QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (45) Citing Articles via Google Scholar Google Scholar Articles by Choi, S. Articles by Lovinger, D. M. Search for Related Content PubMed PubMed Citation Articles by Choi, S. Articles by Lovinger, D. M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL STRONTIUM, ELEMENTAL TETRODOTOXIN

 Previous Article  |  Next Article 

Volume 17, Number 21, Issue of November 1, 1997 pp. 8613-8620
Copyright ©1997 Society for Neuroscience

Decreased Frequency But Not Amplitude of Quantal Synaptic Responses Associated with Expression of Corticostriatal Long-Term Depression

Received May 29, 1997; revised Aug. 11, 1997; accepted Aug. 22, 1997.

Sukwoo Choi¹ and David M. Lovinger^{1, 2}

Departments of ¹ Molecular Physiology and Biophysics and ² Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615

We have investigated the site of expression of striatal long-term synaptic depression (LTD) using analysis of Sr²⁺-induced asynchronous release of quanta from stimulated synapses. The cumulative amplitude distribution of Sr²⁺-induced asynchronous synaptic responses overlaps with that of miniature EPSCs (mEPSCs), suggesting that Sr²⁺-induced asynchronous responses are quantal. Quantal amplitude at stimulated synapses is not significantly altered after LTD induction, whereas quantal frequency decreases after LTD induction. The decrease in quantal frequency is prevented when LTD expression is blocked by dialyzing 10 mM EGTA into the postsynaptic neuron. Our findings are most consistent with the idea that expression of striatal LTD involves decreased neurotransmitter release with no change in quantal amplitude, despite the fact that induction of striatal LTD involves postsynaptic mechanisms.

Key words: long-term depression; striatum; cortex; synaptic plasticity; presynaptic expression; postsynaptic induction

This article has been cited by other articles:

				B. A. Grueter, Z. A. McElligott, A. J. Robison, G. C. Mathews, and D. G. Winder In Vivo Metabotropic Glutamate Receptor 5 (mGluR5) Antagonism Prevents Cocaine-Induced Disruption of Postsynaptically Maintained mGluR5-Dependent Long-Term Depression J. Neurosci., September 10, 2008; 28(37): 9261 - 9270. [Abstract] [Full Text] [PDF]

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				V. Pawlak and J. N. D. Kerr Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity J. Neurosci., March 5, 2008; 28(10): 2435 - 2446. [Abstract] [Full Text] [PDF]

				B. Pan, C. J. Hillard, and Q.-s. Liu Endocannabinoid Signaling Mediates Cocaine-Induced Inhibitory Synaptic Plasticity in Midbrain Dopamine Neurons J. Neurosci., February 6, 2008; 28(6): 1385 - 1397. [Abstract] [Full Text] [PDF]

				Q. Cai, P.-Y. Pan, and Z.-H. Sheng Syntabulin-Kinesin-1 Family Member 5B-Mediated Axonal Transport Contributes to Activity-Dependent Presynaptic Assembly J. Neurosci., July 4, 2007; 27(27): 7284 - 7296. [Abstract] [Full Text] [PDF]

				L. Adermark and D. M. Lovinger Combined Activation of L-Type Ca2+ Channels and Synaptic Transmission Is Sufficient to Induce Striatal Long-Term Depression J. Neurosci., June 20, 2007; 27(25): 6781 - 6787. [Abstract] [Full Text] [PDF]

				S. Singla, A. C. Kreitzer, and R. C. Malenka Mechanisms for Synapse Specificity during Striatal Long-Term Depression J. Neurosci., May 9, 2007; 27(19): 5260 - 5264. [Abstract] [Full Text] [PDF]

				J.-P. Zhao, M. A. Phillips, and M. Constantine-Paton Long-Term Potentiation in the Juvenile Superior Colliculus Requires Simultaneous Activation of NMDA Receptors and L-type Ca2+ Channels and Reflects Addition of Newly Functional Synapses J. Neurosci., December 6, 2006; 26(49): 12647 - 12655. [Abstract] [Full Text] [PDF]

