QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by McGivern, R. F. Articles by Redei, E. Search for Related Content PubMed PubMed Citation Articles by McGivern, R. F. Articles by Redei, E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information Stress

 Previous Article  |  Next Article 

Volume 17, Number 12, Issue of June 15, 1997 pp. 4886-4894
Copyright ©1997 Society for Neuroscience

Inhibition of Stress-Induced Neuroendocrine and Behavioral Responses in the Rat by Prepro-Thyrotropin-Releasing Hormone 178-199

Received Jan. 29, 1997; revised April 1, 1997; accepted April 8, 1997.

Robert F. McGivern¹, Peter Rittenhouse², Fraser Aird², Louis D. Van de Kar³, and Eva Redei²

¹ Department of Psychology, San Diego State University, San Diego, California 92182, ² Departments of Pharmacology and Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and ³ Department of Pharmacology, Loyola University, Maywood, Illinois 60153

A corticotropin release-inhibiting factor (CRIF) in brain has been postulated for several decades, based on increased plasma levels of ACTH and corticosterone after hypothalamic-pituitary disconnection. Recent in vitro studies indicate that prepro-TRH178-199 may function as an endogenous CRIF, prompting us to examine stress-related neuroendocrine and behavioral responses after in vivo administration to the adult male rat. Animals that were administered prepro-TRH178-199 intravenously 5 min before restraint stress exhibited a significant attenuation of stress-induced elevations of ACTH, corticosterone, and prolactin, as compared with controls infused with vehicle, whereas thyroid-stimulating hormone (TSH) secretion was not changed.

In behavioral studies of stress responsiveness, either the vehicle or prepro-TRH178-199 was administered intracerebroventricularly (ICV) 5 min before testing. In the open field, prepro-TRH178-199 significantly increased grooming, locomotor activity, rearing, and sniffing behaviors. In the light/dark box, it significantly increased the time animals spent in the light compartment and increased the number of crossings between the light/dark compartments. In the plus maze, the peptide significantly increased the amount of time animals spent in the open arms. The same dose of peptide, administered ICV, had no effect on peripheral hormone release in response to restraint stress. Overall, these results support a role for prepro-TRH178-199 in the inhibition of the neuroendocrine responses to stress at the level of the pituitary and indicate that it has central modulatory influences over stress-related behaviors.

Key words: ACTH; corticosterone; TSH; prolactin; stress; plus maze; light/dark box; arousal; grooming; activity; CRF; CRIF; TRH

This article has been cited by other articles:

				K. Vandenborne, S. A Roelens, V. M Darras, E. R Kuhn, and S. Van der Geyten Cloning and hypothalamic distribution of the chicken thyrotropin-releasing hormone precursor cDNA J. Endocrinol., August 1, 2005; 186(2): 387 - 396. [Abstract] [Full Text] [PDF]

				J. Slone-Wilcoxon and E. E. Redei Maternal-Fetal Glucocorticoid Milieu Programs Hypothalamic-Pituitary-Thyroid Function of Adult Offspring Endocrinology, September 1, 2004; 145(9): 4068 - 4072. [Abstract] [Full Text] [PDF]

				E. A. Nillni, W. Xie, L. Mulcahy, V. C. Sanchez, and W. C. Wetsel Deficiencies in Pro-thyrotropin-releasing Hormone Processing and Abnormalities in Thermoregulation in Cpefat/fatMice J. Biol. Chem., December 6, 2002; 277(50): 48587 - 48595. [Abstract] [Full Text] [PDF]

				E. A. Nillni, F. Aird, N. G. Seidah, R. B. Todd, and J. I. Koenig PreproTRH178-199 and Two Novel Peptides (pFQ7 and pSE14) Derived from Its Processing, Which Are Produced in the Paraventricular Nucleus of the Rat Hypothalamus, Are Regulated during Suckling Endocrinology, February 1, 2001; 142(2): 896 - 906. [Abstract] [Full Text] [PDF]

				E. A. Nillni and K. A. Sevarino The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides Endocr. Rev., October 1, 1999; 20(5): 599 - 648. [Abstract] [Full Text]

				D. Engler, E. Redei, and I. Kola The Corticotropin-Release Inhibitory Factor Hypothesis: A Review of the Evidence for the Existence of Inhibitory as Well as Stimulatory Hypophysiotropic Regulation of Adrenocorticotropin Secretion and Biosynthesis Endocr. Rev., August 1, 1999; 20(4): 460 - 500. [Abstract] [Full Text] [PDF]

				K. Valentijn, F. Vandenbulcke, E. Piek, J.-C. Beauvillain, and H. Vaudry Distribution, Cellular Localization, and Ontogeny of Preprothyrotropin-Releasing Hormone-(160-169) (Ps4)-Binding Sites in the Rat Pituitary Endocrinology, March 1, 1998; 139(3): 1306 - 1313. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help