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Next Article 
Volume 17, Number 17,
Issue of September 1, 1997
pp. 6493-6503
Copyright ©1997 Society for Neuroscience
 -Adrenergic Stimulation Selectively Inhibits Long-Lasting
L-Type Calcium Channel Facilitation in Hippocampal Pyramidal
Neurons
Received Feb. 6, 1997; revised June 4, 1997; accepted June 10, 1997.
Robin K. Cloues,
Steven J. Tavalin, and
Neil V. Marrion
Vollum Institute, Oregon Health Sciences University, Portland,
Oregon 97201-3098
L-type calcium channels are abundant in hippocampal pyramidal
neurons and are highly clustered at the base of the major dendrites. However, little is known of their function in these neurons.
Single-channel recording using a low concentration of permeant ion
reveals a long-lasting facilitation of L-type channel activity that is
induced by a depolarizing prepulse or a train of action potential
waveforms. This facilitation exhibits a slow rise, peaking 0.5-1 sec
after the train and decaying over several seconds. We have termed this behavior "delayed facilitation," because of the slow onset. Delayed facilitation results from an increase in opening frequency and the
recruitment of longer duration openings. This behavior is observed at
all membrane potentials between  20 and 60 mV, with the induction
and magnitude of facilitation being insensitive to voltage.
 -Adrenergic receptor activation blocks induction of delayed
facilitation but does not significantly affect normal L-type channel
activity. Delayed facilitation of L-type calcium channels provides a
prolonged source of calcium entry at negative membrane potentials. This
behavior may underlie calcium-dependent events that are inhibited by
-adrenergic receptor activation, such as the slow
afterhyperpolarization in hippocampal neurons.
Key words:
calcium channel;
L-type;
modulation;
facilitation;
hippocampus;
single channel
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