QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (60) Citing Articles via Google Scholar Google Scholar Articles by Rivera, S. Articles by Khrestchatisky, M. Search for Related Content PubMed PubMed Citation Articles by Rivera, S. Articles by Khrestchatisky, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CYCLOHEXIMIDE Medline Plus Health Information Seizures

 Previous Article  |  Next Article 

Volume 17, Number 11, Issue of June 1, 1997 pp. 4223-4235
Copyright ©1997 Society for Neuroscience

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Is Differentially Induced in Neurons and Astrocytes after Seizures: Evidence for Developmental, Immediate Early Gene, and Lesion Response

Received Nov. 20, 1996; revised Feb. 25, 1997; accepted March 25, 1997.

Santiago Rivera, Evelyne Tremblay, Serge Timsit, Oriol Canals, Yezekiel Ben-Ari, and Michel Khrestchatisky

Université René Descartes, Paris V, Institut National de la Santé et de la Recherche Médicale Unité-29, 75014 Paris, France

We investigated in vivo the expression of the tissue inhibitor of metalloproteinases-1 (TIMP-1) in the rat CNS after kainate (KA)-induced excitotoxic seizures. In situ hybridization revealed that TIMP-1 mRNA is induced rapidly and massively in most regions of the adult forebrain after KA treatment. Neuronal activity seems to be necessary but not sufficient to trigger TIMP-1 induction, because it is not observed in seizing 10-d-old pups, unlike what is observed in 21- and 35-d-old animals after seizures. The rapid induction of TIMP-1 is not prevented by the inhibitor of protein synthesis cycloheximide, suggesting that, after seizures, TIMP-1 is induced in neurons as an immediate early gene (IEG). The initial neuronal upregulation is followed by enhanced expression in astrocytes, as assessed by double-labeling experiments. In the hippocampus rapid increases in mRNA are followed by relatively delayed (8 hr after KA) increases in TIMP-1 immunoreactivity in the perisomatic and dendro-axonic areas, suggesting secretion of the protein. At 3 d after KA treatment, strong immunoreactivity is found in astrocytes and in the cell bodies and dendro-axonic projections of resistant neurons such as the dentate granule cells. Taken together, the results suggest that TIMP-1 may be instrumental for neurons and astrocytes in coupling early cellular events triggered by seizures with the regulation of long-lasting changes involved in tissue reorganization and/or neuroprotection.

Key words: TIMP-1; protease inhibitor; brain seizures; neuronal death; immediate early gene; astrocytes; extracellular matrix; tissue remodeling

This article has been cited by other articles:

				O. Bozdagi, V. Nagy, K. T. Kwei, and G. W. Huntley In Vivo Roles for Matrix Metalloproteinase-9 in Mature Hippocampal Synaptic Physiology and Plasticity J Neurophysiol, July 1, 2007; 98(1): 334 - 344. [Abstract] [Full Text] [PDF]

				M. A. Bruno and A. C. Cuello Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade PNAS, April 25, 2006; 103(17): 6735 - 6740. [Abstract] [Full Text] [PDF]

				V. Nagy, O. Bozdagi, A. Matynia, M. Balcerzyk, P. Okulski, J. Dzwonek, R. M. Costa, A. J. Silva, L. Kaczmarek, and G. W. Huntley Matrix Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term Potentiation and Memory J. Neurosci., February 15, 2006; 26(7): 1923 - 1934. [Abstract] [Full Text] [PDF]

				S. S. Newton, E. F. Collier, J. Hunsberger, D. Adams, R. Terwilliger, E. Selvanayagam, and R. S. Duman Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors J. Neurosci., November 26, 2003; 23(34): 10841 - 10851. [Abstract] [Full Text] [PDF]

				S. Lorenzl, G. De Pasquale, A. Z. Segal, M. F. Beal, M. Castellanos, J. Castillo, and A. Davalos Dysregulation of the Levels of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in the Early Phase of Cerebral Ischemia * Response Stroke, June 1, 2003; 34 (6): e37 - e38. [Full Text] [PDF]

				A. Szklarczyk, J. Lapinska, M. Rylski, R. D. G. McKay, and L. Kaczmarek Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus J. Neurosci., February 1, 2002; 22(3): 920 - 930. [Abstract] [Full Text] [PDF]

				S.-T. Khuth, H. Akaoka, A. Pagenstecher, O. Verlaeten, M.-F. Belin, P. Giraudon, and A. Bernard Morbillivirus Infection of the Mouse Central Nervous System Induces Region-Specific Upregulation of MMPs and TIMPs Correlated to Inflammatory Cytokine Expression J. Virol., September 1, 2001; 75(17): 8268 - 8282. [Abstract] [Full Text] [PDF]

				P. Giraudon, R. Szymocha, S. Buart, A. Bernard, L. Cartier, M.-F. Belin, and H. Akaoka T Lymphocytes Activated by Persistent Viral Infection Differentially Modify the Expression of Metalloproteinases and Their Endogenous Inhibitors, TIMPs, in Human Astrocytes: Relevance to HTLV-I-Induced Neurological Disease J. Immunol., March 1, 2000; 164(5): 2718 - 2727. [Abstract] [Full Text] [PDF]

				J. Jaworski, I. W. Biedermann, J. Lapinska, A. Szklarczyk, I. Figiel, D. Konopka, D. Nowicka, R. K. Filipkowski, M. Hetman, A. Kowalczyk, et al. Neuronal Excitation-driven and AP-1-dependent Activation of Tissue Inhibitor of Metalloproteinases-1 Gene Expression in Rodent Hippocampus J. Biol. Chem., October 1, 1999; 274(40): 28106 - 28112. [Abstract] [Full Text] [PDF]

				S. E. Tsirka, T. H. Bugge, J. L. Degen, and S. Strickland Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin PNAS, September 2, 1997; 94(18): 9779 - 9781. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help