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Volume 17, Number 2, Issue of January 15, 1997 pp. 516-529
Copyright ©1997 Society for NeurosciencePlastic Neuronal Remodeling Is Impaired in Patients with Alzheimer's Disease Carrying Apolipoprotein
4 Allele
Received June 21, 1996; revised Oct. 16, 1996; accepted Oct. 23, 1996.
Thomas Arendt1, Cornelia Schindler2, Martina K. Brückner1, Klaus Eschrich2, Volker Bigl1, Dyrk Zedlick3, and Lena Marcova4 1 Department of Neurochemistry, Paul Flechsig Institute of Brain Research, Leipzig, Germany, 2 Institute of Biochemistry and 3 Hospital for Psychiatry, University of Leipzig, Leipzig, Germany, and 4 Institute of Brain Research, Medical Academy of Russia, Moscow, Russia
A relationship between the apolipoprotein E (apoE) genotype and the risk to develop Alzheimer's disease has been established recently. Apolipoprotein synthesis is implicated in developmental processes and in neuronal repair of the adult nervous system.
In the present study, we investigated the influence of the apolipoprotein polymorphism on the severity of neuronal degeneration and the extent of plastic dendritic remodeling in Alzheimer's disease. Changes in length and arborization of dendrites of Golgi-impregnated neurons in the basal nucleus of Meynert, locus coeruleus, raphe magnus nucleus, medial amygdaloid nucleus, pedunculopontine tegmental nucleus, and substantia nigra were analyzed after three-dimensional reconstruction. Patients with either one or two apoE
4 alleles not only showed a more severe degeneration in all areas investigated than in patients lacking the apoE 4 allele but also revealed significantly less plastic dendritic changes. ApoE
The results provide direct evidence that neuronal reorganization is affected severely in patients with Alzheimer's disease carrying the apoE
Key words: Alzheimer's disease; apolipoprotein E; degeneration; dendritic sprouting; plasticity; regeneration
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