QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Emmi, A. Articles by Stewart, J. Search for Related Content PubMed PubMed Citation Articles by Emmi, A. Articles by Stewart, J.

 Previous Article  |  Next Article 

Volume 17, Number 10, Issue of May 15, 1997 pp. 3840-3846
Copyright ©1997 Society for Neuroscience

Behavioral and Neurochemical Recovery from Partial 6-Hydroxydopamine Lesions of the Substantia Nigra Is Blocked by Daily Treatment with D1/D5, But Not D2, Dopamine Receptor Antagonists

Received Dec. 23, 1996; revised Feb. 18, 1997; accepted Feb. 21, 1997.

Adriana Emmi, Heshmat Rajabi, and Jane Stewart

Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Quebec, Canada H3G 1M8

To determine whether D1/D5 dopamine (DA) receptors play a role in normalization of DA extracellular levels of striatal DA and behavioral recovery after partial 6-OHDA lesions of the substantia nigra, animals were treated on days 1-8 after lesioning with the D1/D5 DA receptor antagonists SCH 23390 (0.1 mg/kg, s.c.) and SCH 39166 (1.0 mg/kg, s.c.), the inactive enantiomer SCH 23388 (0.1 mg/kg, s.c.), the D2 antagonist eticlopride (0.1 mg/kg, i.p.), or saline. Spontaneous turning behavior was assessed on days 3 and 15. Basal extracellular DA and metabolites were measured in both striata using microdialysis on days 16 and 17, 8-9 d after termination of drug treatments. On day 3, all animals turned ipsilateral to the lesion. On day 15, animals previously treated with either saline, eticlopride, or SCH 23388 showed no behavioral asymmetries, whereas animals treated with SCH 23390 or SCH 39166 turned ipsilaterally. On days 16 and 17, extracellular DA did not differ on the two sides in animals treated with saline or eticlopride and were higher on the lesioned side after SCH 23388. In animals treated with the D1/D5 receptor antagonists, however, basal levels of DA were lower on the lesioned side, showing no evidence of normalization. These results suggest a role for the D1/D5 DA receptor in the development of compensatory changes in the DA neurons that accompany behavioral recovery from partial lesions of nigrostriatal DA system.

Key words: substantia nigra; 6-OHDA lesions; behavioral recovery; striatal dopamine; microdialysis; D1/D5 receptor antagonists; D2 receptor antagonists

This article has been cited by other articles:

				J. L. Tillerson, A. D. Cohen, J. Philhower, G. W. Miller, M. J. Zigmond, and T. Schallert Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine J. Neurosci., June 15, 2001; 21(12): 4427 - 4435. [Abstract] [Full Text] [PDF]

				C. Flores, D. Rodaros, and J. Stewart Long-Lasting Induction of Astrocytic Basic Fibroblast Growth Factor by Repeated Injections of Amphetamine: Blockade by Concurrent Treatment with a Glutamate Antagonist J. Neurosci., November 15, 1998; 18(22): 9547 - 9555. [Abstract] [Full Text] [PDF]

				C. Zhang, J. P. Steiner, G. S. Hamilton, T. P. Hicks, and M. O. Poulter Regeneration of Dopaminergic Function in 6-Hydroxydopamine-Lesioned Rats by Neuroimmunophilin Ligand Treatment J. Neurosci., August 1, 2001; 21(15): RC156 - RC156. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help