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Volume 17, Number 12, Issue of June 15, 1997 pp. 4829-4838
Copyright ©1997 Society for NeuroscienceVentral Prefrontal Cortex Is Not Essential for Working Memory
Received Oct. 18, 1996; revised March 18, 1997; accepted March 27, 1997.
Matthew F. S. Rushworth1, Philip D. Nixon1, Madeline J. Eacott2, and Richard E. Passingham1 1 Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom, and 2 Department of Psychology, University of Durham Durham, DH1 3LE, United Kingdom
It is widely held that the prefrontal cortex is important for working memory. It has been suggested that the inferior convexity (IC) may play a special role in working memory for form and color (). We have therefore assessed the ability of monkeys with IC lesions to perform visual pattern association tasks and color-matching tasks, both with and without delay. In experiment 1, six monkeys were trained on a visual association task with delays of up to 2 sec. Conservative IC lesions that removed lateral area 47/12 in three animals had no effect on the task. Further experiments showed that these lesions had no effect on the postoperative new learning of a color-matching task with delays of up to 2 sec or versions of the visual association task involving delays of up to 8 sec. In experiment 2, larger lesions of both areas 47/12 and 45A were made in the three control animals. This lesion caused a profound deficit in the ability to relearn simultaneous color matching, but subsequent matching with delays of up to 8 sec was clearly unimpaired. We suggest that the IC may be more important for stimulus selection and attention as opposed to working memory.
Key words: prefrontal cortex; working memory; inferior convexity; area 12; area 47; object vision; positron emission tomography
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