				H. H. Yin and D. M. Lovinger Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling PNAS, May 23, 2006; 103(21): 8251 - 8256. [Abstract] [Full Text] [PDF]

				L. B. Silverman-Gavrila, P. M. R. Orth, and M. P. Charlton Phosphorylation-Dependent Low-Frequency Depression at Phasic Synapses of a Crayfish Motoneuron J. Neurosci., March 23, 2005; 25(12): 3168 - 3180. [Abstract] [Full Text] [PDF]

				J. Ronesi and D. M. Lovinger Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat J. Physiol., January 1, 2005; 562(1): 245 - 256. [Abstract] [Full Text] [PDF]

				A. W. Hendricson, J. R. Sibbald, and R. A. Morrisett Ethanol Alters the Frequency, Amplitude, and Decay Kinetics of Sr2+-Supported, Asynchronous NMDAR mEPSCs in Rat Hippocampal Slices J Neurophysiol, June 1, 2004; 91(6): 2568 - 2577. [Abstract] [Full Text] [PDF]

				J. Ronesi, G. L. Gerdeman, and D. M. Lovinger Disruption of Endocannabinoid Release and Striatal Long-Term Depression by Postsynaptic Blockade of Endocannabinoid Membrane Transport J. Neurosci., February 18, 2004; 24(7): 1673 - 1679. [Abstract] [Full Text] [PDF]

				J. G. Partridge, S. Apparsundaram, G. A. Gerhardt, J. Ronesi, and D. M. Lovinger Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression J. Neurosci., April 1, 2002; 22(7): 2541 - 2549. [Abstract] [Full Text] [PDF]

				G. Akopian and J. P. Walsh Corticostriatal Paired-Pulse Potentiation Produced by Voltage-Dependent Activation of NMDA Receptors and L-Type Ca2+ Channels J Neurophysiol, January 1, 2002; 87(1): 157 - 165. [Abstract] [Full Text] [PDF]

				K.-W. Sung, S. Choi, and D. M. Lovinger Activation of Group I mGluRs Is Necessary for Induction of Long-Term Depression at Striatal Synapses J Neurophysiol, November 1, 2001; 86(5): 2405 - 2412. [Abstract] [Full Text] [PDF]

				K.-C. Tang, M. J. Low, D. K. Grandy, and D. M. Lovinger Dopamine-dependent synaptic plasticity in striatum during in vivo development PNAS, January 10, 2001; (2001) 31374698. [Abstract] [Full Text]

				G. Gerdeman and D. M. Lovinger CB1 Cannabinoid Receptor Inhibits Synaptic Release of Glutamate in Rat Dorsolateral Striatum J Neurophysiol, January 1, 2001; 85(1): 468 - 471. [Abstract] [Full Text] [PDF]

				J. G. Partridge, K.-C. Tang, and D. M. Lovinger Regional and Postnatal Heterogeneity of Activity-Dependent Long-Term Changes in Synaptic Efficacy in the Dorsal Striatum J Neurophysiol, September 1, 2000; 84(3): 1422 - 1429. [Abstract] [Full Text] [PDF]

				M. A. Xu-Friedman and W. G. Regehr Probing Fundamental Aspects of Synaptic Transmission with Strontium J. Neurosci., June 15, 2000; 20(12): 4414 - 4422. [Abstract] [Full Text] [PDF]

				K.-C. Tang and D. M. Lovinger Role of Pertussis Toxin-Sensitive G-Proteins in Synaptic Transmission and Plasticity at Corticostriatal Synapses J Neurophysiol, January 1, 2000; 83(1): 60 - 69. [Abstract] [Full Text] [PDF]

				C. D. Hohnke and M. Sur Stable Properties of Spontaneous EPSCs and Miniature Retinal EPSCs during the Development of ON/OFF Sublamination in the Ferret Lateral Geniculate Nucleus J. Neurosci., January 1, 1999; 19(1): 236 - 247. [Abstract] [Full Text] [PDF]

				K.-C. Tang, M. J. Low, D. K. Grandy, and D. M. Lovinger Dopamine-dependent synaptic plasticity in striatum during in vivo development PNAS, January 30, 2001; 98(3): 1255 - 1260. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help