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Volume 17, Number 17,
Issue of September 1, 1997
pp. 6707-6716
Copyright ©1997 Society for Neuroscience
Brain-Derived Neurotrophic Factor Enhances Long-Term Potentiation
in Rat Visual Cortex
Received April 23, 1997; revised June 20, 1997; accepted June 23, 1997.
Yukio Akaneya1,
Tadaharu Tsumoto1,
Shuichiro Kinoshita1, and
Hiroshi Hatanaka2
1 Department of Neurophysiology, Biomedical Research
Center, Osaka University Medical School, Suita City, 565 Japan, and
2 Division of Protein Biosynthesis, Institute for Protein
Research, Osaka University, Suita City, 565 Japan
Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3),
members of the nerve growth factor (NGF) gene family, have been
suggested to play a role in experience-dependent modification of neural
networks in the developing nervous system. In this study we addressed
the question of whether these neurotrophins are involved in long-term
potentiation (LTP) in developing visual cortex. We recorded layer
II/III field potentials and whole-cell currents evoked by test
stimulation of layer IV at 0.1 Hz in visual cortical slices prepared
from young rats (postnatal day 15-25) and observed effects of BDNF,
NT-3, and NGF on these responses. Then we analyzed the effects of these
neurotrophins on LTP induced by tetanic ( -burst type) stimulation of
layer IV. We found that BDNF at 200 ng/ml potentiated field potentials
and EPSCs in most cases and that this potentiation lasted after
cessation of the BDNF application. At the concentration of 20 ng/ml,
BDNF did not show such an effect, but it enhanced the magnitude of
expressed LTP. On the other hand, NT-3 and NGF had none of these
effects. Immunohistochemical staining of slices with antibody against
BDNF showed that exogenous BDNF penetrated into the whole slice within
~5 min of its application. The actions of BDNF were blocked by
preincubation of slices with TrkB-IgG fusion protein, a BDNF scavenger,
or coapplication of K252a, an inhibitor for receptor tyrosine kinases.
TrkB-IgG or K252a itself completely blocked LTP, suggesting that
endogenous BDNF or another TrkB ligand plays a role in LTP in the
developing visual cortex.
Key words:
brain-derived neurotrophic factor;
long-term
potentiation;
nerve growth factor;
neurotrophin-3;
visual cortex;
synaptic plasticity
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|
|
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|
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6(3):
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[Abstract]
[Full Text]
|
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
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18(24):
10231 - 10240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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18(21):
8730 - 8739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
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95(17):
10235 - 10239.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. Morrison and C. A. Mason
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J. Neurosci.,
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18(10):
3563 - 3573.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W Haubensak, F Narz, R Heumann, and V Lessmann
BDNF-GFP containing secretory granules are localized in the vicinity of synaptic junctions of cultured cortical neurons
J. Cell Sci.,
January 6, 1998;
111(11):
1483 - 1493.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Canossa, E. Giordano, S. Cappello, C. Guarnieri, and S. Ferri
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March 5, 2002;
99(5):
3282 - 3287.
[Abstract]
[Full Text]
[PDF]
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|
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|
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|
Y. Yin, G. M. Edelman, and P. W. Vanderklish
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February 19, 2002;
99(4):
2368 - 2373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. Kossel, S. B. Cambridge, U. Wagner, and T. Bonhoeffer
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PNAS,
December 4, 2001;
98(25):
14702 - 14707.
[Abstract]
[Full Text]
[PDF]
|
|
|
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