptors Revealed Using Knockout Mice
Mol. Pharmacol., January 1, 2004; 65(1): 139 - 148.
[Abstract] [Full Text] [PDF]

B. S. Khakh, D. Gittermann, D. A. Cockayne, and A. Jones
ATP Modulation of Excitatory Synapses onto Interneurons
J. Neurosci., August 13, 2003; 23(19): 7426 - 7437.
[Abstract] [Full Text] [PDF]

K. Tsuzuki, A. Ase, P. Seguela, T. Nakatsuka, C.-Y. Wang, J.-X. She, and J. G. Gu
TNP-ATP-Resistant P2X Ionic Current on the Central Terminals and Somata of Rat Primary Sensory Neurons
J Neurophysiol, June 1, 2003; 89(6): 3235 - 3242.
[Abstract] [Full Text] [PDF]

T. Nakatsuka, K. Tsuzuki, J. X. Ling, H. Sonobe, and J. G. Gu
Distinct Roles of P2X Receptors in Modulating Glutamate Release at Different Primary Sensory Synapses in Rat Spinal Cord
J Neurophysiol, June 1, 2003; 89(6): 3243 - 3252.
[Abstract] [Full Text] [PDF]

X. Bo, L.-H. Jiang, H. L. Wilson, M. Kim, G. Burnstock, A. Surprenant, and R. A. North
Pharmacological and Biophysical Properties of the Human P2X5 Receptor
Mol. Pharmacol., June 1, 2003; 63(6): 1407 - 1416.
[Abstract] [Full Text] [PDF]

J. Rettinger and G. Schmalzing
Activation and Desensitization of the Recombinant P2X1 Receptor at Nanomolar ATP Concentrations
J. Gen. Physiol., April 28, 2003; 121(5): 451 - 461.
[Abstract] [Full Text] [PDF]

A. Zsembery, A. T. Boyce, L. Liang, J. Peti-Peterdi, P. D. Bell, and E. M. Schwiebert
Sustained Calcium Entry through P2X Nucleotide Receptor Channels in Human Airway Epithelial Cells
J. Biol. Chem., April 4, 2003; 278(15): 13398 - 13408.
[Abstract] [Full Text] [PDF]

R. Shariatmadari, P. Sipila, M. Vierula, K. Tornquist, I. Huhtaniemi, and M. Poutanen
Adenosine Triphosphate Induces Ca2+ Signal in Epithelial Cells of the Mouse Caput Epididymis Through Activation of P2X and P2Y Purinergic Receptors
Biol Reprod, April 1, 2003; 68(4): 1185 - 1192.
[Abstract] [Full Text] [PDF]

M. F. Jarvis, E. C. Burgard, S. McGaraughty, P. Honore, K. Lynch, T. J. Brennan, A. Subieta, T. van Biesen, J. Cartmell, B. Bianchi, et al.
A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
PNAS, December 24, 2002; 99(26): 17179 - 17184.
[Abstract] [Full Text] [PDF]

B. Hu, C. Y. Chiang, J. W. Hu, J. O. Dostrovsky, and B. J. Sessle
P2X Receptors in Trigeminal Subnucleus Caudalis Modulate Central Sensitization in Trigeminal Subnucleus Oralis
J Neurophysiol, October 1, 2002; 88(4): 1614 - 1624.
[Abstract] [Full Text] [PDF]

Y. V. Pankratov, U. V. Lalo, and O. A. Krishtal
Role for P2X Receptors in Long-Term Potentiation
J. Neurosci., October 1, 2002; 22(19): 8363 - 8369.
[Abstract] [Full Text] [PDF]

S. S. Wildman, S. G. Brown, M. Rahman, C. A. Noel, L. Churchill, G. Burnstock, R. J. Unwin, and B. F. King
Sensitization by Extracellular Ca2+ of Rat P2X5 Receptor and Its Pharmacological Properties Compared with Rat P2X1.
Mol. Pharmacol., October 1, 2002; 62(4): 957 - 966.
[Abstract] [Full Text] [PDF]

R. A. North
Molecular Physiology of P2X Receptors
Physiol Rev, October 1, 2002; 82(4): 1013 - 1067.
[Abstract] [Full Text] [PDF]

H. L. Wilson, S. A. Wilson, A. Surprenant, and R. A. North
Epithelial Membrane Proteins Induce Membrane Blebbing and Interact with the P2X7 Receptor C Terminus
J. Biol. Chem., September 6, 2002; 277(37): 34017 - 34023.
[Abstract] [Full Text] [PDF]

Y.-H. Jo and L. W. Role
Coordinate Release of ATP and GABA at In Vitro Synapses of Lateral Hypothalamic Neurons
J. Neurosci., June 15, 2002; 22(12): 4794 - 4804.
[Abstract] [Full Text] [PDF]

L. K. Bobanovic, S. J. Royle, and R. D. Murrell-Lagnado
P2X Receptor Trafficking in Neurons Is Subunit Specific
J. Neurosci., June 15, 2002; 22(12): 4814 - 4824.
[Abstract] [Full Text] [PDF]

A. N. Ramirez and D. L. Kunze
P2X purinergic receptor channel expression and function in bovine aortic endothelium
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2106 - H2116.
[Abstract] [Full Text] [PDF]

S. Boehm and H. Kubista
Fine Tuning of Sympathetic Transmitter Release via Ionotropic and Metabotropic Presynaptic Receptors
Pharmacol. Rev., March 1, 2002; 54(1): 43 - 99.
[Abstract] [Full Text] [PDF]

T. Nakatsuka, H. Furue, M. Yoshimura, and J. G. Gu
Activation of Central Terminal Vanilloid Receptor-1 Receptors and alpha beta -Methylene-ATP-Sensitive P2X Receptors Reveals a Converged Synaptic Activity onto the Deep Dorsal Horn Neurons of the Spinal Cord
J. Neurosci., February 15, 2002; 22(4): 1228 - 1237.
[Abstract] [Full Text] [PDF]

S. G. Brown, A. Townsend-Nicholson, K. A. Jacobson, G. Burnstock, and B. F. King
Heteromultimeric P2X1/2 Receptors Show a Novel Sensitivity to Extracellular pH
J. Pharmacol. Exp. Ther., February 1, 2002; 300(2): 673 - 680.
[Abstract] [Full Text] [PDF]

B. A. Chizh and P. Illes
P2X Receptors and Nociception
Pharmacol. Rev., December 1, 2001; 53(4): 553 - 568.
[Abstract] [Full Text] [PDF]

L. N. Naemsch, S. J. Dixon, and S. M. Sims
Activity-dependent Development of P2X7 Current and Ca2+ Entry in Rabbit Osteoclasts
J. Biol. C