QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (30) Citing Articles via Google Scholar Google Scholar Articles by Gutiérrez, H. Articles by Bermúdez-Rattoni, F. Search for Related Content PubMed PubMed Citation Articles by Gutiérrez, H. Articles by Bermúdez-Rattoni, F.

 Previous Article  |  Next Article 

Volume 17, Number 10, Issue of May 15, 1997 pp. 3796-3803
Copyright ©1997 Society for Neuroscience

Learning Impairment and Cholinergic Deafferentation after Cortical Nerve Growth Factor Deprivation

Received Nov. 18, 1996; revised Feb. 14, 1997; accepted Feb. 21, 1997.

Humberto Gutiérrez, María Isabel Miranda, and Federico Bermúdez-Rattoni

Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510 Mexico D. F., Mexico

Cholinergic basal forebrain (CBF ) neurons have been shown to respond in vivo to exogenous administration of NGF. Although neurotrophins and their receptors are widely expressed in the CNS, little data exist for the physiological significance of endogenous neurotrophin signaling in CNS neurons. To test directly whether cortically derived NGF is functionally required for the cholinergic functions mediated by the cerebral cortex, repeated injections of anti-NGF mAbs were locally applied into the insular cortex (IC) of rats. The biochemical results, using an in vivo microdialysis technique, showed a dramatic lack of extracellular release of acetylcholine after high potassium stimulation compared with controls. Furthermore, by using small injections of the neurotracer fluorogold, we found a corresponding disruption in the connectivity between the IC and the CBF. Behavioral experiments showed that the NGF antibodies applied into the IC produced a significant disruption on the acquisition of conditioned taste aversion and inhibitory avoidance learning. However, the same animals were able to recall the taste aversion when the conditioning trial was established before injections of NGF antibodies. Given these results, it seems that cortical cholinergic functions are actively dependent on locally derived NGF in the adult normal brain, and that the cholinergic activity from the CBF is not necessary for recalling aversive stimuli, but is necessary for the acquisition of aversively motivated conditionings.

Key words: inhibitory avoidance; conditioned taste aversion; anti-NGF antibodies; memory; cholinergic basal forebrain; cortical cholinergic activity

This article has been cited by other articles:

				C. M. Hernandez, D. A. Gearhart, V. Parikh, E. J. Hohnadel, L. W. Davis, M. L. Middlemore, S. P. Warsi, J. L. Waller, and A. V. Terry Jr Comparison of Galantamine and Donepezil for Effects on Nerve Growth Factor, Cholinergic Markers, and Memory Performance in Aged Rats J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 679 - 694. [Abstract] [Full Text] [PDF]

				N. Prakash, S. Cohen-Cory, S. Penschuck, and R. D. Frostig Basal Forebrain Cholinergic System Is Involved in Rapid Nerve Growth Factor (NGF)-Induced Plasticity in the Barrel Cortex of Adult Rats J Neurophysiol, January 1, 2004; 91(1): 424 - 437. [Abstract] [Full Text]

				M. I. Miranda, G. Ferreira, L. Ramirez-Lugo, and F. Bermudez-Rattoni Glutamatergic activity in the amygdala signals visceral input during taste memory formation PNAS, August 20, 2002; 99(17): 11417 - 11422. [Abstract] [Full Text] [PDF]

				C.-W. Xie, D. Sayah, Q.-S. Chen, W.-Z. Wei, D. Smith, and X. Liu Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene PNAS, June 23, 2000; (2000) 140204597. [Abstract] [Full Text]

				H. Gutierrez, R. Gutierrez, L. Ramirez-Trejo, R. Silva-Gandarias, C. E. Ormsby, M. I. Miranda, and F. Bermudez-Rattoni Redundant Basal Forebrain Modulation in Taste Aversion Memory Formation J. Neurosci., September 1, 1999; 19(17): 7661 - 7669. [Abstract] [Full Text] [PDF]

				M. I. Miranda and F. Bermudez-Rattoni Reversible inactivation of the nucleus basalis magnocellularis induces disruption of cortical acetylcholine release and acquisition, but not retrieval, of aversive memories PNAS, May 25, 1999; 96(11): 6478 - 6482. [Abstract] [Full Text] [PDF]

				E. Galarraga, S. Hernandez-Lopez, A. Reyes, I. Miranda, F. Bermudez-Rattoni, C. Vilchis, and J. Bargas Cholinergic Modulation of Neostriatal Output: A Functional Antagonism between Different Types of Muscarinic Receptors J. Neurosci., May 1, 1999; 19(9): 3629 - 3638. [Abstract] [Full Text] [PDF]

				A. E. Power, L. J. Thal, and J. L. McGaugh Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdala PNAS, February 19, 2002; 99(4): 2315 - 2319. [Abstract] [Full Text] [PDF]

				C.-W. Xie, D. Sayah, Q.-S. Chen, W.-Z. Wei, D. Smith, and X. Liu Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene PNAS, July 5, 2000; 97(14): 8116 - 8121. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help