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Volume 17, Number 11, Issue of June 1, 1997 pp. 4149-4158
Copyright ©1997 Society for NeuroscienceThe Characterization of the Olf-1/EBF-Like HLH Transcription Factor Family: Implications in Olfactory Gene Regulation and Neuronal Development
Received Jan. 22, 1997; revised March 12, 1997; accepted March 19, 1997.
Song S. Wang, Robert Y. L. Tsai, and Randall R. Reed The Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, and Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
The Olf-1/EBF helix-loop-helix (HLH) transcription factor has been implicated in olfactory gene regulation and in B-cell development. Using homology screening methods, we identified two additional Olf-1/EBF-like cDNAs from a mouse embryonic cDNA library. The Olf-1/EBF-like (O/E) proteins O/E-1, O/E-2, and O/E-3 define a family of transcription factors that share structural similarities and biochemical activities. Although these O/E genes are expressed within olfactory epithelium in an identical pattern, they exhibit different patterns of expression in the developing nervous system. Although O/E-1 mRNA is present in several tissues in addition to olfactory neurons and developing B-cells, O/E-2 and O/E-3 are expressed at high levels only in olfactory tissue. In O/E-1 knock-out animals, the presence of two additional O/E family members in olfactory neurons may provide redundancy and allow normal olfactory neurodevelopment. Further, the identification of the O/E family of HLH transcription factors and their embryonic expression patterns suggest that the O/E proteins may have a more general function in neuronal development.
Key words: Olf-1/EBF; O/E; olfactory gene regulation; neurodevelopment; sensory neurons; differentiation and maturation; transcription factors
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