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Volume 17, Number 21, Issue of November 1, 1997 pp. 8293-8299
Copyright ©1997 Society for Neuroscience

Activation of ErbB2 during Wallerian Degeneration of Sciatic Nerve

Received June 19, 1997; revised Aug. 5, 1997; accepted Aug. 11, 1997.

Yunhee Kim Kwon^{1, 2}, Anita Bhattacharyya², John A. Alberta², William V. Giannobile^{2, 4}, Kangwoo Cheon¹, Charles D. Stiles², and Scott L. Pomeroy³

¹ Department of Biology, College of Arts and Sciences, KyungHee University, Seoul, 130-701 Korea, ² Department of Microbiology and Molecular Genetics, Harvard Medical School and the Dana-Farber Cancer Institute, Boston, Massachusetts 02115, ³ Department of Neurology, Harvard Medical School and Children's Hospital, Boston, Massachusetts 02115, and ⁴ Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts 02115

We used anti-phosphopeptide-immunodetecting antibodies as immunohistochemical reagents to define the location and activity state of p185^erbB2 during Wallerian degeneration. Nerve damage induces a phosphorylation event at Y1248, a site that couples p185^erbB2 to the Ras-Raf-MAP kinase signal transduction pathway. Phosphorylation of p185^erbB2 occurs within Schwann cells and coincides in time and space with Schwann cell mitotic activity, as measured by bromodeoxyuridine uptake. These visual images of receptor autophosphorylation link activation of p185^erbB2 to the Schwann cell proliferation that accompanies nerve regeneration.

Key words: neuregulin; erbB2; receptor tyrosine kinase; Schwann cell; Wallerian degeneration; phosphotyrosine

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