 |
 Previous Article | Next Article 
Volume 17, Number 21,
Issue of November 1, 1997
pp. 8580-8587
Copyright ©1997 Society for Neuroscience
Role of Dopamine D1 and D2 Receptors in
the Nucleus Accumbens in Mediating Reward
Received June 24, 1997; revised Aug. 11, 1997; accepted Aug. 20, 1997.
Satoshi Ikemoto1,
Bradley S. Glazier1,
James
M. Murphy1, 2, and
William J. McBride1
1 Institute of Psychiatric Research, Department of
Psychiatry, Indiana University School of Medicine and
2 Department of Psychology, Purdue School of Science,
Indiana University-Purdue University at Indianapolis, Indianapolis,
Indiana 46202
The objectives of this study were to examine the involvement of
D1 and D2 receptors within the nucleus
accumbens (ACB) in mediating reinforcement. The intracranial
self-administration (ICSA) of D1 and D2
agonists was used to determine whether activating D1 and/or
D2 receptors within the ACB of Wistar rats is reinforcing. At concentrations of 0.25, 0.50, and 1.0 mM (25, 50, and
100 pmol/100 nl of infusion), neither the D1 agonist
R(+)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol [SKF 38393 (SKF)] hydrochloride nor the D2 agonist
( )-quinpirole (Quin) hydrochloride was self-administered into the
shell region of the ACB. On the other hand, equimolar mixtures of SKF
and Quin (SKF+Quin), at concentrations of 0.25, 0.50, and 1.0 mM each, were significantly self-infused into the ACB
shell. The core region of the ACB did not support the ICSA of SKF+Quin
at any of these concentrations. Rats increased lever pressing when the
response requirement was increased from a fixed ratio 1 (FR1) to FR3,
and they responded significantly more on the infusion lever than they did on the control lever. Coadministration of either 0.50 mM
R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SCH 23390) hydrochloride, a D1 antagonist, or 0.50 mM S()-sulpiride, a D2
antagonist, completely abolished the ICSA of the mixture of SKF+Quin
(each at 0.50 mM) into the ACB shell. The present results
suggest that concurrent activation of D1- and
D2-type receptors in the shell of the ACB had a cooperative
effect on DA-mediated reward processes.
Key words:
dopamine D1 receptor;
dopamine D2
receptor;
SKF 38393;
quinpirole;
nucleus accumbens;
intracranial
self-administration;
reward;
reinforcement
This article has been cited by other articles:
|
|
|
|
 
S. R. Laviolette, N. M. Lauzon, S. F. Bishop, N. Sun, and H. Tan
Dopamine Signaling through D1-Like versus D2-Like Receptors in the Nucleus Accumbens Core versus Shell Differentially Modulates Nicotine Reward Sensitivity
J. Neurosci.,
August 6, 2008;
28(32):
8025 - 8033.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. J. Aragona and Z. Wang
Opposing Regulation of Pair Bond Formation by cAMP Signaling within the Nucleus Accumbens Shell
J. Neurosci.,
November 28, 2007;
27(48):
13352 - 13356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Zangen, M. Solinas, S. Ikemoto, S. R. Goldberg, and R. A. Wise
Two brain sites for cannabinoid reward.
J. Neurosci.,
May 3, 2006;
26(18):
4901 - 4907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Grant, M. N. Potenza, E. Hollander, R. Cunningham-Williams, T. Nurminen, G. Smits, and A. Kallio
Multicenter Investigation of the Opioid Antagonist Nalmefene in the Treatment of Pathological Gambling
Am J Psychiatry,
February 1, 2006;
163(2):
303 - 312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto, M. Qin, and Z.-H. Liu
Primary Reinforcing Effects of Nicotine Are Triggered from Multiple Regions Both Inside and Outside the Ventral Tegmental Area
J. Neurosci.,
January 18, 2006;
26(3):
723 - 730.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Wu and J. J. Hablitz
Cooperative Activation of D1 and D2 Dopamine Receptors Enhances a Hyperpolarization-Activated Inward Current in Layer I Interneurons
J. Neurosci.,
July 6, 2005;
25(27):
6322 - 6328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto, M. Qin, and Z.-H. Liu
The Functional Divide for Primary Reinforcement of D-Amphetamine Lies between the Medial and Lateral Ventral Striatum: Is the Division of the Accumbens Core, Shell, and Olfactory Tubercle Valid?
J. Neurosci.,
May 18, 2005;
25(20):
5061 - 5065.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. W. Hopf, W. S. Mailliard, G. F. Gonzalez, I. Diamond, and A. Bonci
Atypical Protein Kinase C Is a Novel Mediator of Dopamine-Enhanced Firing in Nucleus Accumbens Neurons
J. Neurosci.,
January 26, 2005;
25(4):
985 - 989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. A. Champagne, P. Chretien, C. W. Stevenson, T. Y. Zhang, A. Gratton, and M. J. Meaney
Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat
J. Neurosci.,
April 28, 2004;
24(17):
4113 - 4123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. L. Sellings and P. B. S. Clarke
Segregation of Amphetamine Reward and Locomotor Stimulation between Nucleus Accumbens Medial Shell and Core
J. Neurosci.,
July 16, 2003;
23(15):
6295 - 6303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. W. Hopf, M. G. Cascini, A. S. Gordon, I. Diamond, and A. Bonci
Cooperative Activation of Dopamine D1 and D2 Receptors Increases Spike Firing of Nucleus Accumbens Neurons via G-Protein {beta}{gamma} Subunits
J. Neurosci.,
June 15, 2003;
23(12):
5079 - 5087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. A. Rodd-Henricks, D. L. McKinzie, T.-K. Li, J. M. Murphy, and W. J. McBride
Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats
J. Pharmacol. Exp. Ther.,
December 1, 2002;
303(3):
1216 - 1226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto and R. A. Wise
Rewarding Effects of the Cholinergic Agents Carbachol and Neostigmine in the Posterior Ventral Tegmental Area
J. Neurosci.,
November 15, 2002;
22(22):
9895 - 9904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. B. Fredholm, K. Battig, J. Holmen, A. Nehlig, and E. E. Zvartau
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
Pharmacol. Rev.,
March 1, 1999;
51(1):
83 - 133.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Giorgetti, J. I. Javaid, J. M. Davis, E. Costa, A. Guidotti, S. B. Appel, and M. S. Brodie
Imidazenil, a Positive Allosteric GABAA Receptor Modulator, Inhibits the Effects of Cocaine on Locomotor Activity and Extracellular Dopamine in the Nucleus Accumbens Shell Without Tolerance Liability
J. Pharmacol. Exp. Ther.,
October 1, 1998;
287(1):
58 - 66.
[Abstract]
[Full Text]
|
|
|
|
