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 Previous Article
Volume 17, Number 19,
Issue of October 1, 1997
pp. 7565-7581
Copyright ©1997 Society for Neuroscience
Intracellular Recordings in Response to Monaural and Binaural
Stimulation of Neurons in the Inferior Colliculus of the Cat
Received May 16, 1997; revised July 21, 1997; accepted July 23, 1997.
Shigeyuki Kuwada1,
Ranjan Batra1,
Tom C. T. Yin2,
Douglas L. Oliver1,
Lewis B. Haberly3, and
Terrence R. Stanford4
1 Department of Anatomy, University of Connecticut
Health Center, Farmington, Connecticut 06032, Departments of
2 Neurophysiology and 3 Anatomy, University of
Wisconsin Medical School, Madison, Wisconsin 53706, and
4 Department of Neurobiology and Anatomy, Wake Forest
University, Bowman Gray School of Medicine, Winston-Salem, North
Carolina 27157
The inferior colliculus (IC) is a major auditory structure that
integrates synaptic inputs from ascending, descending, and intrinsic
sources. Intracellular recording in situ allows direct examination of synaptic inputs to the IC in response to acoustic stimulation. Using this technique and monaural or binaural stimulation, responses in the IC that reflect input from a lower center can be
distinguished from responses that reflect synaptic integration within
the IC. Our results indicate that many IC neurons receive synaptic
inputs from multiple sources. Few, if any, IC neurons acted as simple
relay cells. Responses often displayed complex interactions between
excitatory and inhibitory sources, such that different synaptic
mechanisms could underlie similar response patterns. Thus, it may be an
oversimplification to classify the responses of IC neurons as simply
excitatory or inhibitory, as is done in many studies. In addition,
inhibition and intrinsic membrane properties appeared to play key roles
in creating de novo temporal response patterns in the
IC.
Key words:
inferior colliculus;
intracellular recordings;
auditory
pathways;
auditory signal processing;
binaural hearing;
synaptic
physiology
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